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A kind of compound florfenicol composition and its preparation process and application

The technology of compound florfenicol and florfenicol is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., which can solve the problems of ignorance of drug properties, drug poisoning of pig herds, economic loss of users, etc. To achieve the effect of quick effect, relieve the body's stress response, and improve immunity

Active Publication Date: 2015-08-19
JIUJIANG DACHENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the farmer mixes the three kinds of medicines, due to lack of understanding of the properties of the medicines and inaccurate grasp of the dosage, it is easy to have no effect due to insufficient dosage of a certain medicine, and the phenomenon of drug poisoning in pigs due to excessive dosage, resulting in economic losses for users

Method used

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  • A kind of compound florfenicol composition and its preparation process and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Weigh 10kg of florfenicol sodium succinate, 5kg of benproperine phosphate, 10kg of cimetidine hydrochloride and 75kg of anhydrous glucose, pass through 80-mesh sieve respectively, and set aside.

[0036] (2) Add 5kg of sieved benproperine phosphate and 5kg of anhydrous glucose into a small V-type mixer and mix for 5 minutes, continue to add 10kg of anhydrous glucose and mix for 5 minutes to obtain material A, take 10kg of sieved florfenicol Add 10 kg of anhydrous glucose into a small V-type mixer and mix for 5 minutes to obtain material B, take 10 kg of simetidine hydrochloride and 10 kg of anhydrous glucose and mix with a small V-type mixer for 5 minutes to obtain material C, mix A and B and C were added into a larger V-type mixer and mixed for 20 minutes to obtain mixture 1.

[0037] (3) Then add the remaining 40kg of anhydrous glucose into the above mixture 1, fully mix in a larger V-shaped mixer for 30 minutes, discharge, and pack separately to obtain the compou...

Embodiment 2

[0039] (1) Weigh 10 kg of florfenicol sodium succinate, 5 kg of benproperine phosphate, 5 kg of cimetidine hydrochloride and 80 kg of corn starch, pass through 80-mesh sieve respectively, and set aside.

[0040] (2) Take the sieved florfenicol sodium succinate and benproperine phosphate and mix them fully in a V-type mixer for 20 minutes, take the sieved cimetidine hydrochloride and add them to the above mixture and put them in the V-type mixer fully Mix for 20 minutes.

[0041] (3) Then add the sieved cornstarch to the above-mentioned mixture of florfenicol sodium succinate, benproperine phosphate and cimetidine hydrochloride, fully mix in a V-type mixer for 30 minutes, and discharge, Packed to obtain compound Florfenicol oral powder I.

Embodiment 3

[0043](1) Weigh 10 kg of florfenicol sodium succinate, 1 kg of benproperine phosphate, 5 kg of cimetidine hydrochloride and 84 kg of anhydrous glucose, pass through 80-mesh sieve respectively, and set aside.

[0044] (2) Take the sieved florfenicol sodium succinate and benproperine phosphate and mix them fully in a V-type mixer for 20 minutes, take the sieved cimetidine hydrochloride and add them to the above mixture and put them in the V-type mixer fully Mix for 20 minutes.

[0045] (3) Then add the sieved anhydrous glucose to the above-mentioned mixture of florfenicol sodium succinate, benproperine phosphate and cimetidine hydrochloride, and fully mix in a V-type mixer for 30 minutes, and discharge , Packed to obtain compound florfenicol soluble powder II.

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Abstract

The invention provides a compound florfenicol composition, which comprises the following components in part by weight: 5 to 20 parts of florfenicol or florfenicol pharmaceutically-acceptable salt in an amount which is equal to 5 to 20 parts of florfenicol, 1 to 5 parts of phosphoric acid benproperine and 5 to 10 parts of hydrochloric acid cimetidine. The florfenicol pharmaceutically-acceptable salt is selected from florfenicol sodium succinate and florfenicol sodium phosphate, preferably the florfenicol sodium succinate. The invention also provides application of the compound florfenicol composition to the preparation of a medicine for treating respiratory disease syndromes of pigs. The florfenicol sodium succinate, phosphoric acid benproperine and hydrochloric acid cimetidine are compositely used and are reasonable in proportion; the composition has double efficacy, clinical symptoms caused by respiratory syndromes of pigs can be alleviated quickly, damage of the respiratory diseases to organisms can be reduced, pain of the diseased pigs can be relieved, stress responses of diseased livestock bodies are reduced, and the composition can promote the recovery of organisms and improve immunities.

Description

technical field [0001] The invention belongs to the field of animal health care and veterinary medicine, in particular to a veterinary compound florfenicol composition and its preparation process and application. Background technique [0002] Refractory Porcine Respiratory Disease Syndrome (PRDC), which has occurred repeatedly and widely in pig farms in recent years, has caused huge losses to the pig industry. Respiratory disease syndrome is a mixed infection caused by a variety of pathogens (including PRRS, circovirus, Haemophilus parasuis, mycoplasma pneumonia, infectious pleuropneumonia, panting disease, etc.) and harsh production environment. The main manifestations are cough, dyspnea, wheezing, confluent bronchitis, gastric ulcer and other clinical symptoms. Haemophilus parasuis and porcine infectious pleuropneumonia can cause pig death, and mycoplasma pneumonia can seriously affect the growth of pigs and bring great losses to the pig industry. [0003] Florfenicol i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4453A61P11/06A61P31/04A61P1/04A61P11/14A61K31/165A61K31/4164
Inventor 虞枫张文武温福华程玉祥
Owner JIUJIANG DACHENG PHARMA CO LTD
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