Baofukang suppository with expansion carrier

Abstract

The invention relates to a Baofukang suppository with an expansion carrier, which is a vaginal suppository prepared by the following components in parts by weight: 60-100 parts of zedoary oil, 60-100 parts of borneol and matrix and 500-2,000 parts of expansion carrier; the surface of the expansion carrier is coated with a drug containing layer formed by at least a part of active ingredients and at least a part of matrix, and the expansion value of the expansion carrier is greater than 1.5. The Baofukang suppository has the benefits that the Baofukang suppository is convenient to use and long in effect time and takes effect fast; the pollution to clothes is avoided; an active drug can be uniformly distributed on a whole vaginal wall and uterine cervix, and permeated into a deep site of mucosa ruffles; surprisingly, the technological effects can still be realized under the conditions that even polyethylene glycol is not used and water is almost not used; the effective rate to mycotic vaginitis is 96.2%; and the effective rate to senile vaginitis is 96.6%.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine suppositories, in particular to a Baofukang suppository containing an expansion carrier. Background technique [0002] The traditional Chinese medicine composition prepared from zedoary oil and borneol may have a variety of medical uses, such as Hainan Bikai Pharmaceutical Co., Ltd. published a series of patents on the use of zedoary oil and borneol formulations, CN102049009 is the application of drugs for the treatment of infertility; CN102058850A It is the purpose of treating constipation; CN102091298A is the purpose of treating hemorrhoids; CN101422585 is the purpose of treating HPV infection, cervical squamous intraepithelial neoplasia, papilloma and cervical cancer; application. However, the medical use of the above-mentioned traditional Chinese medicine composition approved by the State Food and Drug Administration is only for leukorrhea, fungal vaginitis, senile vaginitis, and c...

AI Technical Summary

Problems solved by technology

[0004] Chinese patents CN200410060826.3 and CN1840129 1 A disclose a gel containing curcuma oil and borneol respectively; Chinese patent CN1650961A discloses Baofukang vaginal film; Chinese patent CN 16509601A discloses Baofukang vaginal effervescent tablets; Chinese patent CN 1927370 discloses a kind of Baofukang vagina soft capsule; Chinese patent CN1843489 discloses a kind of Baofukang vaginal capsule, but the above-mentioned improvement is still unsatisfactory

But still there are following deficiencies for Baofukang suppository: 1, the bioavailability of active drug is low; 2, easily pollute clothing; 3, use inconvenient; It is easy to become soft; 6. It dissolves slowly in the vagina; 7. Although the active ingredient is volatile, it still cannot be evenly distributed throughout the vaginal wall and cervix, and penetrates into the deep folds of the mucosa; 8. Polyethylene glycol is harmful to the body. Skin and mucous membranes are irritating and easy to absorb moisture

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