Full-automatic determining instrument of red blood cell osmotic fragility

Abstract

The invention discloses a full-automatic determining instrument of red blood cell osmotic fragility. The full-automatic determining instrument is based on the principle of light-proof turbidimetry and consists of a sample absorbing device, an automatic electromechanical device, a light detector and a circuit system, wherein the sample absorbing device is used for absorbing a blood sample through the instrument; the automatic electromechanical device is used for accomplishing various control actions in the automatic measurement of the instrument; the light detector is used for radiating reaction liquid to generate a permeable light signal; the circuit system is used for controlling various stepper motors, electromagnetic valves and peristaltic pumps, converting the light signal into an electric signal, amplifying the electric signal and converting the electric signal into a digital signal so as to carry out data processing analysis, data display and communication between the instrument and a PC (Personal Computer). The full-automatic determining instrument is convenient to operate, rapid in measuring speed, high in precision and good in repeatability, and the information of the red blood cell osmotic fragility of the blood sample can be obtained through full-automatic detection.

Description

technical field [0001] The invention relates to an automatic measuring instrument for osmotic fragility of red blood cells, which can be used for clinical screening of microcytic anemia such as thalassemia. Background technique [0002] Human red blood cells account for about 40% of the total volume of whole blood, mainly composed of 64% water and 32% hemoglobin. When red blood cells are in hypotonic saline solution, when water penetrates to a certain extent, the red blood cells swell and rupture, and the hemoglobin in the cells overflows, which is called hypotonic hemolysis. The resistance of the red blood cell membrane to the hemolysis of hypotonic saline solution is called red blood cell osmotic fragility. In patients with thalassemia and iron deficiency anemia, the production of hemoglobin in red blood cells is reduced, the cell volume is smaller, and the osmotic fragility is significantly lower than that of normal people. anemia. [0003] At present, there are two m...

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Problems solved by technology

[0006]The above two methods require manual operation, and the operation is cumbersome and time-consuming, so it is not suitable for clinical mass detection

The conventional method needs to judge the results by naked eyes, which is easily affected by human subjective factors, resulting in poor accuracy of the results; a tube of quantitative screening test must be centrifuged due to the presence of undissolved red blood cells, free hemoglobin and other components in the blood in the reaction solution. In order to carry out accurate colorimetric determination of the results, it is impossible to achieve dynamic determination and fully automated analysis of the reaction process

Therefore, there is no instrument for automatic determination of red blood cell osmotic fragility

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