Method for preparing medical lactide

Abstract

The invention relates to the method for preparing medical lactide. The method includes: adding catalyst and high boiling-point solvent in lactic acid for condensation polymerization to enable the lactic acid to generate lactic-acid oligomer, and adding catalyst in the generated lactic-acid oligomer for depolymerization to obtain the medical lactide. The high boiling-point solvent is added during the condensation polymerization, so that a reaction system during depolymerization cannot become viscous, and is less prone to steam out, carbonize and turn yellow caused by distillation and reduction of lactide, stability of production process, product quality and variability of physical indexes are guaranteed; and the method for preparing medical lactide is high in yield, simple in reaction operation, free of danger, short in production time and beneficial to industrial production, and has quite high economic value.

Description

technical field [0001] The invention relates to the field of preparation of polymer compounds, in particular to a method for preparing medical lactide. Background technique [0002] Medical lactide is an important raw material for the synthesis of medical polylactic acid. As a new green material in the 21st century, medical polylactic acid material has broad prospects in biomedical materials. Polylactic acid is non-toxic, non-irritating, has excellent biocompatibility, bioabsorbability and biodegradability, and also has the advantages of high mechanical strength, stable chemical properties and easy processing. It can be used as a biomedical material for Drug sustained release carrier, surgical implant materials, such as: medical sutures, ophthalmic implant materials, fracture internal fixation materials, and dressing materials for large area trauma (especially burns), artificial blood vessels and tissue engineering scaffolds (such as artificial skin), etc. . [0003] In th...

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Problems solved by technology

[0015] 2. As the distillation of lactide gradually decreases, the reactant becomes viscous and carbonized, which makes it difficult to distill and the yield decreases;

[0016] 3. The lactide distilled in the early stage and the lactide distilled in the later stage are unstable in terms of physical properties, and the variability is relatively large

[0023] 1. The reactant becomes viscous and carbonized as the distillation of lactide decreases, resulting in difficulty in distillation and lower yield;

[0024] 2. There are dangers in the operation and recovery of heated high-temperature gas

[0031] 1. The color of lactide is yellow;

[0032] 2. The process is complicated, the production time is too long, and it is impossible to produce on a large scale

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