A water-in-oil type emulsion for treating a disease of the eye
A technology for eye diseases and emulsions, which is applied in the field of treatment of eye diseases or diseases, and can solve the problems that biological agents cannot be selected
Inactive Publication Date: 2015-07-15
SANTEN SAS
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Problems solved by technology
However, this form of administration introduces solids in the patient's eye, which is undesirable in some cases
Furthermore, this approach is more suitable for the administration of lipophilic rather than hydrophilic agents and cannot be selected for the administration of biological agents such as proteins and monoclonal antibodies
Method used
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[0058] The present invention thus relates to a composition for use in the treatment of ocular diseases or conditions by the intraocular route, wherein the composition is a water-in-oil emulsion comprising an oil phase, a lipophilic surfactant dissolved in the oil phase, An aqueous phase dispersed in an oil phase and a hydrophilic therapeutic agent dissolved in the dispersed aqueous phase, the composition has a density of less than 1, a viscosity in the range of 25 to 10000 mPa.s at 20°C, wherein the average of the water droplets The size ranges from 20nm to 600nm, the composition sustainably releases the hydrophilic therapeutic agent, and wherein the use by the intraocular route is intraocular injection.
[0059] In one embodiment of the invention, the oily phase of the water-in-oil emulsion comprises an oil selected from the group comprising: triglycerides, such as semi-synthetic oils: medium chain triglycerides (MCT) or long chain triglycerides; monoglycerides; diglycerides;...
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Abstract
The invention relates to a composition for administering with a sustained release kinetic a therapeutically effective amount of a therapeutic agent to a subject in need thereof for treating diseases or conditions of the eye, wherein the composition is an water-in-oil type emulsion comprising an oil phase, a lipophilic surfactant dissolved in the oil phase, an aqueous phase dispersed in the oil phase, a hydrophilic therapeutic agent dissolved in the aqueous dispersed phase, and wherein the composition is intraocularly injectable, wherein the composition has a density lower than 1. The invention also relates to a pharmaceutical composition or to a medicament comprising the composition of the invention, and to a method for treating a condition or disease of the eye comprising administering a therapeutic amount of the composition of the invention. The invention also relates to a device comprising the composition of the invention.
Description
technical field [0001] The present invention relates to the field of treatment of ocular conditions or diseases by intraocular administration of therapeutic agents. Background technique [0002] Treatment of eye diseases by injecting therapeutic agents directly into the vitreous cavity has shown promising results in the past. (oligonucleotides) and (monoclonal antibodies) are medicinal products that can effectively treat retinal diseases. [0003] However, their relatively short half-life in the vitreous results in the need for repeated injections to maintain effect. Because the vitreous humor is renewed over time, these products are cleared quickly. [0004] This problem has been addressed in the prior art: for example, WO2009 / 046198 describes a method for administering a therapeutic agent in the vitreous with sustained release kinetics; gelatinous structure. Additionally, EP2187980 describes the injection of a therapeutic agent in the vitreous cavity in combination ...
Claims
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IPC IPC(8): A61K9/00A61K9/107A61K47/14
CPCA61K9/0048A61K9/107A61P27/02A61P27/06A61K47/14
Inventor 弗里德里克·拉伦曼德让-塞巴斯蒂安·加里格贝蒂·菲利普斯
Owner SANTEN SAS