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Application of aphanamixoid A in preparing medicament for treating hemorrhagic fever with renal syndrome

A technology for renal syndrome and hemorrhagic fever, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as uncertain effects, and achieve strong inhibitory activity of hemorrhagic fever with renal syndrome virus and highlight the essence The effect of sexuality

Inactive Publication Date: 2013-04-03
何晓涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiviral treatments such as ribavirin and interferon are often used clinically, but the effect is not yet certain

Method used

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  • Application of aphanamixoid A in preparing medicament for treating hemorrhagic fever with renal syndrome
  • Application of aphanamixoid A in preparing medicament for treating hemorrhagic fever with renal syndrome
  • Application of aphanamixoid A in preparing medicament for treating hemorrhagic fever with renal syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Aphanamixoid A tablet involved in the present invention:

[0013] Take 20 grams of compound Aphanamixoid A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Aphanamixoid A capsules involved in the present invention:

[0015] Get 20 grams of compound Aphanamixoid A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] In order to better understand the essence of the present invention, the following experimental research results of Aphanamixoid A will illustrate its application in the field of pharmacy.

[0018] The specific experiment is as follows:

[0019] 1. Experimental study of Aphanamixoid A against hemorrhagic fever with renal syndrome virus

[0020] (1) In vitro inhibition experiment of hemorrhagic fever with renal syndrome virus

[0021] 1 material

[0022] (1) Virus strain: the international standard strain of hemorrhagic fever with renal syndrome virus 76-118, which is preserved...

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Abstract

The invention discloses an application of aphanamixoid A in preparing a medicament for treating hemorrhagic fever with renal syndrome. Researches of aphanamixoid A in virus in-vitro and in-vivo inhibition experiments of hemorrhagic fever with renal syndrome indicate that the aphanamixoid A has low toxicity to cells, can directly kill virus of hemorrhagic fever with renal syndrome, can remarkably inhibit multiplication of the virus, and can remarkably protect susliks infected by the virus, so that the attack time is postponed, the disease course is prolonged, and the death rate is reduced. Therefore, the aphanamixoid A is an effective and safe medicament for treating hemorrhagic fever with renal syndrome.

Description

technical field [0001] The present invention relates to the application of Aphanamixoid A, in particular to the application of Aphanamixoid A in the pharmaceutical field. Background technique [0002] There are 13 kinds of human viral hemorrhagic fever in the world. According to whether the disease has kidney damage, it is divided into two categories: with kidney damage and without kidney damage. In my country, it is mainly hemorrhagic fever with renal syndrome (HFRS), also known as epidemic hemorrhagic fever. Hemorrhagic fever (EHF); called Korean hemorrhagic fever (KHF) in North Korea; called hemorrhagic nephritis nephritis (HNN) in the Soviet Union; due to the establishment of specific serological diagnosis and the resolution of etiology, in 1982, the World Health Organization named it as renal syndrome Symptoms of hemorrhagic fever. [0003] The disease is caused by Korean hemorrhagic fever virus (or Hantaan virus), a natural foci disease with rodents as the main source o...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P31/14A61P13/12
Inventor 何晓涛
Owner 何晓涛
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