42 results about "Plasma Exchanges" patented technology

Disclosed herein are methods for treating amyloid disease in humans by clearing amyloid peptides from one or more bodily fluids such as, e.g., blood, of a patient. In particular, the methods are based on the administration capable of binding to amyloid-beta (Aβ) or on dialysis of blood or plasma exchange in order to remove Aβ peptides from the blood circulation, and/or brain or other affected organs.

The invention discloses a plasma exchanging adsorption filtration purification system provided with a plasma storage bag and an application method of the purification system. The method includes two steps of plasma components separation returning cycle and high-speed plasma purification regeneration cycle. Plasma components are separated by a selective membrane plasma separator; flow speed difference between a plasma separation cycle and a plasma purification circle is set by the specific plasma storage bag; high-speed plasma adsorption filtration purification treatment is performed by a high-throughput filter and an active carbon-resin absorptive device in a purification circle; and plasma subjected to cycle treatment for multiple times can be exchanged back to a human body through the separation returning circle. By the aid of the purification system and the application method thereof, autologous plasma waste generated in a plasma exchanging purification process can be purified continuously and effectively, and plasma consumption is reduced. The high-throughput filter and an adsorption column are connected in series to purify the plasma; load on a subsequent adsorber is reduced; and varied inflammatory factors, macromolecular toxins and the like combined by micromolecules, middle molecules and proteins which are generated from hepatic failure are eliminated as well, so that the purification efficiency of the whole system is greatly improved.

It is intended to provide a molding method whereby a body fluid purification cassette having a minimized size can be formed at a low cost. A body fluid purification cassette (U1), which is mounted toa body fluid purification apparatus body in a detachable manner, is composed of synthetic resin housings (F1, F2), fundamental elements (R1, 1, PT1) to be enclosed in the housings, selected element(s)(2) that are selected as necessary from among body fluid purification elements such as a dialyzer (2), a plasma exchange module and an immunoadsorption column, and body fluid channels (R1 to R7) connecting the fundamental elements to the selected element(s). The housings (F1, F2) and the body fluid channels (R1 to R7) are molded by the primary molding so that the halved cross section has a definite shape. Then, the halved constructs are integrated together by the secondary molding to give a cassette. In the step of integrating the body fluid channels in the halved constructs via the secondarymolding, the fundamental elements (R1, 1, PT1) and the selected element (2) are liquid-tightly connected to the body fluid channels (R1 to R7).

The invention relates to an in vitro supporting device for a mixed biological artificial liver temporarily replacing the liver function of human body. The structure of the in vitro supporting device for the mixed biological artificial liver is as follows: a bioreactor in an incubator is connected with a reactor circulating pump and a membrane lung which is connected with an exchange column; the exchange column is connected with the reactor circulating pump; a blood pump is connected with a blood inlet and a separation tube; a blood plasma infusion pump is connected with a tee joint and an active carbon absorption column; a biological artificial liver pump is connected with the active carbon adsorption column and the exchange column; a dialysis pump is connected with the exchange column and a dialysis tube; the separation tube is connected with a blood pool and the tee joint which is connected with a discarded blood plasma reservoir and the blood plasma infusion pump; the active carbon adsorption column is connected with the artificial liver pump; the dialysis pump is connected with the blood pool, a dialyzate bag and a waste fluid reservoir; and the blood pool is connected with a blood outlet. The in vitro supporting device for the mixed biological artificial liver solves the respective defects of a non-biological artificial liver and a biological artificial liver, organically combines the non-biological artificial live and the biological artificial liver to generate synergistic reaction, and achieves the aims of plasma exchange, plasma infusion, biological artificial liver dialysis and hemodialysis.

The invention provides a blood composition acquisition device and method. The blood composition acquisition device comprises a blood collector (1), a whole blood pump (14), a blood composition separation cup (17), a first plasma transfer bag (24), a blood platelet collecting bag (29) and a red blood cell transfer bag (30). The blood collector (1), the whole blood pump (14) and the blood composition separation cup (17) are sequentially connected through pipelines, and the blood composition separation cup (17) is connected with the first plasma transfer bag (24), the blood platelet collecting bag (29) and the red blood cell transfer bag (30) through pipelines. Collection of multiple blood compositions such as plasma, blood platelets and red blood cells can be achieved at a time through the same set of device consumables without conducting multiple times of vein vessel puncture on blood members, plasma exchange, red blood cell washing and other work can be completed, blood waste is reduced, the contamination phenomenon is avoided, the collecting working efficiency of the blood compositions is improved, and the labor intensity of medical staff is reduced.

The invention discloses a plasma storage bag special for plasma exchange, absorption, and filtration treatment. The plasma storage bag comprises a plasma storage bag body and auxiliary connecting pipelines. The plasma storage bag body comprises an outer bag and an inner bag, and inner and outer cavities are connected with each other through a one-way valve composed of a double-layered membrane. A separated-plasma inlet communicated with the outer cavity and a purified-plasma inlet communicated with the inner cavity are reserved at the top of the plasma storage bag. A backflow-plasma outlet served as an outflow outlet for the inner cavity and a purified-plasma outlet served as an outflow outlet for the outer cavity are reserved at the bottom of the plasma storage bag. By the arrangement, the problem that extracorporeal circulation capacity jointed by complex treatment is larger is solved, and treatment is safer and more convenient; and by design of the inner and outer cavities and a structure of liquid velocity difference in operation, plasma of a patient with liver failure goes through multiple times of extracorporeal absorption and filtration purifying circulations, efficient circulation passages can be formed, inefficient circulations can be avoided, and better treatment effect can be exerted.

A microbubble reducer for eliminating and/or removing bubbles of gas from a flow comprising non-Newtonian fluids, wherein the microbubble reducer comprises an inlet at a low point, a curved duct means comprising a gas outlet at a high point, an outlet at a low point, and a lumen that runs through said inlet, said curved duct means, said gas outlet, and said outlet. Additionally, including various methods for removing gas from a flow comprising non-Newtonian fluid(s) using the microbubble reducer, an apparatus comprising the microbubble reducer, and uses of the microbubble reducer pertaining to dialysis or similar treatments, inter alia hemodialysis, plasma exchange, for infusion of blood and other non-Newtonian fluids, and in a heart-lung machine.

The invention discloses a plasma exchanger device. The plasma exchanger device comprises a fixed shell, wherein a plasma exchange space is formed in the left side of the interior of the fixed shell; apower storage device is fixedly arranged in the left end wall of a transmission space, and the right end of the power storage device is electrically connected with a first electric conduction block through a first wire; the lower end of a semiconductor generator is electrically connected with a second electric conduction block through a second wire which is connected in parallel; the upper end ofthe semiconductor generator is electrically connected with the power storage device through a third wire which is connected in parallel; a pressurizing device is arranged at the left end surface of the fixed shell; and a closing device is arranged at the rear end wall of the plasma exchange space. In the working process, the handheld jetting of the plasma is realized, and the use is convenient; when the temperature or the pressure value exceeds the standard, a driving motor is controlled to work, and the power supply is disconnected, so that the safety of the device is ensured, wherein a closing plate and a sealing plate can be opened, so that maintenance or replacement of the device in the plasma exchange space is facilitated, and the device is convenient to use.

A person who is used in the field of medicine- Preparation of human cell fusion maternal-fetal blood group incompatibility therapy hybrid strain, characterized by, Using erythropoietin as inducer, ''O'' type human bone marrow cell positive for Rh were cultured, to increase the number of directionally developing erythroid cells, human bone marrow cells and human myeloma cells were fused into hybridized cells, Erythropoietin was use to induce that directional differentiation of the hybridized cell, Hybrid cell clones were screened by HAT, The hybridization strains of Rh positive cells which canbe expanded indefinitely in vitro were screened by Rh antibody, As that adsorbent aft industrialized amplification, A low-cost and safe method for that treatment of maternal-fetal blood group incompatibility hemolytic disease without plasma exchange solution without remove plasma and its beneficial ingredients is create by absorbing pathogenic Rh antibody in peripheral plasma of pregnant women with maternal-fetal blood group incompatibility through an in vitro adsorption device which is formed by an adsorber and a blood separator.

The invention discloses a plasma exchange and adsorption system. The system comprises a plasma separator, a plasma collection pipeline, a first blood pump, a waste liquid bag, an exchange liquid bottle/bag, a first plasma storage bottle/bag, and a second plasma storage bottle/bag; and the output end of the plasma collection pipeline is connected to the input end of the plasma separator, the outputend of the plasma separator is connected to the waste liquid bag, the exchange liquid bottle/bag, the first plasma storage bottle/bag and the second plasma storage bottle/bag through a pipeline, andthe first blood pump is arranged on the plasma collection pipeline. According to the system, plasma exchange, plasma adsorption and plasma dialysis are combined, the therapeutic advantages of variousplasma purification technologies can be fully exerted, and requirements of current plasma purification equipment can be met.

The invention provides an uninterrupted plasma supply device for plasma exchange in extracorporeal circulation blood purification, and belongs to the technical field of medical instruments. The uninterrupted plasma supply device comprises a supporting plate, a blood transfusion bag, a liquid collecting box, blood transfusion tubes and blood control mechanisms, wherein the supporting plate is vertically arranged on a blood transfusion frame; the blood transfusion bag, the blood transfusion tubes and the liquid collecting box are sequentially connected in series; the blood control mechanisms areused for controlling blood plasma flow and on-off in the blood transfusion tubes; and the multiple blood control mechanisms are matched to enable blood plasma in the blood transfusion tubes to be sequentially conveyed to the liquid collecting box. By the uninterrupted plasma supply device for plasma exchange in extracorporeal circulation blood purification, continuous plasma exchange can be carried out for a patient; in the process, frequent pause of blood flow in the blood purification loop due to blood plasma exchange is avoided, blood coagulation is prevented, the risk of interruption or failure of blood purification is greatly reduced, the workload of medical staff is reduced, the operation is simple, the overall time of blood purification is shortened, the risk of extracorporeal circulation of a patient is reduced, and the pain of the patient is relieved.

The invention discloses a lipid blood specimen treatment device for blood routine examination. The device comprises a case, a condensation box is fixedly mounted at the upper end of the case, a bottomplate is fixedly mounted on the lower side of the right end of the case, a centrifugal device is arranged in the case, and a placement rack is fixedly connected to the upper end of the centrifugal device. A sampling pipe is movably inserted into the upper end of the placement frame, a plasma storage part is fixedly installed on the right portion of the upper end of the condensation box, a mixingdevice is fixedly installed on the right portion of the upper end of the bottom plate, and a normal-temperature treatment device is fixedly installed at the upper end of the mixing device. According to the lipid blood specimen treatment device for blood routine examination, blood plasma of normal people of the same blood type and blood with fat on the upper layer removed are mixed and equivalentlyreplaced, the situation that fat particles influence the detection process is avoided, and the hemolysis phenomenon generated after blood plasma replacement of specimens is avoided; and the plasma storage part and a measuring cylinder are matched for use, so that the plasma exchange work is quick and convenient, and an extraction part can improve the lipid blood treatment effect.

Techniques for treating cancer are provided. The techniques include obtaining an amount of serum and/or plasma from at least a first patient with a given type of cancer and administering at least a portion of the serum and/or plasma obtained from the first patient to at least a second patient with the same or different type of cancer. Administering the serum and/or plasma obtained from the first patient to the second patient includes administering a therapeutically effective amount of one or more immunoglobulins and one or more soluble receptors corresponding to each immunoglobulin so as to enable reconstitution of a humoral immune system of the second patient to thereby treat the cancer in the second patient.

The invention relates to a peripheral vein fixing compressor for plasma exchange, which belongs to the technical field of medical instruments. The peripheral vein fixing compressor comprises a supportplate and a fixing component, the support plate is a rectangular plate made of hard materials, and the fixing component comprises a first fixing band arranged on the front end of the rectangular plate and a second fixing band arranged on the rear end of the rectangular plate, the first fixing band and the second fixing band both comprise a left fixing band and a right fixing band, hook-and-loop fasteners are arranged on the left fixing bands and the right fixing bands, the left side or the right side of the rectangular plate is provided with a third fixing band, the rectangular plate is provided with a fixing base, and the fixing base is provided with a catheter fixing plate, the catheter fixing plate is provided with a plurality of inserting grooves and at least one inserting strip. Theperipheral vein fixing compressor of the invention can be used to fix the elbow joint and maintain the puncture position, and the situation that a puncture needle is displaced to puncture the blood vessel is prevented; meanwhile, the peripheral vein fixing compressor can also be used to press the puncture position for rapid hemostasis, then the working efficiency is improved, which can provide help for relieving the increasing shortage of medical staff at the present stage.

The invention provides a photochemical virus inactivation device loaded with plasma exchange and its application equipment, including: an inducer mixing unit, which is used to mix the diseased plasma filtered out in the plasma exchange mode with the inducer, and mix the mixed with inducer The plasma of the agent is sent to the photochemical virus inactivation unit; the photochemical virus inactivation unit is used to irradiate the plasma with the inducer to complete the virus inactivation, and send the inactivated plasma to the inducer removal unit; The inducer removal unit is used to filter out the inducer remaining in the inactivated plasma, and the inducer-removed plasma is used for fluid replacement. The present invention combines the membrane type plasma separation method with the photochemical virus inactivation method for the first time, and can continuously inactivate the plasma virus during the extracorporeal circulation of the blood.

A person who is used in the field of medicine-Preparation of mouse cell fusion maternal-fetal blood group incompatibility therapy hybrid strain, characterized by, Using erythropoietin as inducer, ''O'' type human bone marrow cell positive for Rh were cultured, to increase the number of directionally developing erythroid cells, Then the cultured human bone marrow cells were fused with murine myeloma cells to form hybridized cells, Erythropoietin was use to induce that directional differentiation of the hybridized cell, hybrid cell clones were screened by HAT. The hybridization strains of Rh positive cells which can be expanded indefinitely in vitro were screened by Rh antibody, As that adsorbent aft industrialized amplification. A low-cost and safe method for that treatment of maternal-fetal blood group incompatibility hemolytic disease without plasma exchange solution without remove plasma and its beneficial ingredients is create by absorbing pathogenic Rh antibody in peripheral plasmaof pregnant women with maternal-fetal blood group incompatibility through an in vitro adsorption device which is formed by an adsorber and a blood separator.

The invention discloses a collection device for plasma exchange. The collection device for plasma exchange comprises a first box body and a liquid outlet pipe, wherein the middle of the lower portionof the first box body is fixedly connected with the liquid outlet pipe, and heating devices are installed on the left side and the right side of the first box body. According to the collection devicefor plasma exchange, through mutual cooperation of the first box body, a stirring rod, a second transverse plate, a fourth bevel gear, a third bevel gear and other structures, plasma can be stirred through the stirring rod, so that the plasma is prevented from being solidified; through mutual cooperation of a motor, a first bevel gear, a second bevel gear, a threaded rod, a fluted disc, a gear rodand other structures, the threaded rod can be driven by the first motor to rotate, so that a stirring device works and the use performance is improved; and through mutual cooperation of an L-shaped plate, a second box body, the first box body, a heating plate and other structures, exchange liquid can be directly heated in the first box body through the heating plate, so that the operation time isshortened.

The invention discloses a plasma exchange device for treating microvascular diseases, and relates to the technical field of hematology department treatment, the plasma exchange device comprises a base, the base is provided with a tube groove for accommodating an extraction tube and an input tube, the base is provided with two groups of sliding grooves communicated with the tube groove, a pressing rod is accommodated in the sliding grooves and can extend into the tube groove, and the center of the pressing rod is provided with a rotatable disc driving block; the disc driving block is provided with two special-shaped combined grooves, the two special-shaped combined grooves are in central symmetry about the circle center of the disc driving block, the two special-shaped combined grooves are formed by combining straight kidney-shaped holes and arc-shaped kidney-shaped holes, the pressing rod is provided with a first cylinder stored in the special-shaped combined grooves, and a second spring is arranged on one side of the pressing rod. The driving assembly is arranged on the base and used for alternately driving the two sets of pressing rods to move in the axial direction, the special-shaped combined grooves are formed in the disc driving block to limit the pressing rods, when the pressing rods are driven to move in the axial direction at the same time, the relative axis freedom degree of the pressing rods is reserved, various combined clamping control can be achieved, and the control precision is high.

The invention discloses an application of a plasma-free replacement liquid composition in preparation of a medicine for removing M protein of multiple myeloma. Plasma exchange treatment can be carriedout on a multiple myeloma case with the plasma-free replacement fluid. The plasma-free replacement liquid composition comprises three parts which are equal in quantity, are independently prepared andare separately used, wherein the three parts are respectively 0.9% normal saline, equilibrium liquid and 4% albumin normal saline, the equilibrium liquid is sodium lactate Ringer's liquid, and the preparation method of the 4% albumin normal saline comprises the step of adding 100ml of 20% albumin into 400ml of normal saline. Compared with the prior art, the blood sedimentation index, the renal function index and the blood high-viscosity state of a patient can be effectively improved compared with those before treatment, and the patient does not have serious adverse reaction after treatment. The application of the plasma-free replacement liquid taking albumin as the main component remarkably reduces the dosage of fresh frozen plasma, and the plasma-free replacement liquid composition has clinical popularization value.

The invention relates to the technical field of plasma exchange, in particular to an adsorption, filtration and purification system for plasma exchange treatment, which is characterized in that a liquid inlet of a first-stage plasma separator is connected with a first conveying pipeline, and a first liquid outlet of the first-stage plasma separator is connected with a liquid inlet of a second-stage plasma separator through a second conveying pipeline; a first liquid outlet of the plasma secondary separator is connected with a liquid inlet of the plasma adsorber through a third conveying pipeline; the primary plasma separator separates blood into blood cells and plasma, the plasma enters the secondary plasma separator to be divided into plasma containing pathogenic factors and plasma without pathogenic factors, the plasma containing the pathogenic factors enters the plasma adsorber and the blood filter, and the plasma is adsorbed by the plasma adsorber and filtered and purified by the blood filter to obtain purified plasma; the adsorption, filtration and purification system for plasma exchange treatment completes separation of blood, purification of plasma containing pathogenic factors and collection of blood cells, plasma without pathogenic factors and purified plasma.

The invention discloses a bioartificial liver based on human iPSCs-induced hepatocytes and a multilayer porous bioreactor. Plasma separation column, first pressure monitor and heater, cell reactor/plasma component exchange double cycle part including plasma input peristaltic pump connected to plasma outlet in sequence and semi-permeable membrane exchange column in special incubator at 37°C, plasma exchange Peristaltic pump, red blood cell pool, membrane lung, multi-layer porous bioreactor, second and third pressure monitors, the outlet of the third pressure monitor and the outlet of blood cells are connected to the inlet of the first pressure monitor together, and then connected in sequence Heater and blood output tube. The present invention can maintain the temperature and oxygen supply required by the cells through the cooperation of the two circulation parts, improve the liquid exchange efficiency and biocompatibility at the same time, meet the clinical needs, and reduce the risk of heterogeneous virus infection and immune response risk.

The invention discloses an application of N-acetylcysteine in preparation of a medicine for treating hematopoietic stem cell transplantation related thrombotic microvascular disease, and also discloses a medicine for treating hematopoietic stem cell transplantation related thrombotic microvascular disease. Compared with an existing conventional scheme for treating the hematopoietic stem cell transplantation related thrombotic microvascular disease, the N-acetylcysteine is definite in curative effect, the effect of the N-acetylcysteine on patients with the hematopoietic stem cell transplantation related thrombotic microvascular disease is obviously superior to that of an existing treatment means, and another effective treatment way is provided for the patients. In addition, in the treatment process of N-acetylcysteine, conventional means such as plasma exchange and the like can be cooperated for joint treatment.