Yinchengao Decoction formula particles, and preparation method and detection method thereof

A technology of formula granules and Yinchenhao Decoction, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, measuring devices, etc., can solve the problem that the quality cannot be well controlled, the Yinchenhao Decoction formula granules cannot be used safely, etc. question

Inactive Publication Date: 2013-08-07
KANGMEI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Therefore, the object of the present invention is to provide a Yinchenhaotang formula granule and its preparation method and detection method for the problem that the Yinchenhaotang formula granule cannot be used s

Method used

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  • Yinchengao Decoction formula particles, and preparation method and detection method thereof
  • Yinchengao Decoction formula particles, and preparation method and detection method thereof
  • Yinchengao Decoction formula particles, and preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1 Selection of Preparation Conditions for Yinchenhaotang Formula Granules

[0094] 1. Medicinal materials

[0095] Capillary Artemisia, Gardenia and Rhubarb slices.

[0096] 2. Instruments and equipment

[0097] Electronic scale (model: UWA-F-003, Xiamen Lianmao Electronics Co., Ltd.); electric heating mantle (specification: 10000ml, Haining Xinhua Medical Instrument Factory); rotary evaporator (model: RE-5205, Shanghai Yarong Biochemical Instrument Factory) ; Circulating water vacuum pump (model: SHZ-D (Ⅲ), Gongyi Yingyu Yuhua Instrument Factory); Halogen moisture analyzer (model: HB43-S, Mettler-Toledo); high performance liquid chromatography : Waters2695-2489, Empower2Personal Single System SW Chemical Workstation; Column: Waters C18 (4.6mm×250mm, 5μm); electronic analysis equipment: METTER TOLEDO XP6; HANGPING FA2104; ultrasonic extractor: KQ-300VDB dual-frequency digital control ultrasonic cleaner. Methanol is chromatographically pure, water is ultra...

Embodiment 2

[0130] Example 2 Preparation of Yinchenhaotang Formula Granules

[0131] According to the prescription, take 180g, 90g, and 60g of Artemisia capillaris, gardenia, and rhubarb decoction pieces that meet the requirements of the Pharmacopoeia, put the medicinal materials into a round bottom flask, add 6 times the amount of water of the total amount of medicinal materials, soak for 30 minutes, and decoct to extract Three times, the first time add 8 times the amount of water to extract for 30 minutes, filter, and the filtrate is collected in another device; the second time, add 6 times the amount of water to extract for 15 minutes, filter, and the filtrate is collected in another device, and the third time add 6 times the amount of water Extract for 10 minutes, combine three filtrates; concentrate the filtrate under reduced pressure at 65-75°C to 1.05-1.20, microwave-dry, collect the obtained dry extract, dry-compress granules, and pack separately to obtain Yinchenhaotang formula ...

Embodiment 3

[0132] Example 3 Preparation of Yinchenhaotang Formula Granules

[0133] According to the prescription, take 180g, 90g, and 60g of Artemisia capillaris, gardenia, and rhubarb decoction pieces that meet the requirements of the Pharmacopoeia, put the medicinal materials into a round bottom flask, add 8 times the amount of water of the total amount of medicinal materials, soak for 30 minutes, and decoct to extract Three times, the first time add 8 times the amount of water to extract for 30 minutes, filter, and the filtrate is collected in another device; the second time, add 6 times the amount of water to extract for 20 minutes, filter, and the filtrate is collected in another device, and the third time add 6 times the amount of water Extract for 15 minutes, combine three filtrates; concentrate the filtrate under reduced pressure at 70-72°C to 1.10-1.15, microwave-dry, collect the obtained dry extract, dry-compress granules, and pack separately to obtain Yinchenhaotang formula ...

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Abstract

The invention provides Yinchengao Decoction formula particles, and a preparation method and detection method thereof. The preparation method comprises the following steps: extracting Yinchengao, gardenia and rhubarb with water, filtering, concentrating and carrying out spray drying to obtain the Yinchengao Decoction formula particles. The detection method of the Yinchengao Decoction formula particles comprises the following steps: identifying the Yinchengao Decoction formula particles by thin-layer chromatography; determining the fingerprint of the Yinchengao Decoction formula particles by high-performance liquid chromatography; determining the substance content in the Yinchengao Decoction formula particles by high-performance liquid chromatography; determining the extract content in the Yinchengao Decoction formula particles by a hot dipping method; determining the heavy metal content in the Yinchengao Decoction formula particles by a residue ignition inspection method; and determining the residue content of organo-chlorine pesticide in the Yinchengao Decoction formula particles by a pesticide residue determination method.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine. It specifically relates to a traditional Chinese medicine and its preparation method and detection method, in particular to a Yinchenhaotang formula granule and its preparation method and detection method. Background technique [0002] Yinchenhao Decoction is derived from "Treatise on Febrile Diseases": "Yangming disease, fever and sweating, this is hot and can not turn yellow." For those, Yinchenhao Decoction is the main one.” Yinchenhao Decoction is composed of three herbs: Artemisia yinchen, Fructus Sinensis and Rhubarb. [0003] Yinchenhao Decoction is mainly used to treat jaundice due to damp heat, yellow skin and face, bright orange color, slightly full abdomen, thirsty mouth, difficulty urinating, yellow and greasy tongue coating, heavy or slippery pulse. Yinchen clears away heat and dampness, soothes the liver and gallbladder as king; Zhizi clears away dampness and heat in th...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/16A61P31/04G01N30/02G01N30/90G01N30/36G01N30/06
Inventor 韦冬菊许冬瑾马兴田向飞军吴小明陈有军
Owner KANGMEI PHARMA
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