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A novel strain of lactobacillus Reuteri for use by improving autoimmune diseases

An autoimmune disease, lactobacillus technology, applied in bone diseases, allergic diseases, medical preparations containing active ingredients, etc., can solve problems such as abnormal function, unable to regulate the immune system normally, attack, etc.

Active Publication Date: 2014-12-24
BIO RAY BIOTECH
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  • Description
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Problems solved by technology

[0005] The second reason is that the normal and hidden antigens in the body are released, and the immune system regards them as foreign pathogens and attacks them
The third reason is that regulatory T cells (Regulator T ce11, T reg), which regulate the normal operation of the immune system, have abnormal functions and cannot normally regulate the immune system.

Method used

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  • A novel strain of lactobacillus Reuteri for use by improving autoimmune diseases
  • A novel strain of lactobacillus Reuteri for use by improving autoimmune diseases
  • A novel strain of lactobacillus Reuteri for use by improving autoimmune diseases

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Embodiment Construction

[0046] In order to further illustrate the technical means and effects that the present invention takes to achieve the intended purpose of the invention, below in conjunction with the accompanying drawings and preferred embodiments, the novel Lactobacillus rhodus strain proposed according to the present invention and its application to improve autoimmune diseases The specific implementation, structure, method, steps, features and effects of the application are described in detail below.

[0047] 1. Identification of novel microorganism BR101

[0048] A single colony was isolated using the screening medium, and the appearance of the colony and the results of Gram staining were observed, and the sequence alignment of the 16S rDNA gene fragment showed that the isolated strain BR101 was Lactobacillus reuteri.

[0049] 1.1 Colony appearance and Gram staining microscopic examination

[0050] The BR101 bacterial strain of the present invention utilizes neonatal feces specimens, uses ...

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Abstract

The invention relates to a separated novel strain BR101. The strain is separated from the stool specimens of new born baby. The stain is identified as Lactobacillus Reuteri after identifying strain characteristics and comparing sequence of 16s rDNA. Based on colony appearance, gene sequence difference of 16S rDNA, analysis to extended various DNA for random primer, AP150CHL microorganism sugar biochemical reaction, screening and stipulating IL-10 and its function analysis, the strain of BR101 is significant different from other strains. In addition, the strain of BR101 can stipulate cells generating more anti-inflammation hormone to decrease the autoimmunization inflammation reaction to improve symptoms of autoimmunization inflammation diseases.

Description

technical field [0001] The present invention relates to a novel bacterial strain isolate BR101, in particular to a newborn feces sample, which is identified as Lactobacillus rhodus strain by comparing the sequence of 16S rDNA gene fragments, and is compared with other Lactobacillus rhodes Bacillus standard strains were compared, showing that the strain BR101 is significantly different from other standard strains, and has the ability to stimulate cells to produce higher anti-inflammatory hormones, reduce autoimmune inflammatory reactions, and achieve the novel Lactobacillus reuteri that improves autoimmune diseases strain. It was deposited on September 24, 2012 at the General Microorganism Center of China Microbiological Culture Collection Management Committee, address: No. 3, Yard No. 1, Beichen West Road, Chaoyang District, Beijing, China, deposit number CGMCC No.6637, and also deposited in China Taiwan Food Industrial Development Research Institute, deposit number BCRC91051...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/74A61P37/02A61P29/00A61P19/02A61P19/04A61P19/08C12R1/225A61K35/747
Inventor 许清祥吕春美李欣桦王樱谕薛如婷赖订颖
Owner BIO RAY BIOTECH
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