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37results about How to "Reduced dosage requirements" patented technology

2-substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists

A compound of the formula:or a pharmaceutically acceptable salt thereof, wherein R is unsubstituted, mono-, di- or tri-substituted (C3-C11)cycloalkyl or (C3-C11)cycloalkenyl or the like, A is unsubstituted (C1-C7)alkyl or (C2-C5 )alkenyl, or unsubstituted, mono-, di- or tri-substituted aryl, or aromatic-heterocyclic or the like, Y is hydrogen, halo, amino or mercapto, or unsubstituted, mono-, di- or tri- substituted (C1-C10)alkyl-M-, (C3-C7)cycloalkyl-M-, (C2-C6)alkenyl-M-, (C1-C4)alkyl-NH-((C1-C4)alkyl)-M-, di(C1-C4)alkyl-N-((C1-C4)alkyl)-M-, aryl-M-, aromatic or non-aromatic heterocyclic-M-, aryl-(C1-C5)alkyl-M- or aromatic non-aromatic heterocyclic-(C1-C5)alkyl-M-, wherein M is a covalent bond O, S, NH or the like, or the like; Z1, Z2, Z3 and Z4 are hydrogen or the like, has ORL1-receptor agonist activity, and are useful as analgesics or the like in mammalian subjects.
Owner:PFIZER PHAMACEUTICALS INC

N-substituted spiropiperidine compounds as ligands for ORL-1 receptor

A compound of the formula: or a pharmaceutically acceptable salt, ester or ether thereof, wherein R1 through R12 are independently hydrogen or the like; X1 and X2 are independently CH2 or the like; R13 is hydrogen or the like; or R12 and R13 taken together with three ring atoms of the quinoline ring separating said substituents form a heterocyclic ring; R14 and R15 are hydrogen or the like or these groups taken together form oxo; and the dotted line represents a single or double bond. These compounds are ligands for ORL-1 receptor and especially are antagonists for said receptor.
Owner:PFIZER INC

2-benzimidazolylamine compounds as ORL-1-receptor agonists

A compound of the formula:or a pharmaceutically acceptable salt thereof, whereinR1 and R2 are independently selected from hydrogen, halo, hydroxy, (C1-C4)alkyl, halo (C1-C4)alkyl and the like; R3 and R4 are independently selected from hydrogen, halo(C1-C10)alkyl, optionally substituted (C1-C6)alkyl and the like, or R3 and R4, together with the nitrogen atom to which they are attached, form an optionally substituted fully saturated, partially saturated or fully unsaturated heterocyclic ring; and R5 is (C4-C11)cycloalkyl and the like, has ORL1-receptor agonist activity, and are useful as analgesics or the like in mammalian subjects.
Owner:PFIZER PHAMACEUTICALS INC

Pyrrolopyre compounds useful in treatment of cancer

The invention relates to compounds of the formula 1 [0001]or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein X, L, R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.
Owner:PFIZER INC

Plasma exchanging adsorption filtration purification system provided with plasma storage bag and application method of purification system

ActiveCN103263704AEnables multiple flow-through purification cyclesRealize self-reuseHaemofiltrationDialysis systemsMiddle moleculeFiltration
The invention discloses a plasma exchanging adsorption filtration purification system provided with a plasma storage bag and an application method of the purification system. The method includes two steps of plasma components separation returning cycle and high-speed plasma purification regeneration cycle. Plasma components are separated by a selective membrane plasma separator; flow speed difference between a plasma separation cycle and a plasma purification circle is set by the specific plasma storage bag; high-speed plasma adsorption filtration purification treatment is performed by a high-throughput filter and an active carbon-resin absorptive device in a purification circle; and plasma subjected to cycle treatment for multiple times can be exchanged back to a human body through the separation returning circle. By the aid of the purification system and the application method thereof, autologous plasma waste generated in a plasma exchanging purification process can be purified continuously and effectively, and plasma consumption is reduced. The high-throughput filter and an adsorption column are connected in series to purify the plasma; load on a subsequent adsorber is reduced; and varied inflammatory factors, macromolecular toxins and the like combined by micromolecules, middle molecules and proteins which are generated from hepatic failure are eliminated as well, so that the purification efficiency of the whole system is greatly improved.
Owner:ZHEJIANG UNIV +1

2-(Pyridin-2-ylamino)-pyrido [2,3-D]pyrimidin-7-ones

The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4).
Owner:WARNER-LAMBERT CO

Small molecule inhibitors of necrosis

The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2 INHIBITORS

The present invention provides novel 3,4-disubstituted-1H-pyrrolo[2,3-b]pyridine derivatives and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazine derivatives of Formula I, and the pharmaceutically acceptable salts thereofwherein R1, R2, R3, R4 and X are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
Owner:PFIZER INC

Polypropylene halogen-free flame-retardant material and preparation method thereof

InactiveCN112457575AImprove graft modification efficiencyAvoid stickingElastomerAluminium hydroxide
The invention relates to the technical field of polypropylene, in particular to a polypropylene halogen-free flame-retardant material and a preparation method thereof, and the polypropylene halogen-free flame-retardant material comprises the following raw materials: polypropylene, a halogen-free flame retardant, a toughening agent, a compatilizer, a nucleating agent and an antioxidant. According to the toughening agent disclosed by the invention, the prepared polypropylene material has a hierarchical structure of nano silicon dioxide-polyurethane-nano aluminum hydroxide-polypropylene, nano silicon dioxide and nano aluminum hydroxide are used as rigid bodies, so that stress concentration points are more easily generated, and crazes are formed at the periphery to absorb impact energy; the polyurethane serving as an interlayer can better absorb impact energy in two directions and is favorable for stopping crazing, so that the impact resistance of the polypropylene is greatly improved; besides, polyurethane is used as an elastomer, so that the elongation at break of polypropylene can be improved, and nano aluminum hydroxide is used as a synergistic flame retardant, so that the dosage requirement of the halogen-free flame retardant can be reduced, the mechanical property of polypropylene is improved, and the V0-grade flame retardant property is maintained.
Owner:东莞市鑫塑源塑胶科技有限公司

Preparation method of Mn<4+>-activated fluoride fluorescent powder

The invention provides a preparation method of Mn<4+>-activated fluoride fluorescent powder. The preparation method provided by the invention does not need to form a saturated solution of A2MF6, so that the requirement of the use amount of raw materials is greatly reduced; in the preparation process, the target product can be synthesized at room temperature and is convenient to synthesize; a precipitating agent is added, so that the preparation is more convenient, the operation is simpler, the synthetic steps are simplified, and the prepared fluorescent powder has better optical properties; the fluoride fluorescent powder can be well excited by ultraviolet light to blue light, especially the blue light, and has strong red light emission, wherein the red light emission peak is in the wavelength range from 600 to 650 nm; the method has the advantages of a simple preparation process and short consumed time; and the prepared material has a high luminescence quantum yield and is suitable for industrial large-scale preparation.
Owner:FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI

Feed additive for reducing excretion quantity of nitrogen and phosphorus in animal waste

The invention provides a feed additive for reducing the excretion quantity of nitrogen and phosphorus in animal waste, and application of the feed additive. On the basis of low protein daily ration, histidine, beta-alanine and a complex enzyme preparation are added, so that the excretion quantity and the excretion rate of nitrogen and phosphorus in animal waste can be reduced. The feed additive for reducing the excretion quantity of nitrogen and phosphorus in animal waste is low in cost and environmentally friendly; furthermore, after the feed additive is adopted, the balance of amino acid in the daily ration is maintained, and the nutritional requirement of growth and development of animals can be met, so that the feed additive has high popularization and application values.
Owner:天蓬集团有限公司 +2

Online pH measurement device and method of high-temperature strong-washing neutralization solution

The invention provides an online pH measurement device of a high-temperature strong-washing neutralization solution. The device comprises a measuring sampling tube, a pH meter, a pneumatic telescopicprotecting sleeve for fixing the pH meter and a cleaning control device, wherein a water inlet, a water outlet, a testing hole and a drain outlet are formed in the measuring sampling tube; the pH meter is fixedly arranged on a push rod of the pneumatic telescopic protecting sleeve; the pneumatic telescopic protecting sleeve is arranged at the testing hole and detachably connected with the measuring sampling tube, and a washing water inlet and a washing water outlet are formed in the pneumatic telescopic protecting sleeve; the washing water inlet is connected with clear water through a water pipe, a washing water electromagnetic valve is arranged at the washing water inlet, and the washing water outlet is connected with a trench through a water pipe; the cleaning control device comprises aDCS control system, and the DCS control system is provided with a main relay and a cleaning relay. Online measurement of the high-temperature strong-washing neutralization solution is realized, and the device is simple in structure, capable of performing automatic cleaning, convenient to operate, long in online testing time, stable in operation and accurate in measurement result, can reduce blocking and provides convenience for environment-friendly drainage.
Owner:GUANGDONG NANFANG SODA ASH IND

Water-based cleaning agent for structural member of laser amplification device in strong irradiation working environment and cleaning method of water-based cleaning agent

The invention provides a water-based cleaning agent for a laser amplification device structural member in an irradiation working environment and a cleaning method of the water-based cleaning agent, and belongs to the technical field of metal part cleaning, the water-based cleaning agent is prepared from the following raw materials by weight: 2 parts of a DBE solvent, 2 parts of 3-methoxy-3-methyl-1-butanol, 5 parts of a nonionic surfactant, 1 part of an emulsifier, and 10 parts of deionized water. Compared with traditional ultrasonic cleaning, the failure time of the ultrasonic cleaning fluid is several times that of traditional pure ultrasonic water-based cleaning fluid, and a large amount of water resources can be saved through the scheme. And compared with traditional ultrasonic cleaning, the working efficiency of the ultrasonic cleaning device is also higher.
Owner:SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI

Plasma exchange absorption filter purifying system with square plasma storage tank

InactiveCN103263705AEnables multiple flow-through purification cyclesRealize self-reuseHaemofiltrationDialysis systemsActivated carbonAbsorption filter
The invention discloses a plasma exchange absorption filter purifying system with a square plasma storage tank. The plasma exchange absorption filter purifying system comprises a fractional plasma separation feedback circulating part and a plasma purification regeneration circulating part. A selective membrane plasma separator is used to separate fractional plasma, flow rate difference of plasma separation circulating and plasma purification circulating is built by the special square plasma storage tank, two-stage purification is arranged before and after the square plasma storage tank during purification circulating, primary bilirubin absorption columns are arranged before the square plasma storage tank, a high-pass filter and an activated carbon absorber are arranged after the square plasma storage tank for absorption filter purification, and plasma after multiple circulations is fed back to human bodies by means of separation feedback circulation exchange. By the system, autologous waste plasma generated during plasma exchange purification can be purified continuously, plasma use is reduced. By the two-stage absorption filter system, small molecules, medium-sized molecules, inflammatory factor combined with proteins and large-molecule toxin and the like which are generated by liver failure can be eliminated, and system purification efficiency can be increased.
Owner:ZHEJIANG UNIV +1

Cyclic substituted imidazo[4,5-c]quinoline derivatives

The present invention provides novel cyclic substituted imidazo[4,5-c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof, wherein R1, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
Owner:PFIZER INC

Method for increasing reducing sugar content of straws

InactiveCN106566854ALoose structureStrengthen the destructive powerFermentationCellulaseFilter paper
The invention discloses a method for increasing reducing sugar content of straws. The method comprises the following steps carried out in sequence: 1, performing electron beam irradiation on the straws; 2, putting the straws into a hydrochloric acid solution with the volume concentration of 30-35% to perform acidification for 12-24 hours, and performing stewing for 2-6 hours at a starting temperature of 50 DEG C and a heating rate of 0.5 DEG C / min; and 3, adjusting the pH value and temperature of a stewed straw solution to 4.9 and 60 DEG C or below respectively, adding cellulase to the straw solution according to a mass ratio of the cellulase to the straws of 6-9 : 1,000, and performing enzymolysis for 5-24 hours, wherein the filter paper enzyme activity of the cellulase is 1,400-1,500 FPU / g. According to the method, the tissue structures of the straws are greatly changed and destroyed; the utilization amount of the cellulase is reduced; the production cost is reduced; the reducing sugar content in the straws is greatly increased after processing; and the method is suitable for industrial production.
Owner:INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI

a mn 4+ Preparation method of ion-activated fluoride phosphor

The invention provides a preparation method of Mn<4+>-activated fluoride fluorescent powder. The preparation method provided by the invention does not need to form a saturated solution of A2MF6, so that the requirement of the use amount of raw materials is greatly reduced; in the preparation process, the target product can be synthesized at room temperature and is convenient to synthesize; a precipitating agent is added, so that the preparation is more convenient, the operation is simpler, the synthetic steps are simplified, and the prepared fluorescent powder has better optical properties; the fluoride fluorescent powder can be well excited by ultraviolet light to blue light, especially the blue light, and has strong red light emission, wherein the red light emission peak is in the wavelength range from 600 to 650 nm; the method has the advantages of a simple preparation process and short consumed time; and the prepared material has a high luminescence quantum yield and is suitable for industrial large-scale preparation.
Owner:FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI

Plasma Exchange Adsorption Filtration Purification System Equipped with Plasma Storage Bag

ActiveCN103263704BEnables multiple flow-through purification cyclesRealize self-reuseHaemofiltrationDialysis systemsMiddle moleculeFiltration
The invention discloses a plasma exchanging adsorption filtration purification system provided with a plasma storage bag and an application method of the purification system. The method includes two steps of plasma components separation returning cycle and high-speed plasma purification regeneration cycle. Plasma components are separated by a selective membrane plasma separator; flow speed difference between a plasma separation cycle and a plasma purification circle is set by the specific plasma storage bag; high-speed plasma adsorption filtration purification treatment is performed by a high-throughput filter and an active carbon-resin absorptive device in a purification circle; and plasma subjected to cycle treatment for multiple times can be exchanged back to a human body through the separation returning circle. By the aid of the purification system and the application method thereof, autologous plasma waste generated in a plasma exchanging purification process can be purified continuously and effectively, and plasma consumption is reduced. The high-throughput filter and an adsorption column are connected in series to purify the plasma; load on a subsequent adsorber is reduced; and varied inflammatory factors, macromolecular toxins and the like combined by micromolecules, middle molecules and proteins which are generated from hepatic failure are eliminated as well, so that the purification efficiency of the whole system is greatly improved.
Owner:ZHEJIANG UNIV +1

A device and method for online measurement of pH of neutralizing liquid with high temperature and strong scour

The invention provides an on-line pH measuring device for high-temperature strong scouring neutralizing liquid, comprising: a measuring sampling cylinder, a pH meter, a pneumatic telescopic protective cover for fixing the pH meter, and a cleaning control device; the measuring and sampling cylinder is provided with a water inlet and a water outlet , test hole, cut-off hole, sewage outlet; the pH meter is fixed on the push rod of the pneumatic telescopic protective cover; There is a washing water inlet and a washing water outlet; the washing water inlet is connected to clean water through a water pipe, the washing water inlet is provided with a washing water solenoid valve, and the washing water outlet is connected to the trench through a water pipe; the cleaning control device includes a DCS control system, The DCS control system is equipped with a main control relay and a cleaning relay. The invention realizes on-line measurement of high-temperature strong scouring neutralizing liquid, has simple structure, automatic cleaning, convenient operation, less clogging, long on-line test time, stable operation, accurate measurement results, and provides convenience for environmental protection and sewage discharge.
Owner:GUANGDONG NANFANG SODA ASH IND
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