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A kind of cefdinir composition granule and preparation method thereof
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A technology of cefdinir and composition, which is applied in the field of pharmaceutical preparations, can solve the problems of cefdinir stability and low dissolution rate, and achieve the effects of being conducive to safe use and long-term storage, improving stability, and increasing dissolution rate
Active Publication Date: 2015-07-29
SHANDONG LUOXIN PHARMA GRP CO LTD +2
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For example, patent CN201010176154.8 discloses a suspension granule of cephalosporins and its preparation method. agent, spices, wherein embodiment 4 specifically discloses a technical scheme of cefdinir suspension granules, although it can bring certain improvement to the quality of cefdinir preparations, too many component selections also become a problem for cefdinir Factors Influencing the Stability and Dissolution of Diniline
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Embodiment 1
[0023] Embodiment 1: preparation cefdinir composition granule of the present invention
[0024]
[0025] Pass cefdinir through a 120-mesh sieve for later use, and crush sucrose through an 80-mesh sieve for later use; weigh cefdinir, pregelatinized starch, sodium hydroxypropyl cellulose, and sucrose and mix thoroughly, and use 50% ethanol to make a soft material, 20 mesh Wet granulation, the granules are blast-dried at about 65°C, the dry granules are granulated with 16 mesh, sieved with 80 mesh, the intermediate product is tested, and the product is ready to pack.
Embodiment 2
[0026] Embodiment 2: preparation cefdinir composition granule of the present invention
[0027]
[0028] Pass cefdinir through a 120-mesh sieve for later use, and crush sucrose through an 80-mesh sieve for later use; weigh cefdinir, pregelatinized starch, sodium hydroxypropyl cellulose, and sucrose and mix thoroughly, and use 50% ethanol to make a soft material, 20 mesh Wet granulation, the granules are blast-dried at about 65°C, the dry granules are granulated with 16 mesh, sieved with 80 mesh, the intermediate product is tested, and the product is ready to pack.
Embodiment 3
[0029] Embodiment 3: preparation cefdinir composition granule of the present invention
[0030]
[0031] Pass cefdinir through a 120-mesh sieve for later use, and crush sucrose through an 80-mesh sieve for later use; weigh cefdinir, pregelatinized starch, sodium hydroxypropyl cellulose, and sucrose and mix thoroughly, and use 50% ethanol to make a soft material, 20 mesh Wet granulation, the granules are blast-dried at about 65°C, the dry granules are granulated with 16 mesh, sieved with 80 mesh, the intermediate product is tested, and the product is ready to pack.
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Abstract
The invention relates to the medicinal preparation field, and concretely discloses a cefdinir composition granule and a preparation method thereof. The effective components of the cefdinir composition granule comprise cefdinir, pregelatinized starch, 50% ethanol, sodium hydroxy propyl cellulose and sucrose. In the invention, cefdinir, pregelatinized starch, 50% ethanol, sodium hydroxy propyl cellulose and sucrose are preferably selected as the effective components of the cefdinir composition granule, the mutual synergistic effect of the effective components increases the stability and the dissolution of cefdinir, and the mouthfeel is better than that of present products, so the medicine use compliance of patients is improved, and it is in favor of the safe use and long-term storage of clinic medicines.
Description
technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefdinir composition granule and a preparation method thereof. Background technique [0002] Cefdinir, the English name is Cefdinir Capsules, the chemical name is (6R, 7R)-7-[[(2-amino-4-thiazolyl)-(oximino)acetyl]amino]-3-vinyl-8 -Oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, the chemical structure is as follows: [0003] [0004] Cefdinir belongs to the semi-synthetic, broad-spectrum oral third-generation cephalosporins, which produce antibacterial effects by inhibiting the synthesis of bacterial cell walls. This product has antibacterial activity against Gram-positive bacteria and negative bacteria, and is stable to most β-lactamases, so many microorganisms resistant to penicillins and cephalosporins are sensitive to this product. Clinically used for the treatment of tonsillitis, sinusitis, otitis media, acute bronchitis, pneumonia, abdominal cavi...
Claims
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