Method, using response surface methodology, for optimizing ultrasonic extraction technology of free anthraquinone from cassia seeds

A technology of free anthraquinone and extraction process, applied in organic chemistry, quinone separation/purification, etc., can solve the problems of unstable processing quality, low economic benefit, poor technical conditions, etc., and achieve accurate and reliable extraction conditions and high extraction rate. Effect

Inactive Publication Date: 2013-09-25
亳州市盛林中药饮片有限公司
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Problems solved by technology

[0003] However, at present, the technical conditions of my country's drug extraction and production enterprises are relatively poor, and the use of relatively old processes has not only caused a great waste of resources, but also caused environmental pollution, unstable processing quality and other factors, high production costs and low economic benefits.

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  • Method, using response surface methodology, for optimizing ultrasonic extraction technology of free anthraquinone from cassia seeds
  • Method, using response surface methodology, for optimizing ultrasonic extraction technology of free anthraquinone from cassia seeds
  • Method, using response surface methodology, for optimizing ultrasonic extraction technology of free anthraquinone from cassia seeds

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Embodiment 1

[0027] ① Determination of free anthraquinone:

[0028] Determination of the standard curve: Prepare 0.1 mg / mL l,8-dihydroxyanthraquinone standard solution with 0.5% magnesium acetate-methanol as solvent, accurately measure 0, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0 mL respectively, and set In a 10mL volumetric flask, add solvent to the volume, shake well, and measure its absorbance at a wavelength of 510nm. Use 0.5% magnesium acetate-methanol solution as a blank control, and the mass concentration of 1,8-dihydroxyanthraquinone is between 5 and The equation of the standard curve within the range of 30μg / mL is: Y = 0.3332X + 0.0294, R2 = 0.9954.

[0029] Determination of free anthraquinone: draw 2mL of each extract into a separatory funnel, add 3mL of water, shake vigorously, extract twice with 8mL and 7mL of chloroform, add 2mL of distilled water to wash, collect the chloroform solution, evaporate to dryness on a water bath, add 5mL of 0.5% Dissolve in magnesium acetate-methanol solution...

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Abstract

The invention discloses a method, using a response surface methodology, for optimizing ultrasonic extraction technology of free anthraquinone from cassia seeds. According to the method, cassia seeds are used as a raw material and ultrasonic technology is used to assist extraction of free anthraquinone. The volume fraction of ethanol, the ultrasonic extracting temperature and the ultrasonic extracting time are optimized by using the response surface methodology to obtain an optimum extraction technology for free anthraquinone. The extraction yield of free anthraquinone by using the technology is 28.32%. The extraction conditions are accurate and reliable, the extraction yield is high, and the extraction conditions have use value.

Description

technical field [0001] The invention mainly relates to a method for optimizing the ultrasonic extraction process, in particular to a method for optimizing the ultrasonic extraction process of cassia seed free anthraquinone by response surface method. Background technique [0002] Semen Cassiae is a traditional Chinese medicine in my country. It has the effects of clearing the liver, improving eyesight, moistening the intestines and laxative. It is used in a variety of prescription preparations for reducing fat and losing weight. At the same time, cassia seed can also be used as edible traditional Chinese medicine, and is a good raw material for health drinks. Anthraquinones are the main components in cassia seeds, and anthraquinones mainly include chrysophanol, emodin, rhein and so on. [0003] However, at present, the technical conditions of my country's drug extraction production enterprises are relatively poor, and the use of relatively old processes has not only caused a...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C50/18C07C46/10
Inventor 刘博
Owner 亳州市盛林中药饮片有限公司
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