Novel application of Arctigenin in preparation of anti-arrhythmia medicine

A technology of arctigenin and arrhythmia, which is applied in the field of arctigenin anti-arrhythmia, a known Chinese medicine extract, and can solve problems affecting ion channels

Inactive Publication Date: 2013-06-19
NANKAI UNIV +1
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, drugs that affect ion channels, especially with bidirectional regulation of arrhythmias, have been rare to date.

Method used

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  • Novel application of Arctigenin in preparation of anti-arrhythmia medicine
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  • Novel application of Arctigenin in preparation of anti-arrhythmia medicine

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Experimental program
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Effect test

Embodiment 1

[0041] The applicant found that arctigenin has the following effects in addition to the known effects in the patch clamp test of the action of arctigenin on the ion channel of rat cardiomyocytes:

[0042] (1) Reduce myocardial cell calcium current;

[0043] (2) Reduce the increase of calcium current in cardiomyocytes caused by aconitine, and resist the arrhythmia caused by aconitine;

[0044] (3) Antiarrhythmic effect caused by ouabain;

[0045] (4) Increase the transient outward potassium current of cardiomyocytes;

[0046] (5) Inhibit cardiomyocyte sodium current;

[0047] (6) Weaken the contractility of the heart and slow down the heart rate;

[0048] Therefore, arctigenin is a drug with clinical application value in the future.

[0049] 1. The effect of arctigenin on the contractility of rat cardiomyocytes induced by aconitine.

[0050]The preparation method of the isolated working heart refers to the reference document "Study on the Positive Inotropic Effects of Acon...

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Abstract

The invention discloses a novel application of a traditional Chinese medicine extract product-Arctigenin in preparation of anti-arrhythmia medicines. A research found that the Arctigenin has bidirectional anti-arrhythmia effect and can adjust arrhythmia caused by aconitine and ouabain. Arctigenin has an effect for reducing ventricular muscle contraction force. A pharmacological effect of the Arctigenin is bidirectional adjusted cardiac muscle cell inner calcium current, the cardiac muscle cell inner potassium current is increased, and the sodium current is inhibited. The invention shows that the Arctigenin has anti-arrhythmia effect, and especially has bidirectional adjusting on arrhythmia, the side-effect is smaller, the Arctigenin has application prospect for treating toxic arrhythmia and ischemic-reperfusion arrhythmia in aconitine and ouabain; and the Arctigenin with myocardial contractility reduction effect can be taken as an auxiliary treatment measurement for hypertensive disease.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract and its use, in particular to the use of a known traditional Chinese medicine extract—arctigenin in resisting arrhythmia. Background technique [0002] Cardiac arrhythmia is a common and frequently-occurring disease in the field of cardiovascular diseases, and its mechanism can be summarized as abnormal impulse formation, abnormal conduction, or both abnormal impulse formation and conduction. [0003] "Research Progress on the Pathogenesis of Cardiac Arrhythmia" and other literatures have reported that arrhythmia is one of the most serious diseases in the cardiovascular system diseases. The danger of arrhythmia is that it can not only aggravate the original heart disease, such as accelerating the progress of heart failure, but also lead to sudden death of the patient, which seriously threatens human health. Ischemic heart disease is the main cause of malignant arrhythmias such as ventricu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P9/06
Inventor 赵振营白钢吴红罗国安娄建石尹永强姜民侯媛媛
Owner NANKAI UNIV
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