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Preparation method and application of antihypertension tablet

An antihypertensive tablet and extraction technology, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, and medical raw materials derived from leeches/helminths, etc. The effect of reducing dosage

Inactive Publication Date: 2013-03-27
陶利
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Jiangya Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

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  • Preparation method and application of antihypertension tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 200g of Scutellaria baicalensis, 150g of cassia seed, 150g of hawthorn, 300g of mistletoe, 150g of sycamore leaves, 100g of Morus alba bark, and 100g of earthworm. The volume percentage of the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug·min, and the extraction time is 150min, to obtain a supercritical extract for use; take the rest of the traditional Chinese medicine, grind it, and add 2L of 70 % ethanol, put into a microwave extraction device for microwave extraction, extraction power 400W, extraction 2 times, 4 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times Measure the volume of the column eluate, recover ethanol under reduced pressure, concentrate and dry to obtain the microwave extract, and set aside; mix the above supercritical extract and microwave extract, add starch, 70% ethano...

Embodiment 2

[0028] Take 200g of Scutellaria baicalensis, 150g of cassia seeds, 150g of hawthorn, 300g of mistletoe, 150g of sycamore leaves, 100g of mulberry bark, and 100g of earthworm, and add scutellaria baicalensis and earthworm to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure...

Embodiment 3

[0031] Take 200g of Scutellaria baicalensis, 150g of cassia seeds, 150g of hawthorn, 300g of mistletoe, 150g of stinky phoenix leaves, 100g of mulberry bark, and 100g of earthworm, and add scutellaria baicalensis and earthworm to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under...

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Abstract

The invention provides a preparation method of antihypertension tablet which is prepared from crude drugs including 200g of Radix Scutellariae, 150g of semen cassiae, 150g of hawthorn, 300g of mistletoe, 150g of harlequin glorybower leaf, 100g of White Mulberry Root-bark and 100g of lumbricus through supercritical extraction and microwave extraction, so that the content of baicalein is greatly improved. The invention also provides the application of the antihypertension tablet in preparing medicines for restraining proliferation of human giant lung carcinoma cell, 801-D cell.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of an antihypertensive tablet. Background technique [0002] Jiangya tablets are recorded in the standard WS3-B-0760-91 of the Ministry of Health, and are made from 200g of Scutellaria baicalensis, 150g of cassia seeds, 150g of hawthorn, 300g of mistletoe, 150g of sycamore leaves, 100g of mulberry bark, and 100g of earthworm. Buck. For high blood pressure. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Jiangya Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , Seriously affecting the clinical application of this product. Contents of the invention [0004] Purpose of the invent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/855A61K9/20A61P35/00A61K35/64A61K35/62
Inventor 不公告发明人
Owner 陶利
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