Compound promoting activity of estrogen related receptor alpha (ERR alpha), and its use

A compound and estrogen technology, applied in the field of compounds, can solve the problems affecting the quality of life of women in old age, and achieve the effect of slowing down the phenomenon of osteoporosis

Inactive Publication Date: 2013-02-13
I-SHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The study also found that after menopause, the phenomenon of osteoporosis caused by the obvious decline of estrogen in the body seriously affects the quality of life of women in their later years

Method used

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  • Compound promoting activity of estrogen related receptor alpha (ERR alpha), and its use
  • Compound promoting activity of estrogen related receptor alpha (ERR alpha), and its use
  • Compound promoting activity of estrogen related receptor alpha (ERR alpha), and its use

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Embodiment Construction

[0031] In order to make the above-mentioned and other purposes, features and advantages of the present invention more obvious and understandable, the preferred embodiments of the present invention are specifically cited below, and in conjunction with the accompanying drawings, the detailed description is as follows:

[0032] The problem of osteoporosis is closely related to estrogen related receptors (ERRs). Therefore, compounds that can regulate estrogen related receptors (ERRs) also mean that they can improve severe fractures caused by osteoporosis (eg hip fractures, vertebral fractures).

[0033] The present invention discloses a compound that promotes the activity of estrogen related receptor alpha (ERRα), which is represented by the following formula (x):

[0034]

[0035] Wherein, ring A is a benzene ring or a cyclohexyl ring, and ring B is a furan ring or a dihydrofuran ring, and the dotted line (---) represents the presence or absence of a double bond. A preferred ...

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Abstract

The invention relates to a compound and its use, and especially relates to a compound promoting the activity of ERR alpha, and its use in the preparation of medicines treating the osteoporosis. The compound can improve the menopausal osteoporosis phenomena.

Description

technical field [0001] The present invention relates to a compound and its use, especially a compound for promoting estrogen-related receptor α activity and its use. Background technique [0002] Female hormones include estrogen and progesterone. They can make women have a beautiful figure, youthful appearance, good reproductive ability, and provide great help to maintain women's bone density, cardiovascular function and brain memory. [0003] The study also found that after menopause, the phenomenon of osteoporosis caused by the obvious decline of estrogen in the body seriously affects the quality of life of women in their later years. Women's bone density is not as high as that of men from birth, and the rate of bone loss after menopause is faster than that of men, which is why many women often have osteoporosis after menopause. [0004] Postmenopausal osteoporosis belongs to the first type of osteoporosis, and its pathogenesis is mainly due to the massive loss of bone m...

Claims

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Application Information

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IPC IPC(8): C07J73/00A61K31/58A61P19/10
Inventor 黄建富陈建宇吴其昀
Owner I-SHOU UNIVERSITY
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