Preparation method of CT imaging molecular probe of folate receptor targeted tumor

A technology of folic acid and gold ions, used in the preparation of X-ray contrast agents, can solve the problems of uneven particle size and no verification, and achieve the effects of strong absorption, system uniformity and high attenuation ability
CN102989015AInactive Publication Date: 2013-03-27XI AN JIAOTONG UNIV
2 Cites 3 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2013-03-27
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a preparation method of a CT imaging molecular probe of folate receptor targeted tumors, which comprises the following steps: dissolving folic acid which is used as a wrapping agent in a solution which contains gold ions and is used for preparing nanogold, adjusting the pH to 7.0-7.5 to obtain a mixed solution, wherein the molar ratio of folic acid to gold ions is 1:2-6; adding a reducing agent into the mixed solution, rapidly stirring and reacting for at least 1 hour, naturally cooling after the reaction, performing dialysis to remove unreacted parts so as to obtain the nanogold coated by folic acid. The nanogold coated by folic acid FA-GNP prepared in the invention has high attenuation capability for X ray, and can be used as a CT imaging contrast agent; the FA-GNP can provide CT images with high contrast for tumors.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of CT molecular imaging, and relates to a preparation method of a folic acid receptor targeting tumor CT imaging molecular probe. Background technique

[0002] Malignant tumor is a common disease that seriously endangers human health, and has become one of the main causes of human death. In recent years, with the development of economy and technology, people's living environment and living habits are changing day by day. Tumor has become a problem that endangers human health worldwide and its incidence is on the rise. Compared with developed countries, the mortality rate of malignant tumors in my country is higher than the world average. The time of diagnosis determines the chance of a patient being cured. According to a large number of clinical data statistics, the five-year survival rate of malignant tumors detected in the early stage can reach more than 90%, while that in the late stage is only about 20%...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More