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A kind of photoresponsive reversible chitosan hydrogel and preparation method thereof

A light-responsive chitosan technology, which is applied in the field of light-responsive reversible chitosan hydrogel and its preparation, can solve problems such as difficult mixing of glutaraldehyde and chitosan aqueous solution, a large number of gels, and poor gel uniformity. problem, achieve good biodegradability, accelerate healing, and reduce toxicity

Inactive Publication Date: 2015-12-09
YANCHENG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the formation of these chitosan hydrogels all need to add cross-linking agents such as glutaraldehyde etc. in addition, and the use of cross-linking agents has the following defects: (1) due to the cross-linking reaction between glutaraldehyde and amino groups on chitosan is extremely (2) Due to the high viscosity of the solution, it is difficult to remove a large number of air bubbles in the solution before the crosslinking reaction of the system occurs, resulting in a large number of pores inside the gel, and the coagulation The uniformity of the glue is very poor, and it is easy to break during the swelling process; (3) many drugs contain amino groups, and if the drug is loaded in situ, it is easy to react with glutaraldehyde; (4) glutaraldehyde is toxic and the residual Harmful to the human body
Recently, a UV light-induced cross-linked chitosan hydrogel has attracted a lot of attention, that is, introducing an azido group (azidobenzoic acid) on the amino group of chitosan to obtain a shell that can undergo photocross-linking. Glycan derivatives, the solution of which forms a hydrogel under ultraviolet light irradiation, but this hydrogel is not reversible, and its application as a bioadhesive material, tissue engineering and controlled release drug carrier has great limitations

Method used

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  • A kind of photoresponsive reversible chitosan hydrogel and preparation method thereof
  • A kind of photoresponsive reversible chitosan hydrogel and preparation method thereof
  • A kind of photoresponsive reversible chitosan hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Reversible preparation of light-responsive chitosan and its sol-gel

[0016] (1) Preparation of water-soluble carboxymethyl chitosan

[0017] 15g chitosan (M n =5.6×10 5 Da, DD=96%) and 200mL isopropanol are added in the dry three-necked bottle of 500mL, stirred to make chitosan evenly dispersed in isopropanol, 50% (50gNaOH+50gHO 2 O) 50 mL of NaOH solution was divided into 5 parts, one part was added every 30 min, and stirred at room temperature for 1 hour to obtain a reactant slurry. Dissolve 24g of solid chloroacetic acid in 70mL of isopropanol, and add it to the reactant slurry in 4 times. After the addition, the reactant was heated to 60° C. in a water bath, and the reflux condensing device was turned on under temperature control, and the reaction was stirred for 4 hours. Then the pH value was adjusted to 7-8 with glacial acetic acid, and a large amount of light yellow flocculent precipitates were precipitated, which was vacuum filtered to obtain a li...

Embodiment 2

[0025] Example 2 Reversible preparation of light-responsive chitosan and its sol-gel

[0026] (1) Preparation of water-soluble carboxymethyl chitosan

[0027] 20g chitosan (M n =5.6×10 5 Da, DD=96%) and 200mL isopropanol are added in the dry three-necked bottle of 500mL, stirred to make chitosan evenly dispersed in isopropanol, 50% (50gNaOH+50gHO 2 O) 60 mL of NaOH solution was divided into 3 parts, one part was added every 30 min, and stirred at room temperature for 1 hour to obtain a reactant slurry. Dissolve 30 g of solid chloroacetic acid in 80 mL of isopropanol, and add it to the reactant slurry in four portions. After the addition, the reactant was heated to 70° C. in a water bath, and the reflux condensing device was turned on under temperature control, and the reaction was stirred for 2 hours. Then the pH value was adjusted to 7-8 with glacial acetic acid, and a large amount of light yellow flocculent precipitates were precipitated, which was vacuum filtered to obt...

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Abstract

The invention belongs to the technical field of natural high polymer materials, and particularly relates to a photoresponsive reversible chitosan hydrogel and a preparation method thereof. The preparation method comprises the following steps: by using biocompatible natural high polymer chitosan as an initial material, carrying out chemical modification to respectively introduce carboxymethyl group and coumarin group to the 6-O position and 2-N position, thereby obtaining water-soluble photoresponsive reversible chitosan; and carrying out specific-wavelength ultraviolet irradiation on the photoresponsive reversible chitosan water solution with certain concentration to obtain the chitosan hydrogel. The hydrogel can be converted into sol under certain-wavelength ultraviolet irradiation. The photoresponsive reversible chitosan gel-sol conversion can be implemented by pure controllable ultraviolet irradiation, thereby avoiding using the biologically toxic chemical reagents, enhancing the biocompatibility and use compliance of the chitosan hydrogel, and making the clinical application of the chitosan hydrogel possible. The invention provides a new way for clinical application of the chitosan hydrogel.

Description

technical field [0001] The invention belongs to the technical field of natural polymer materials, and in particular relates to a light-responsive reversible chitosan hydrogel and a preparation method thereof. Background technique [0002] Chitosan is the only positive linear polysaccharide in nature. Its basic unit is glucosamine. It has the characteristics of good biocompatibility, no toxic and side effects, and rich sources. It has been used in the synthesis of food industry, pharmaceutical preparations, and medical polymer materials. fields have been widely developed and applied. Based on different mechanisms (covalent, ionic, hydrogen bonding), chitosan can form hydrogels, which have been reported by many. Chitosan can form chemical gels with glutaraldehyde, etc., and can also form physical gels with thioglycolic acid, acrylic acid, oxalic acid, etc. In addition, chitosan and metal ions or other biopolymers (for example: reduced gum, carrageenan, etc.) form ionic cross...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/28C08J3/24C08J3/075C08L5/08C08B37/08A61L15/28
Inventor 张怀红孙柏旺孙玉蔡照胜
Owner YANCHENG INST OF TECH
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