Monoclonal antibody resistant to SasA (staphylococcus aureus surface protein A) antigen and application of monoclonal antibody

A technology of monoclonal antibody and staphylococcus, applied in the fields of application, antibody, antibacterial drug, etc., can solve the problems of limited protection, unsatisfactory protection of monoclonal antibody, and no surface protein antigen can be found, and achieve highly specific binding activity Effect
CN104098693AActive Publication Date: 2014-10-15INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
Publication Date
2014-10-15

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Abstract

The invention discloses a monoclonal antibody resistant to different structural domains of a SasA (staphylococcus aureus surface protein A) antigen as well as an application of the monoclonal antibody in preparation of a drug for resisting staphylococcus aureus infection. The specific antibody has good protection performance in a mouse model when in combined utilization.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and more specifically, the invention relates to genes and gene-coded polypeptides of monoclonal antibodies against Staphylococcus aureus (Staphylococcus aureus, S.aureus) surface protein A (Staphylococcus aureus surface protein A, SasA) , and the application of said antibody in resisting Staphylococcus aureus infection. Background technique

[0002] Staphylococcus aureus is an important Gram-positive conditional pathogen. In the adult population, approximately 20% carry S. aureus continuously and another 30% carry it intermittently. In healthy individuals, S. aureus usually causes minor infections of the skin and soft tissues; however, in traumatized and immune-compromised patients, S. aureus can cause life-threatening pneumonia, bacteremia, and Severe complications including septic arthritis, osteomyelitis, etc. The exotoxin of Staphylococcus aureus can also cause food poisoning, epidermolysis an...

Claims

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