Application of N-acetylcysteine in preparation of medicine for treating hematopoietic stem cell transplantation related thrombotic microangiopathy

A technology of acetylcysteine ​​and hematopoietic stem cells, applied in the direction of extracellular fluid diseases, cardiovascular system diseases, blood diseases, etc., to achieve definite curative effect

Pending Publication Date: 2022-03-22
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the application of thrombotic micro

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  • Application of N-acetylcysteine in preparation of medicine for treating hematopoietic stem cell transplantation related thrombotic microangiopathy
  • Application of N-acetylcysteine in preparation of medicine for treating hematopoietic stem cell transplantation related thrombotic microangiopathy
  • Application of N-acetylcysteine in preparation of medicine for treating hematopoietic stem cell transplantation related thrombotic microangiopathy

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Embodiment 1

[0019] Embodiment 1: clinical case

[0020] The First Affiliated Hospital of Soochow University carried out a prospective randomized clinical trial. A total of 140 patients who underwent allogeneic hematopoietic stem cell transplantation were enrolled, of which 66 patients received NAC prophylactically from 9 days before the transplantation to 30 days after the transplantation, and 74 patients in the control group used it. amount of placebo. The incidence of TA-TMA was 9.1% (95% CI, 0.02-0.162) in the NAC group and 23% (95% CI, 0.132-0.328) in the control group, with a ratio ratio (RR) of 0.34 (95% CI, 0.123-0.911; P=0.039), thus indicating that NAC can significantly prevent the occurrence of TA-TMA. The 2-year OS rates of the NAC group and the control group were 75.4% (95%CI, 2.865-7.353) and 63.0% (95%CI, 0.508-0.735), respectively, and the HR was 0.622 (95%CI, 0.334-1.155; P= 0.132).

[0021] Activity was assessed in 66 patients from the NAC cohort and 74 patients from t...

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Abstract

The invention discloses an application of N-acetylcysteine in preparation of a medicine for treating hematopoietic stem cell transplantation related thrombotic microvascular disease, and also discloses a medicine for treating hematopoietic stem cell transplantation related thrombotic microvascular disease. Compared with an existing conventional scheme for treating the hematopoietic stem cell transplantation related thrombotic microvascular disease, the N-acetylcysteine is definite in curative effect, the effect of the N-acetylcysteine on patients with the hematopoietic stem cell transplantation related thrombotic microvascular disease is obviously superior to that of an existing treatment means, and another effective treatment way is provided for the patients. In addition, in the treatment process of N-acetylcysteine, conventional means such as plasma exchange and the like can be cooperated for joint treatment.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and specifically relates to the application of N-acetylcysteine ​​in the preparation of medicines for treating thrombotic microangiopathy related to hematopoietic stem cell transplantation. Background technique [0002] N-acetylcysteine ​​(NAC), is an organic compound with the molecular formula C 5 h 9 NO 3 S, white crystalline powder, has a garlic-like odor, sour taste, and hygroscopicity. As a medicine, it is suitable for dyspnea caused by a large amount of sticky sputum, such as difficulty in expectoration after surgery, acute and chronic bronchitis, bronchiectasis, tuberculosis, pneumonia, emphysema, etc. Phlegm blocking the trachea, etc. [0003] Hematopoietic stem cell transplantation-associated thrombotic microangiopathy is a syndrome of multi-organ damage caused by thrombosis in microvessels. Clinically, microvascular hemolytic anemia (with red blood cell fragments) and ...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P7/02A61P9/14A61P43/00
CPCA61K31/198A61P7/02A61P9/14A61P43/00
Inventor 韩悦吴德沛戚嘉乾何雪峰唐雅琼周萌蔡成森
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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