Baofukang suppository with expansion carrier

An expansion carrier, Baofukang suppository technology, applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, suppository delivery, etc., can solve the problems of slow onset time, slow melting, stimulating effect, etc. To achieve the effects of fast onset time, symptom relief and long acting time

Active Publication Date: 2013-04-17
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patents CN200410060826.3 and CN1840129 1 A disclose a gel containing curcuma oil and borneol respectively; Chinese patent CN1650961A discloses Baofukang vaginal film; Chinese patent CN 16509601A discloses Baofukang vaginal effervescent tablets; Chinese patent CN 1927370 discloses a kind of Baofukang vagina soft capsule; Chinese patent CN1843489 discloses a kind of Baofukang vaginal capsule, but the above-mentioned improvement is still unsatisfactory
But still there are following deficiencies for Baofukang suppository: 1, the bioavailability of active drug is low; 2, easily pollute clothing; 3, use inconvenient; It is easy to become soft; 6. It dissolves slowly in the vagina; 7. Although the active ingredient is volatile, it still cannot be evenly distributed throughout the vaginal wall and cervix, and penetrates into the deep folds of the mucosa; 8. Polyethylene glycol is harmful to the body. Skin and mucous membranes are irritating and easy to absorb moisture

Method used

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  • Baofukang suppository with expansion carrier
  • Baofukang suppository with expansion carrier
  • Baofukang suppository with expansion carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Ingredients Curcuma Oil 82g Borneol 75g Tween 80 75g Glycerin Gelatin 3400g Expanded Sliver 1000g

[0089] Preparation method Mix 81g of zedoary oil and 8075g of Tween, dissolve 75g of borneol with appropriate amount of ethanol, and mix with the above oil solution evenly. Take half of the mixed solution and put it in a plastic shaped stopper bottle, put it into an expanded cotton strip, fully infiltrate it, let it cool, then add the other half of the mixed solution, take it out after cooling, and make 1000 capsules.

[0090] combine figure 1 In the Baofukang suppository 1 shown in Example 1 with an expanded sliver, the drug-containing layer 1 half-surrounds the expansion carrier 2 , and the axial direction of the expanded sliver is longer than the radial direction. After testing, the expansion value of the expansion carrier is 2. combine figure 2 As shown, the used sliver tail has a backguy 4, and the surface is provided with a keel 5.

Embodiment 2

[0092] Prescription Curcuma Oil 82g, Borneol 75g, Tween 80 75g, Polyoxyethylene Stearate 1551g, Expanded Sliver 1200g

[0093] Preparation method Mix 75g of turmeric oil with Tween 80, dissolve borneol with an appropriate amount of ethanol, and mix with the above oil solution evenly. Take another 1551g of polyoxyethylene stearate, melt it on a water bath, add the above liquid medicine, stir well, pour it into a suppository mold, put it into an expanded tampon, take it out after cooling, and make 1000 capsules.

Embodiment 3

[0095] Prescription Curcuma oil 82g, borneol 75g, polyoxyl (40) stearate 1235g, lauryl nitrogen Ketone 17.5g Macrogol 4000 200g Macrogol 200 120g Expanded tampons 800g

[0096] Preparation method Add zedoary oil and borneol to an appropriate amount of ethanol, stir to dissolve. Take another polyoxyl (40) stearate 1235g and polyethylene glycol 4000 200g, heat to melt, add polyethylene glycol 200 120g and lauryl nitrogen Ketone 17.5g, stir well, add above-mentioned liquid medicine, stir well, pour into suppository mold, put into expansion tampon, take out after cooling, make 1000 capsules, to get final product.

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Abstract

The invention relates to a Baofukang suppository with an expansion carrier, which is a vaginal suppository prepared by the following components in parts by weight: 60-100 parts of zedoary oil, 60-100 parts of borneol and matrix and 500-2,000 parts of expansion carrier; the surface of the expansion carrier is coated with a drug containing layer formed by at least a part of active ingredients and at least a part of matrix, and the expansion value of the expansion carrier is greater than 1.5. The Baofukang suppository has the benefits that the Baofukang suppository is convenient to use and long in effect time and takes effect fast; the pollution to clothes is avoided; an active drug can be uniformly distributed on a whole vaginal wall and uterine cervix, and permeated into a deep site of mucosa ruffles; surprisingly, the technological effects can still be realized under the conditions that even polyethylene glycol is not used and water is almost not used; the effective rate to mycotic vaginitis is 96.2%; and the effective rate to senile vaginitis is 96.6%.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine suppositories, in particular to a Baofukang suppository containing an expansion carrier. Background technique [0002] The traditional Chinese medicine composition prepared from zedoary oil and borneol may have a variety of medical uses, such as Hainan Bikai Pharmaceutical Co., Ltd. published a series of patents on the use of zedoary oil and borneol formulations, CN102049009 is the application of drugs for the treatment of infertility; CN102058850A It is the purpose of treating constipation; CN102091298A is the purpose of treating hemorrhoids; CN101422585 is the purpose of treating HPV infection, cervical squamous intraepithelial neoplasia, papilloma and cervical cancer; application. However, the medical use of the above-mentioned traditional Chinese medicine composition approved by the State Food and Drug Administration is only for leukorrhea, fungal vaginitis, senile vaginitis, and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/02A61K47/42A61K47/34A61P15/02A61P15/00A61K31/045A61K47/10A61K47/14A61K47/26
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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