Multiparticulate l-menthol formulations and related methods

Abstract

The present invention provides an enteric-coated multiparticulate formulation using L-menthol as an active ingredient. In one embodiment, the multiparticulate formulation includes a plurality of microparticles with reduced release in the gastric environment and enhanced release in the neutral pH environment. The microparticles include a core with L-menthol as an active ingredient. The L-menthol supplied to the core is an L-menthol material having a purity of at least 80%. An enteric coating is applied over the core. The enteric coating is effective to release at least 80% of the L-menthol within about 2 hours in a substantially neutral pH environment. Other aspects of the invention include methods of making and using multiparticulate formulations.

Description

[0001] Cross References to Related Applications

[0002] This application claims priority to U.S. Provisional Patent Application No. 61 / 441,716, filed February 11, 2011, entitled "Multiparticulate Formulations and Related Methods," which is hereby incorporated by reference in its entirety, and which also claims Priority to U.S. Provisional Patent Application No. 61 / 486,523, entitled "Multiparticulate Formulations and Related Methods," filed May 16, 1999, the entire contents of which are hereby incorporated by reference. technical field

[0003] The present invention relates to multiparticulate formulations for the delivery of high purity L-menthol to the intestine, and in particular, to enteric coated high purity L-multiparticulate formulations and related methods. Background technique

[0004] For quite some time, essential oils have been used due to their biological activity. Today, some essential oils are used as medicines. For example, the plant peppermint or wild pepp...

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