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A technology of composition and medicine, applied in the field of medicine
Active Publication Date: 2014-09-10
HAINAN BIKAI PHARM CO LTD
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[0006]The LD50 of curcumedione is significantly lower than that of curcumol, and curcumol is easy to sublimate, so the quality of preparations containing curcumol is unstable, which affects its curative effect
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[0159] Preparation method: Mix the prescription amount of gemmazone, furandiene, curcumene, β-elemene, curcumol, curcumene and 70g polysorbate 80, and dissolve 75g borneol with proper amount of ethanol, and mix with the above solution Mix well.
[0160] The prescription amount of polyoxyethylene stearate is 1510g, heated on a water bath to melt, add the above-mentioned medicinal solution, stir evenly, and fill to make 1000 suppositories, each 1.74g.
Embodiment 2～8
[0162] The suppository was prepared according to the following prescription, and the preparation method was the same as in Example 1.
[0168] 1) Take β-cyclodextrin, add an appropriate amount of water according to 25ml / g, stir to make it completely dissolved, and heat if necessary to obtain β-cyclodextrin solution; gemmazone, furandadiene, turmeric, β-elemi Ene, curcumol, borneol 35g, diluted with absolute ethanol and slowly added to β-cyclodextrin solution, continue to stir until homogeneous, put in the refrigerator overnight, suction filtered, washed with a small amount of petroleumether 3 times, frozen, Get a white powder.
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Abstract
The present invention belongs to the technical field of medicine, and the present invention provides a pharmaceutical composition, which contains gemmacone, furandiene, curdione, β-elemene, curcumol, curcumene, and borneol. things. The pharmaceutical composition has clear ingredients and controllable quality; the pharmaceutical composition controls the weight of curcumene and curcumol to reduce the irritation of the drug; the pharmaceutical composition of the present invention can be used to prepare suppositories, ointments, capsules, Effervescent tablet, gel, lotion, film or foam; the pharmaceutical composition of the present invention has a good therapeutic effect on HR-HPV and / or LR-HPV and cervical diseases, and is suitable for a wide range of clinical application.
Description
technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing gemmacone, furadienes, curdione, β-elemene, curcumol, curcumene and borneol. Background technique [0002] The zedoary oil extracted from the traditional Chinese medicine zedoary is the first clinically used drug for the treatment of cervical cancer in my country, and it has been recorded in the Chinese Pharmacopoeia. The main chemical component of zedoary oil is sesquiterpenes; clinical practice has proved that the total effective rate of treating cervical cancer is 64.4%; it has a destructive effect on cancer tissue and has no obvious effect on normal tissue. Zedoary oil not only has a direct inhibitory effect on mouse Ehrlich's ascitescancer cells in vitro; moreover, the Ehrlich's ascitescancer cells that have been exerted by Curcuma can successfully make mice obtain obvious active immunity. Preliminary observations of p...
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