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Microencapsulated amino-acid composition and preparation method of microencapsulated amino-acid composition

A technology of amino acid and composition, applied in the field of microencapsulated amino acid composition, which can solve unsolved problems such as amino acid dispersibility, rapid dissolution, lack of dispersion and instant solubility in water, and no evaluation of product stability, etc., to achieve convenient and quick use and taking, dispersion and instant dissolution, and the effect of transparent solution

Active Publication Date: 2013-02-06
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A Chinese patent application (publication number CN101744110A) provides a method for amino acid microencapsulation, which uses stearic acid and other high-freezing point fatty acid esters as coating materials, and is prepared by melting the wall material and mixing with active amino acids and coating. Microcapsules, the product only solves the problem of amino acid embedding, but it does not have the ability to disperse and dissolve in water, the bioabsorption is low, and the product application is limited
[0005] Chinese patent application (publication number CN101658244) discloses a microencapsulated amino acid with fat-soluble capsule material. Dissolved market demands
However, its products still direct the preparation of active ingredients into capsules and tablets. Compared with instant granules, it is still difficult for people in need to take them, especially those with dysphagia, and the bioavailability is low.
There is no evaluation of product stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0038] Mix 98kg of three kinds of amino acids (according to the mass ratio, leucine:isoleucine:valine=3:1:1), add the excipient 2 in Table 1 and 100.5kg of purified water, and granulate by extrusion Granules were machined and dried in a dryer. The obtained dried granules were passed through a 35-mesh sieve, and the bulk density of the granules was 0.62 g / ml. Put 2g of the product into 100ml of 25°C water, self-disperse in 14s, completely dissolve in 5min20s, and the solution turbidity is 23NTU. The solution is transparent, no precipitation, no floating, no foam.

Embodiment 3

[0040] Mix 98kg of three amino acids (according to mass ratio, leucine:isoleucine:valine=3:1:2), and add excipient 3 in Table 1 and 15kg of purified water. Stir in a stirring tank, after stirring evenly, shear for 20 minutes, homogenize, spray dry, and pass through a 35-mesh sieve. Dry granules were obtained, the bulk density of which was 0.35 g / ml. Put 2g of the product into 100ml of 25°C water, self-disperse in 15s, dissolve completely in 6min10s, and the turbidity of the solution is 17NTU. The solution is transparent, no precipitation, no floating, a small amount of foam.

Embodiment 4

[0042] 98kg of leucine was added to it with auxiliary material 4 in Table 1 and 100kg of purified water, and the mixture was stirred in a stirring tank. After stirring evenly, it was sheared for 20 minutes, homogenized, and spray-dried. Pass through a 35-mesh sieve to obtain dry granules with a bulk density of 0.35 g / ml. Put 1.5g of the product into 100ml of 25°C water, self-disperse in 8s, completely dissolve in 4min50s, and the solution turbidity is 21NTU. The solution is transparent, no precipitation, no floating, a small amount of foam.

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Abstract

The invention provides a microencapsulated amino-acid composition and a preparation method of the microencapsulated amino-acid composition. The microencapsulated amino-acid composition can be dispersed quickly and dissolved clearly. The preparation method of the microencapsulated amino acid composition comprises the steps that auxiliary materials such as a coating agent and a wetting agent are added to an amino-acid mixture, and the wetting speed of composition particles to water is increased greatly by surface modification of microencapsulated crumby particles. A mass ratio of the amino acid to the auxiliary materials in the composition is 100 / 0.1-10.0. Compared with the conventional product, the composition has better dispersing and fast dissolving properties in the water, and a solution is transparent and free of sediment, floatage and foam. The shelf life of the composition is stable, the composition can be used more conveniently and rapidly, facilitates fast absorption of human bodies, and solves the problems that edible demands of humans cannot be met, the amino-acid is difficult to take and absorb, and taste and odor of the amino-acid get worse as branched-chain amino acid in the amino-acid is low in dissolvability and poor in hydrophilicity and stability. The preparation method is simple in technology, and facilitates the industrial production.

Description

technical field [0001] The present invention relates to an instant, stable microencapsulated amino acid composition capable of dissolving and clarifying rapidly and a preparation method thereof, to solve the problem of low solubility and poor hydrophilicity of branched-chain amino acids among amino acids; and poor stability, especially discoloration within the effective period , Bad taste and other problems. Background technique [0002] Amino Acid: A general term for a class of organic compounds containing amino and carboxyl groups. The basic unit of biological functional macromolecular protein is the basic substance that constitutes the protein required for animal nutrition, and is an important nutrient element for the human body to maintain normal physiological activities. For example: branched-chain amino acids, including L-leucine, L-isoleucine, and L-valine, are all essential amino acids for the human body. Their combination is referred to as BCAA (Branch Chain Amino ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/198A61P3/02
CPCA61K9/1652A61K9/2866A61K31/4172A61K31/405A61K9/1617A61K9/1605A61K9/2059A23L1/22075C08J3/12A23L1/0029A23V2002/00A61K31/198A61K38/00A61K9/0095B01J13/22A23L1/0047A61K9/1682A61K31/401A23L1/0076A61K31/195A23L1/3051A23L1/3008A23P10/30A23P30/20A23L33/175A61P3/02A23V2200/224A23V2250/0626A23V2250/0628A23V2250/0654A23V2250/51082A23V2250/51086A23V2250/5028A61K2300/00
Inventor 吴文忠陈剑彬张月梅
Owner INNOBIO CORP LTD
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