Preparation method for functionality polyurethane degradable renovation materials used for tissue repair
A tissue repair and repair material technology, applied in medical science, prosthesis, etc., can solve problems such as poor compatibility and inability to achieve specific functions
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Embodiment 1
[0030] Mix 7.25mmol α-propargyl-δ-valerolactone with 3.625mmol ε-caprolactone, add 2.26mmol ethylene glycol and 0.0125mol stannous octoate, and react at 70°C for 1h to obtain a functional polyester soft segment. Add 2.712mmol of hexamethylene dicyanate and 0.01mol of stannous octoate to the soft segment of functional polyester and react at 70°C for 1 hour to form a prepolymer. Add 2.66mmol of ethylenediamine to the prepolymer for chain extension70 After reacting at ℃ for 7 hours, the functional polyurethane can be obtained by drying. Dissolve functional polyurethane in DMF, add terminal azidated RGD short peptide, add 0.07 mmol cuprous bromide, react at room temperature for 6 hours, then dry, wash monovalent copper ions with water and dry to obtain functional polyurethane degradable repair Material.
[0031] figure 1 The infrared spectrum of the functional polyurethane degradable repair material prepared for this example. and figure 2 Compared with the infrared spectrum o...
Embodiment 2
[0033] Mix 4.55mmol α-propargyl-ε-caprolactone with 136.5mmol lactide, add 5.26mmol 1,2-propanediol and 0.010mol stannous octoate, and react at 140°C for 12h to obtain a functional polyester soft segment. Add 11.046mmol of hexamethylene dicyanate and 0.01mol of dibutyltin dilaurate to the soft segment of functional polyester, react at 140°C for 12h to form a prepolymer, add 5.32mmol of ethylene glycol to the prepolymer After chain extension at 140°C for 12 hours, the functional polyurethane can be obtained by drying. Dissolve functional polyurethane in DMF, add terminal azidated RGD short peptide, add 0.105 mmol cuprous iodide, react at 60°C for 72 hours, then dry, wash monovalent copper ions with water and dry to obtain functional polyurethane degradable Restoration materials.
Embodiment 3
[0035]Mix 8.57mmol α-propargyl glycolide with 51mmol δ-valerolactone, add 5.91mmol 1,2-propanediol and 0.0225mol dibutyltin dilaurate, and react at 130°C for 5h to obtain a functional polyester soft segment. Add 8.15mmol tetramethylene diisocyanate and 0.005mol stannous octoate to the polyester soft segment and react at 120°C for 5 hours to form a prepolymer. Add 5.84mmol diethylene glycol to the prepolymer for chain extension After reacting at 130°C for 3 hours and then drying, the functional polyurethane can be obtained. Dissolve functional polyurethane in DMF, add end-group azidated HSNGLPL short peptide, add 0.0448 cuprous sulfate, react at room temperature for 16 hours, dry, and wash monovalent copper ions with water to obtain functional polyurethane degradable repair material.
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