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Traditional Chinese medicine composition with lung cancer chemotherapeutic effect-enhancing and toxicity-reducing functions as well as preparation method and application thereof

A technology of attenuating toxicity and composition, which is applied in the application field of preparing synergistic and attenuated drugs for lung cancer chemotherapy, and can solve problems such as affecting curative effect, killing normal cells, and reducing quality of life

Inactive Publication Date: 2013-06-05
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemical drugs can not only inhibit cancer cells, but also kill normal cells, reducing the quality of life, and often due to different degrees of toxic and side effects, especially the toxicity of platinum-based drugs, some patients cannot successfully complete each course of treatment, which affects the curative effect

Method used

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  • Traditional Chinese medicine composition with lung cancer chemotherapeutic effect-enhancing and toxicity-reducing functions as well as preparation method and application thereof
  • Traditional Chinese medicine composition with lung cancer chemotherapeutic effect-enhancing and toxicity-reducing functions as well as preparation method and application thereof
  • Traditional Chinese medicine composition with lung cancer chemotherapeutic effect-enhancing and toxicity-reducing functions as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1: Accurately weigh 600g of rehmannia glutinosa, 80g of ginseng and 120g of Poria cocos, add 6400mL of water, soak for 30min, heat and reflux for 4h, filter, collect filtrate 1, add 6400mL of water to the filter residue, heat and reflux for 3h, filter, Collect the filtrate 2, combine the filtrate 1 and the filtrate 1, then add 300 mL of white honey, and concentrate until the thermal relative density is 1.2-1.6 kg / L (80°C), to obtain the compound composition, wherein the ginsenoside composition contains about 0.035%, the iridoid glycoside composition contains about 0.026%, 5-hydroxymethylfurfural contains about 0.013%, and the polysaccharide contains about 48%. In the compound composition, the ginsenoside composition: the iridoid glycoside composition: 5-HMF:polysaccharide=2.77:2.10:1.00:3823.36.

Embodiment 2

[0062] Example 2: Accurately weigh 712g of Rehmannia glutinosa, 98g of ginseng and 200g of Poria cocos, add 8000mL of water, soak for 30min, heat and reflux for 4h, filter, collect filtrate 1, add 8000mL of water to the filter residue, heat and reflux for 3h, filter, Collect the filtrate 2, combine the filtrate 1 and the filtrate 1, add 400mL white honey, and concentrate until the thermal relative density is 1.2-1.6kg / L (80°C), to obtain the compound composition, wherein the ginsenoside composition contains about 0.030%, the iridoid glycoside composition contains about 0.021%, 5-hydroxymethylfurfural contains about 0.008%, and the polysaccharide contains about 43.75%. In the compound composition, the ginsenoside composition: the iridoid glycoside composition: 5-HMF:polysaccharide=3.80:2.68:1.00:5574.67.

Embodiment 3

[0063] Example 3: Accurately weigh 900g of rehmannia glutinosa, 120g of ginseng and 280g of Poria cocos, add 10400mL of water, soak for 30min, heat and reflux for 4h, filter, collect filtrate 1, add 10400mL of water to the filter residue, heat and reflux for 3h, filter, Collect the filtrate 2, combine the filtrate 1 and the filtrate 1, add 500 mL of white honey, and concentrate until the thermal relative density is 1.2-1.6 kg / L (80°C), to obtain the compound composition, wherein the ginsenoside composition contains about 0.014%, the iridoid glycoside composition contains about 0.022%, 5-hydroxymethylfurfural contains about 0.004%, and the polysaccharide contains about 42.44%. In the compound composition, the ginsenoside composition: the iridoid glycoside composition: 5-HMF:polysaccharide=3.55:5.60:1.00:10532.23.

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition with lung cancer chemotherapeutic effect-enhancing and toxicity-reducing functions and a preparation method thereof and an application of the traditional Chinese medicine composition in preparation of lung cancer chemotherapeutic effect-enhancing and toxicity-reducing medicines. The composition consists of the following active pharmaceutical ingredients in parts by weight: 5-20 parts of rehmannia, 0.1-2 parts of panax ginseng, 0.5-4 parts of poria and 1-7 parts of white honey. The composition consists of four active ingredients namely ginsenoside composition, iridoid glycoside composition, 5-hydroxymethylfurfural and polysaccharide, and the mass ratio of the four active ingredients is (1.5-5.0):(1.0-8.0):(0.2-1.0):(3000-15000). The obtained composition has an obvious synergism effect in cis-dichlorodiamineplatinum (II) chemotherapy of experimental mice suffering from lung cancer and an obvious inhibition function of myelosuppression caused by cis-dichlorodiamineplatinum (II) chemotherapy.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound composition for synergizing and attenuating toxicity of lung cancer chemotherapy, a preparation method thereof and its application in the preparation of synergizing and attenuating drugs for lung cancer chemotherapy. Background technique [0002] Lung cancer is a common malignant lung tumor. In recent years, with the influence of smoking and various environmental factors, the morbidity and mortality of lung cancer have risen rapidly in countries all over the world, especially in industrialized countries. The rate of two "first" malignant tumors seriously threaten people's health and lives. Despite great advances in the treatment of other cancers, the mortality rate from lung cancer remains high. Therefore, it is of great significance to research and develop lung cancer synergistic and attenuated drugs. [0003] Current treatments for lung cancer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P11/00A61P35/00A61K35/64A61K35/644
Inventor 李松林徐金娣
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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