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Application of Chukrasone B in medicine for treating hemorrhagic fever with renal syndrome

A technology for renal syndrome and hemorrhagic fever, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as uncertain effects, and achieve strong inhibitory activity of hemorrhagic fever with renal syndrome virus and highlight the essence The effect of sexuality

Inactive Publication Date: 2013-10-30
丁圣雨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiviral treatments such as ribavirin and interferon are often used clinically, but the effect is not yet certain

Method used

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  • Application of Chukrasone B in medicine for treating hemorrhagic fever with renal syndrome
  • Application of Chukrasone B in medicine for treating hemorrhagic fever with renal syndrome
  • Application of Chukrasone B in medicine for treating hemorrhagic fever with renal syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Preparation of Chukrasone B tablet, the compound involved in the present invention:

[0013] Take 20 grams of the compound Chukrasone B, add 180 grams of conventional excipients for preparing tablets, mix them, and prepare 1,000 tablets with a conventional tablet press.

Embodiment 2

[0014] Example 2: Preparation of the compound Chukrasone B capsule of the present invention:

[0015] Take 20 grams of the compound Chukrasone B, add 180 grams of conventional excipients for preparing capsules, such as 180 grams of starch, mix well, and encapsulate to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] In order to better understand the essence of the present invention, the experimental research results of Chukrasone B will be used to illustrate its application in the pharmaceutical field.

[0018] The specific experiment is as follows:

[0019] 1. Experimental study of Chukrasone B against hemorrhagic fever with renal syndrome virus

[0020] (1) In vitro inhibition experiment on hemorrhagic fever with renal syndrome virus

[0021] 1 material

[0022] (1) Virus strain: 76-118 strains of international standard hemorrhagic fever with renal syndrome virus, preserved by the Institute of Chinese Academy of Pre...

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Abstract

The invention discloses a new application of Chukrasone B in preparation of a medicine for treating hemorrhagic fever with renal syndrome. Experiment researches on inhibiting hemorrhagic fever with renal syndrome virus by the Chukrasone B in vitro and in vivo show that the Chukrasone B has a low toxic effect on cells, has an effect of killing the hemorrhagic fever with renal syndrome viruses directly and can obviously inhibit the viruses from increasing, and the Chukrasone B has an obvious effect of protecting gophers infected by the virus, thus postponing the disease time, prolonging the course of disease and lowering the death rate. Therefore, the Chukrasone B is an effective and safe medicine for treating hemorrhagic fever with renal syndrome.

Description

Technical field [0001] The present invention relates to the use of Chukrasone B, in particular to the use of Chukrasone B in the pharmaceutical field. Background technique [0002] There are 13 types of human viral hemorrhagic fever in the world. According to whether the disease has kidney damage, it can be divided into two categories: renal damage and no renal damage. In my country, it is mainly hemorrhagic fever with renal syndrome (HFRS), also known as epidemic hemorrhagic fever. Fever (EHF); known as Korean hemorrhagic fever (KHF) in North Korea; known as hemorrhagic nephritis (HNN) in the Soviet Union; due to the establishment of specific serological diagnosis and the resolution of the etiology, the World Health Organization unified the name as Renal Syndrome in 1982 Sign hemorrhagic fever. [0003] The disease is caused by the Korean hemorrhagic fever virus (or Hantavirus), a natural foci disease with rodents as the main source of infection; it can be transmitted through the r...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P31/14A61P13/12
Inventor 丁圣雨
Owner 丁圣雨
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