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Preparation method of target compound nano particle

A composite nanoparticle and nanoparticle technology, which can be used in medical preparations with non-active ingredients, wave energy or particle radiation treatment materials, medical preparations containing active ingredients, etc., can solve the problem of poor stability of anti-tumor drug carriers and drug loading Small amount and other problems, to achieve the effect of high feasibility, small side effects, and increase drug concentration

Inactive Publication Date: 2013-11-27
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the technical problems of poor stability and small drug loading capacity of current anti-tumor drug carriers, the present invention provides a preparation method of targeted composite nanoparticles

Method used

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  • Preparation method of target compound nano particle
  • Preparation method of target compound nano particle
  • Preparation method of target compound nano particle

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specific Embodiment approach 1

[0040] Specific embodiment 1: The preparation method of the targeted composite nanoparticles in this embodiment is carried out according to the following steps:

[0041] 1. Preparation of magnetic nanoparticles:

[0042] 10 mL of FeCl with a concentration of 1 mol / L 3 Aqueous solution, 2.5mL FeSO 4 ·7H 2 The HCl solution of O was added to 125 mL of NH with a concentration of 0.7 mol / L 3 ·7H 2 0, continue to stir for 30min, centrifuge and collect the product in the supernatant, the product in the supernatant is washed 3 times with deionized water, then be dispersed in 150mL deionized water again, obtain Fe 3 o 4 Nanoparticle solution;

[0043] The FeSO 4 ·7H 2 O in HCl solution FeSO 4 ·7H 2 The concentration of O is 2mol / L, and the concentration of HCl is 2mol / L;

[0044] 2. Preparation of Fe 3 o 4 -HCPT nanoparticles:

[0045] 10mLFe 3 o 4 Disperse the nanoparticle solution into 10ml of polyhydrochloroallylamine NaCl aqueous solution, ultrasonically react for 3...

specific Embodiment approach 2

[0066] Embodiment 2: This embodiment differs from Embodiment 1 in that in step 12, 0.03 g of 1,2-dimercapto-3-cyclohexyl polyethylene glycol and 3.5 ml of tetrahydrofuran are added to the centrifuge tube. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0067] Specific embodiment three: the difference between this embodiment and specific embodiment one is that in step thirteen, 60mg~90mgFe 3 o 4 -HCPTSiO 2 A methanol solution of integrated nanoparticles coupled with a porphyrin-based photosensitizer, 10 mL of N,N-dimethylformamide, and 50 mg of targeted biomolecules or antitumor drugs were stirred and reacted at room temperature for 2 hours. Others are the same as in the first embodiment.

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Abstract

The invention provides a preparation method of a target compound nano particle, relating to a preparation method of target treatment integration compound nano particles. The invention solves the technical problems of poor carrier stability and small drug-loading quantity of the traditional antineoplastic drugs. The method comprises the following steps of: preparing a methanol solution of an integrated nano particle of a Fe3O4-HCPT@SiO2 coupling porphyrin photosensitizer; and stirring the methanol solution of the integrated nano particle of the Fe3O4-HCPT@SiO2 coupling porphyrin photosensitizer, N,N-dimethylformamide and target biomolecule or antitumor drug for reacting at the room temperature, and centrifuging to obtain the target compound nano particle. Polystyrolsulfon acid (PSS) and 10-hydroxycamptothecine are absorbed on a Fe3O4 magnetic nano particle through a self-assembly mode. The preparation method is high feasibility; the target compound nano particle has a physical target function of the magnetic nano particle and an active target function of further functionally modifying the biomolecule on the surface; and the medicine concentration can be increased under a dual-target function.

Description

technical field [0001] The invention relates to a preparation method of targeted diagnosis and treatment integrated composite nanoparticles. Background technique [0002] According to the World Health Organization officials pointed out: by 2010, malignant tumors will replace cardiovascular disease as the disease with the largest number of deaths in the world. At present, it can be used clinically to diagnose tumors: optical imaging, positron emission tomography, magnetic resonance imaging, ultrasound and computerized tomography imaging; to treat tumors: three main methods: surgery, radiotherapy and drug therapy, photodynamic therapy, Auxiliary methods such as hyperthermia, the above various therapies have all received good results in diagnosis and treatment. For example, porphyrin compounds are used for optical imaging, and the strong absorption wavelength of the porphyrin ring in its structure is 405nm after light absorption, which is excited to generate fluorescence in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/32A61K47/04A61K31/4745A61K41/00A61K31/337A61K31/704A61K31/513A61K31/519A61K39/395A61P35/00
Inventor 郭喜明郭斌薄璇
Owner HARBIN INST OF TECH
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