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Drug composition

A technology of composition and medicine, applied in the field of medicine

Active Publication Date: 2014-09-10
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]The LD50 of curcumedione is significantly lower than that of curcumol, and curcumol is easy to sublimate, so the quality of preparations containing curcumol is unstable, which affects its curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0157] Prescription: gemmazone 8g, furandadiene 38.4g, curcumadione 18g, β-elemene 4g, curcumol 0.1g, curcumene 0.1g, and borneol 75g.

[0158] Dosage form: suppository.

[0159] Preparation method: Mix the prescription amount of gemmazone, furandiene, curcumene, β-elemene, curcumol, curcumene and 70g polysorbate 80, and dissolve 75g borneol with proper amount of ethanol, and mix with the above solution Mix well.

[0160] The prescription amount of polyoxyethylene stearate is 1510g, heated on a water bath to melt, add the above-mentioned medicinal solution, stir evenly, and fill to make 1000 suppositories, each 1.74g.

Embodiment 2～8

[0162] The suppository was prepared according to the following prescription, and the preparation method was the same as in Example 1.

[0163] Example 2 3 4 5 6 7 8 Gemmazone 5.5 6 9 10 11 13 14 Furandadiene 37 33 30 28 25 15 11 Curcumone 6 8 9 15 18 20 23 β-elemene 10.5 10 9.5 8 6.5 5 4.5 Curcumol 0 0.05 0.15 0.1 0.4 0.35 0.5 Curcumene 0.05 0 0.02 0.03 0.04 0.05 0.045 Borneol 30 40 50 60 70 80 90 Polysorbate 80 52 57 64 68 73 80 84 Polyoxyethylene stearate 1561 1572 1465 1571 1582 1541 1547

Embodiment 9

[0165] Prescription: gemmazone 6.5g, furandiene 32g, curedione 21g, β-elemene 8.5g, curcumol 0.45g, borneol 35g.

[0166] Dosage form: effervescent tablet.

[0167] Preparation:

[0168] 1) Take β-cyclodextrin, add an appropriate amount of water according to 25ml / g, stir to make it completely dissolved, and heat if necessary to obtain β-cyclodextrin solution; gemmazone, furandadiene, turmeric, β-elemi Ene, curcumol, borneol 35g, diluted with absolute ethanol and slowly added to β-cyclodextrin solution, continue to stir until homogeneous, put in the refrigerator overnight, suction filtered, washed with a small amount of petroleum ether 3 times, frozen, Get a white powder.

[0169] 2) Mix the above white powder with 35g of borneol, 150g of citric acid and 160g of lactose; separately take 120g of sodium bicarbonate and 160g of lactose and mix them with 5% PVP anhydrous ethanol solution as a binder for granulation, 50℃ Dry, granulate, add appropriate amount of PEG6000, mix well, and co...

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Abstract

The present invention belongs to the technical field of medicine, and the present invention provides a pharmaceutical composition, which contains gemmacone, furandiene, curdione, β-elemene, curcumol, curcumene, and borneol. things. The pharmaceutical composition has clear ingredients and controllable quality; the pharmaceutical composition controls the weight of curcumene and curcumol to reduce the irritation of the drug; the pharmaceutical composition of the present invention can be used to prepare suppositories, ointments, capsules, Effervescent tablet, gel, lotion, film or foam; the pharmaceutical composition of the present invention has a good therapeutic effect on HR-HPV and / or LR-HPV and cervical diseases, and is suitable for a wide range of clinical application.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene and borneol. Background technique [0002] The zedoary oil extracted from the traditional Chinese medicine zedoary is the first clinically used drug for the treatment of cervical cancer in my country, and it has been recorded in the Chinese Pharmacopoeia. The main chemical component of zedoary oil is sesquiterpenes; clinical practice has proved that the total effective rate of treating cervical cancer is 64.4%; it has a destructive effect on cancer tissue and has no obvious effect on normal tissue. Zedoary oil not only has a direct inhibitory effect on mouse Ehrlich's ascites cancer cells in vitro; moreover, the Ehrlich's ascites cancer cells that have been exerted by Curcuma can successfully make mice obtain obvious active immunity. Preliminary observations of p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/35A61K31/343A61K31/122A61K31/045A61K31/015A61P31/20A61P15/02A61P15/00A61P35/00
Inventor 陈容徐扬冯仲异史朝辉
Owner HAINAN BIKAI PHARM CO LTD
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