Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of N-acetylcysteine in preparation of medicine for treating hematopoietic stem cell transplantation related thrombotic microangiopathy

A technology of acetylcysteine ​​and hematopoietic stem cells, applied in the direction of extracellular fluid diseases, cardiovascular system diseases, blood diseases, etc., to achieve definite curative effect

Pending Publication Date: 2022-03-22
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the application of thrombotic microangiopathy associated with hematopoietic stem cell transplantation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of N-acetylcysteine in preparation of medicine for treating hematopoietic stem cell transplantation related thrombotic microangiopathy
  • Application of N-acetylcysteine in preparation of medicine for treating hematopoietic stem cell transplantation related thrombotic microangiopathy
  • Application of N-acetylcysteine in preparation of medicine for treating hematopoietic stem cell transplantation related thrombotic microangiopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: clinical case

[0020] The First Affiliated Hospital of Soochow University carried out a prospective randomized clinical trial. A total of 140 patients who underwent allogeneic hematopoietic stem cell transplantation were enrolled, of which 66 patients received NAC prophylactically from 9 days before the transplantation to 30 days after the transplantation, and 74 patients in the control group used it. amount of placebo. The incidence of TA-TMA was 9.1% (95% CI, 0.02-0.162) in the NAC group and 23% (95% CI, 0.132-0.328) in the control group, with a ratio ratio (RR) of 0.34 (95% CI, 0.123-0.911; P=0.039), thus indicating that NAC can significantly prevent the occurrence of TA-TMA. The 2-year OS rates of the NAC group and the control group were 75.4% (95%CI, 2.865-7.353) and 63.0% (95%CI, 0.508-0.735), respectively, and the HR was 0.622 (95%CI, 0.334-1.155; P= 0.132).

[0021] Activity was assessed in 66 patients from the NAC cohort and 74 patients from t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of N-acetylcysteine in preparation of a medicine for treating hematopoietic stem cell transplantation related thrombotic microvascular disease, and also discloses a medicine for treating hematopoietic stem cell transplantation related thrombotic microvascular disease. Compared with an existing conventional scheme for treating the hematopoietic stem cell transplantation related thrombotic microvascular disease, the N-acetylcysteine is definite in curative effect, the effect of the N-acetylcysteine on patients with the hematopoietic stem cell transplantation related thrombotic microvascular disease is obviously superior to that of an existing treatment means, and another effective treatment way is provided for the patients. In addition, in the treatment process of N-acetylcysteine, conventional means such as plasma exchange and the like can be cooperated for joint treatment.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and specifically relates to the application of N-acetylcysteine ​​in the preparation of medicines for treating thrombotic microangiopathy related to hematopoietic stem cell transplantation. Background technique [0002] N-acetylcysteine ​​(NAC), is an organic compound with the molecular formula C 5 h 9 NO 3 S, white crystalline powder, has a garlic-like odor, sour taste, and hygroscopicity. As a medicine, it is suitable for dyspnea caused by a large amount of sticky sputum, such as difficulty in expectoration after surgery, acute and chronic bronchitis, bronchiectasis, tuberculosis, pneumonia, emphysema, etc. Phlegm blocking the trachea, etc. [0003] Hematopoietic stem cell transplantation-associated thrombotic microangiopathy is a syndrome of multi-organ damage caused by thrombosis in microvessels. Clinically, microvascular hemolytic anemia (with red blood cell fragments) and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/198A61P7/02A61P9/14A61P43/00
CPCA61K31/198A61P7/02A61P9/14A61P43/00
Inventor 韩悦吴德沛戚嘉乾何雪峰唐雅琼周萌蔡成森
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com