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Diglucoside, and preparation method and application thereof

A technology of disglycoside and extract, which is applied in the field of disoside and its preparation and use, and can solve problems such as no disoside and the like.

Inactive Publication Date: 2014-08-20
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on diglycosides as shown in structural formula (I) extracted and isolated from serum

Method used

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  • Diglucoside, and preparation method and application thereof
  • Diglucoside, and preparation method and application thereof
  • Diglucoside, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Take the serum powder, extract twice with 95% ethanol at 85°C under reflux, and recover the ethanol to obtain the extract;

[0031] (2) After suspending the obtained extract by adding an equal volume of distilled water, extract three times with petroleum ether, diethyl ether, ethyl acetate, and n-butanol, which are equal to the volume of the suspension, respectively, take the n-butanol part, and recover n-butanol under reduced pressure. butanol extract;

[0032] (3) Take the extract obtained in step (2) and add an equal volume of distilled water, then apply D101 macroporous adsorption resin, and perform gradient elution with ethanol with a concentration of 0%, 30%, 60%, and 90% for 3 times the column volume, respectively. , recovering 60% of the site extract, and then through silica gel short column chromatography, respectively, with different ratios of chloroform-methanol gradient elution, chloroform: methanol (15:1) to obtain the compound.

Embodiment 2

[0034] (1) Take the coarse powder of serum, extract it three times with 65% ethanol at 85°C, and recover the ethanol to obtain the extract;

[0035] (2) Suspend the obtained extract by adding an equal volume of distilled water, extract twice with petroleum ether, diethyl ether, ethyl acetate, and n-butanol, respectively, take the fraction of n-butanol, and recover under reduced pressure n-butanol extract;

[0036] (3) Take the extract obtained in step (2) and add an equal volume of distilled water, then apply D101 macroporous adsorption resin, and use 3.5 times the column volume of ethanol with a concentration of 0%, 30%, 60%, and 90% for gradient elution , recovering 60% of the site extract, and then through silica gel short column chromatography, respectively, with different ratios of chloroform-methanol gradient elution, chloroform: methanol (15:1) to obtain the compound.

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Abstract

The invention discloses diglucoside, and a preparation method and an application thereof. The preparation method of diglucoside comprises the steps that liparis nervosa of a liparis nervosa (thunb.) lindl. is adopted as a raw material, and subjected to alcohol extraction, organic solvent extraction, macroporous adsorbing resin elution and silica gel short-column chromatography. Experiments show that diglucoside can exert a hemostasia effect through affecting an extrinsic coagulation system.

Description

technical field [0001] The invention relates to a diglucoside extracted and separated from a medicinal material of blood serum, a preparation method and application thereof. Background technique [0002] The serum is the whole herb of the orchid plant Liparis nervosa (Thunb.) Lindl., also known as "Lidihao", "Black Orchid", and "Short Plump". It is cold in nature, bitter in taste, cools blood to stop bleeding, Detoxification. See serum often grows in damp places such as mountains and streams, and is distributed in Sichuan, Hubei, Taiwan and other places. At present, the folk medicinal materials are all wild. [0003] So far, there are few domestic and foreign research reports on serum, and the literature records are not exhaustive enough. In the research on the hemostasis of Jianserum, Zhou Jiming et al. used Jianserum and other medicinal materials to formulate prescriptions, and found that the compound Jianserum hemostatic drug had a significant hemostatic effect on 54 ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/203C07H1/08A61P7/04
Inventor 宋芹杨伟峰苟小军陈封政颜军郭晓强
Owner CHENGDU UNIV
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