Oxybutynin transdermal gel and preparation method thereof

A gel and transdermal technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as adverse effects on the skin, and achieve improved clinical treatment effects, no foreign body sensation, and good air permeability. Effect

Inactive Publication Date: 2013-06-19
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem that cannot be ignored is that the mechanism of action of penetration enhancers is usually to change the structure of the skin itself to achieve the effect of penetration enhancement. The adverse effects of long-term application of penetration enhancers on the skin are obvious.

Method used

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  • Oxybutynin transdermal gel and preparation method thereof
  • Oxybutynin transdermal gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The present embodiment is the preparation of the oxybutynin hydrochloride gel that main ingredient content is 1%:

[0041] prescription composition Prescription amount Oxybutynin Hydrochloride 1g Absolute ethanol 70g HPMC E4M 1.5g glycerin 2g sodium hydroxide Appropriate amount purified water Add to 100g

[0042] Preparation method: HPMC E4M is passed through a 80-mesh sieve, oxybutynin hydrochloride is dissolved in 30% prescription amount of absolute ethanol to form an ethanol solution of oxybutynin hydrochloride, and NaOH is prepared with purified water to make a 5mol / L NaOH solution for later use; Appropriate amount of purified water, add HPMC E4M into water to make it swell into a uniform colloid, add glycerin, 70% prescription amount of absolute ethanol and oxybutynin hydrochloride ethanol solution respectively under stirring, after mixing evenly, add NaOH solution to adjust When the pH value reaches 5.6, add th...

Embodiment 2

[0044] The present embodiment is the preparation of the oxybutynin hydrochloride gel that main ingredient content is 10%:

[0045] prescription composition Prescription amount Oxybutynin Hydrochloride 10g Absolute ethanol 70g HPMC E4M 1.5g glycerin 2g sodium hydroxide Appropriate amount purified water Add to 100g

[0046] Preparation method: HPMC E4M is passed through a 80-mesh sieve, oxybutynin hydrochloride is dissolved in 30% prescription amount of absolute ethanol to form an ethanol solution of oxybutynin hydrochloride, and NaOH is prepared with purified water to make a 5mol / L NaOH solution for later use; Appropriate amount of purified water, add HPMC E4M into water to make it swell into a uniform colloid, add glycerin, 70% prescription amount of absolute ethanol and oxybutynin hydrochloride ethanol solution respectively under stirring, after mixing evenly, add NaOH solution to adjust When the pH value reaches 5.6, add ...

Embodiment 3

[0048] The present embodiment is the preparation of the oxybutynin hydrochloride gel that main ingredient content is 30%:

[0049] prescription composition Prescription amount Oxybutynin Hydrochloride 30g Absolute ethanol 50g HPMC E4M 1.5g glycerin 2g sodium hydroxide Appropriate amount purified water Add to 100g

[0050] Preparation:

[0051] HPMC E4M passes through a 80-mesh sieve, dissolves oxybutynin hydrochloride in 30% prescription amount of absolute ethanol to form an ethanol solution of oxybutynin hydrochloride, and NaOH is prepared with purified water to make a 5mol / L NaOH solution for later use; take an appropriate amount of purified water , add HPMC E4M into water to make it swell into a uniform colloid, add glycerin, 70% prescription amount of absolute ethanol and oxybutynin hydrochloride ethanol solution respectively under stirring, after mixing evenly, add NaOH solution to adjust the pH value to 5.6, add the ...

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Abstract

The invention relates to a transdermal gel of oxybutynin or a pharmaceutically acceptable salt thereof used for treating overactive bladder with the symptoms of frequent urination, urgent urination and urinary incontinence, and a preparation method of the transdermal gel. The transdermal gel comprises oxybutynin or the pharmaceutically acceptable salt thereof, a gel matrix hydroxypropyl methylcellulose, a pH value regulator, a humectants and a solvent of anhydrous ethyl alcohol and water.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions or preparations, in particular to oxybutynin or a pharmaceutically acceptable salt thereof for treating overactive bladder (Overactive Bladder, OAB) with frequent urination, urgency and incontinence as symptoms A transdermal gel and a preparation method thereof, the transdermal gel mainly consists of oxybutynin or a pharmaceutically acceptable salt thereof, a gel base, a pH regulator, a moisturizing agent and a solvent. Background technique [0002] OAB is a syndrome characterized by symptoms of urinary urgency, which is a sudden and strong desire to urinate, and it is difficult to delay urination by subjective suppression. Or without urge incontinence; urodynamically, it can be manifested as detrusor overactivity or other forms of urethral-bladder dysfunction. Frequent urination refers to the patient consciously urinating too frequently every day. On the basis of subjective feelings, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/216A61P13/10
Inventor 钟晓东张涛王立
Owner CHONGQING PHARMA RES INST
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