Plasma exchange absorption filter purifying system with square plasma storage tank

Abstract

The invention discloses a plasma exchange absorption filter purifying system with a square plasma storage tank. The plasma exchange absorption filter purifying system comprises a fractional plasma separation feedback circulating part and a plasma purification regeneration circulating part. A selective membrane plasma separator is used to separate fractional plasma, flow rate difference of plasma separation circulating and plasma purification circulating is built by the special square plasma storage tank, two-stage purification is arranged before and after the square plasma storage tank during purification circulating, primary bilirubin absorption columns are arranged before the square plasma storage tank, a high-pass filter and an activated carbon absorber are arranged after the square plasma storage tank for absorption filter purification, and plasma after multiple circulations is fed back to human bodies by means of separation feedback circulation exchange. By the system, autologous waste plasma generated during plasma exchange purification can be purified continuously, plasma use is reduced. By the two-stage absorption filter system, small molecules, medium-sized molecules, inflammatory factor combined with proteins and large-molecule toxin and the like which are generated by liver failure can be eliminated, and system purification efficiency can be increased.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, relates to a medical device and an application method thereof, in particular to a blood purification system which adopts a combination of replacement, adsorption and filtration technologies and an application method thereof. Background technique [0002] The blood purification technology for artificial liver replacement therapy is developing rapidly. At present, the domestic treatment is dominated by component plasma exchange, while the research hotspot abroad is the albumin dialysis adsorption system. The representative method is the molecular adsorption recirculation system (MARS). The basic principle of this type of method is to use albumin solution as the dialysate in the protein dialysis cycle, so that the protein-bound toxins and other types of toxin molecules in the patient's blood are transferred to the albumin solution through the MARS dialysis membrane, so that the blood can be...

AI Technical Summary

Problems solved by technology

This system is improved on the basis of the MARS system, but still uses the albumin dialysis method of MARS, and the exchange efficiency of the membrane is too low. Even if the subsequent purification method is improved, the purification effect is still limited

[0004] The Prometheus system, which is similar to the MARS treatment system, separates and absorbs the component plasma and then performs hemodiafiltration. Compared with the MARS system, the amount of albumin is greatly reduced, but the plasma separator is connected in series with the hemofilter, which greatly increases the system cost. Operational instability, difficult clinical operation, and extracorporeal circulation capacity of at least 600ml, have a great impact on the hemodynamics of critically ill patients, so it has not been widely used at home and abroad

[0005] Domestically, the method of plasma exchange is widely used. At present, the supply of plasma is extremely short, and a plasma exchange needs to use about 3000ml of fresh plasma, and the replaced 3000ml of plasma is discarded, and a large number of beneficial components cannot be effectively reinfused and utilized. At present, there is no efficient way to recycle these waste plasma. If the waste plasma can be fully utilized for purification and then replaced by itself, it can greatly reduce the amount of clinical plasma used and effectively treat more patients.

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