Method for preparing nano-silver-containing composite fibrous membrane capable of being used for medical dressings

A technology of composite fiber membrane and nano-silver, which is applied in the fields of spinning solution preparation, medical science, textiles and papermaking, etc., to achieve the effects of adjustable hydrophilicity and hydrophobicity, good biocompatibility and high water absorption rate

Inactive Publication Date: 2013-12-04
WUYI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation method of the PCL / PVP composite fiber membrane containing nano-silver has not yet been reported.

Method used

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  • Method for preparing nano-silver-containing composite fibrous membrane capable of being used for medical dressings
  • Method for preparing nano-silver-containing composite fibrous membrane capable of being used for medical dressings
  • Method for preparing nano-silver-containing composite fibrous membrane capable of being used for medical dressings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] a. Preparation of nano-silver colloid solution: Dissolve 0.4g silver nitrate in 1mL water; make 0.4g / mL silver nitrate aqueous solution; dissolve 1g PVP in 9mL DMF, wait until completely dissolved, and prepare reducing solution; In a water bath at 85°C, keep stirring the reducing solution, then slowly add the silver nitrate solution dropwise to the reducing solution, after the dropwise addition, continue stirring for 6 hours to complete the preparation of the silver colloid solution containing 0.0254 g / mL of nano-silver ;

[0032] b. Preparation of a solution of PCL: dissolve 3 g of PCL in methylene chloride (PCL to PVP mass ratio 100:0), stir until dissolved, and form a 9wt% PCL solution;

[0033] c. Preparation of spinning solution: Dilute the nano-silver colloid solution prepared in a twice, pipette the diluted nano-silver colloid 1.5mL and add it into the prepared 9wt% PCL solution, stir well, and obtain The mixed spinning solution of nano silver amount 0.64wt% (re...

Embodiment 2

[0037] a. Preparation of nano-silver colloid solution: Dissolve 0.4g silver nitrate in 1mL water; make 0.4g / mL silver nitrate aqueous solution; dissolve 1g PVP in 9mL DMF, wait until completely dissolved, and prepare reducing solution; In a water bath at 85°C, keep stirring the reducing solution, then slowly add the silver nitrate solution dropwise to the reducing solution, after the dropwise addition, continue stirring for 6 hours to complete the preparation of the silver colloid solution containing 0.0254 g / mL of nano-silver ;

[0038] b. Preparation of PCL / PVP blended solution: 2.7g PCL and 0.3g PVP were dissolved in dichloromethane (PCL and PVP mass ratio 90:10), after standing for a period of time, stirred evenly to form a concentration of 9wt% PCL / PVP blend solution.

[0039] c. Preparation of spinning solution: Dilute the nano-silver colloid solution prepared in a. twice, pipette the diluted nano-silver colloid 1.5mL into the prepared 9wt% PCL / PVP mixed solution, stir ...

Embodiment 3

[0043] a. Preparation of nano-silver colloid solution: Dissolve 0.4g silver nitrate in 1mL water; make 0.4g / mL silver nitrate aqueous solution; Reducing solution: Stir the reducing solution continuously in a water bath at 85°C, then slowly add the silver nitrate solution dropwise to the reducing solution, and continue stirring for 6 hours after the addition is complete, to complete the silver nano-silver containing 0.0254g / mL Preparation of glue solution.

[0044] b. Preparation of PCL / PVP blend solution: 2.4gPCL and 0.6gPVP are dissolved in dichloromethane (PCL and PVP mass ratio 80: 20), after standing for a period of time, stirring is evenly made into a concentration of 9wt% co- mixed solution.

[0045] c. Preparation of spinning solution: Dilute the nano-silver colloid solution prepared in a. twice, pipette the diluted nano-silver colloid 1.5mL into the prepared 9wt% PCL / PVP mixed solution, stir well, Make the mixed spinning solution that contains nano-silver amount 0.64...

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Abstract

The invention relates to a method for preparing a nano-silver-containing composite fibrous membrane capable of being used for medical dressings. The composite fibrous membrane comprises nano-silver-containing polycaprolactone (PCL) / polyvinylpyrrolidone (PVP), and is prepared on the basis of an electrostatic spinning method. The method includes: (1) using N,N-dimethylformamide (DMF) as a reducing agent, reducing silver nitrate in water bath at the temperature of 80-95 DEG C, and stirring continuously for 4-7 hours to obtain a nano-silver colloid solution; (2), mixing the PCL and the PVP according to a certain proportion, dissolving the mixture in cosolvent dichloromethane, and stirring uniformly to obtain a mixed solution; (3) diluting the nano-silver colloid solution by certain times, adding the diluent into the mixed solution, and stirring uniformly to obtain electrostatic spinning liquid; (4) performing electrostatic spinning on the electrostatic spinning liquid to obtain the nano-silver-containing PCL / PVP composite fibrous membrane. The fibrous membrane has the advantages of good biocompatibility, hydrophilia and hydrophobicity controllability, high water absorption and the like; the surface of the fibrous membrane contains nano-silver, so that the fibrous membrane has strong antibacterial action and is suitable for preparing the medical dressings.

Description

technical field [0001] The invention relates to a method for preparing a composite fiber film containing nano-silver for medical dressings, in particular to a method for preparing a polycaprolactone / polyvinylpyrrolidone composite fiber film containing nano-silver for medical dressings, belonging to medical dressings field. Background technique [0002] Medical dressings are an important medical textile used to cover and treat wounds to protect the human body. Their main functions are to control wound exudate, prevent the wound from being further damaged by the invasion of external microorganisms, and effectively promote wound healing at the same time. With the development of the economy, the population is aging, and the wounds of middle-aged and young people are increasing. The chronic wounds (bedsores, ulcers, etc.) and other difficult-to-heal wounds (such as diabetic foot ulcers, traumatic wounds, burns, The requirements for dressings for wounds, etc.) need to be improve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728D01D1/02A61L15/26A61L15/24A61L15/44
Inventor 贾永堂刘青青朱湘英董凤春黄钢
Owner WUYI UNIV
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