Methods for Encapsulation of Active Substances in Droplets and Other Compartments

A droplet and liquid technology, applied in chemical instruments and methods, mixing methods, formulations of perfume preparations, etc., can solve the problems of reducing the usable storage life of products and increasing the possibility of payload

Inactive Publication Date: 2020-07-14
PROCTER & GAMBLE CO +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In formulated products containing high levels of surfactant as well as microparticles with oil-based payloads, the presence of surfactant tends to increase the likelihood of payload migration from the microparticle and reduce the usable shelf life of the product

Method used

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  • Methods for Encapsulation of Active Substances in Droplets and Other Compartments
  • Methods for Encapsulation of Active Substances in Droplets and Other Compartments
  • Methods for Encapsulation of Active Substances in Droplets and Other Compartments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] This example shows the encapsulation of an active substance embedded within a secondary compartment to achieve controlled release characteristics. In this example, fragrance is encapsulated as an exemplary embodiment. Fragrances are usually mixtures of polar and non-polar components (eg fragrance essential oils or aroma compounds). Therefore, encapsulation of fragrances in polymeric shells dispersed in the aqueous phase can be challenging because of their significant sensitivity in a wide range of solvents and even in most shell materials (monomers). Solubility.

[0162] This example shows a method of encapsulating a pre-emulsified fragrance in a hydrophobic polymer shell, achieving high loading efficiencies, eg, over 50%. In this particular example, in order to first form a double emulsion (water-in-oil-in-water), three phases were injected into the microcapillary device: 10% PVA (polyvinyl alcohol) in the water phase as the continuous phase, with a photoinitiator ( ...

Embodiment 2

[0166] In this embodiment, the antioxidant is encapsulated as another exemplary embodiment. see figure 2 .

[0167] A monomer solution of THBQ was prepared. An antioxidant (tert-butylhydroquinone, TBHQ, 600 mg) was dissolved in EtOH (1 mL) in a glass vial. To a vial containing a hydrophobic monomer (pentaerythritol triacrylate, PETA, 3 g) and a photoinitiator (2-hydroxy-2-methylpropiophenone, HMP, 30 mg), a solution of TBHQ in EtOH was added. The solution (2 g) was placed under vacuum for 6 hours to remove EtOH and form a clear viscous fluid of monomer in which TBHQ was dissolved.

[0168] Prepare a water-in-oil emulsion. To the resulting solution was added 8 mL of PVA in water (10% by weight), and the resulting mixture was placed on a vortex for 1 minute. After initial mixing, the cloudy emulsion was subjected to focused sonication for 15 minutes in an ice bath (40% power, 5 sec sonication, 2 sec intervals).

[0169] Synthesis of secondary particle dispersions in water...

Embodiment 3

[0172] Example 3 Preparation of α-pinene-encapsulated ETPTA microcapsules with and without hydrogel network continuous phase in microcapsules. The microcapsules were rinsed with DI water to remove the continuous aqueous phase carrying the microcapsules. After removing the surrounding water, large differences in microcapsule morphology were observed over time. For the control microcapsules, the water phase of the fragrance emulsion was replaced by air as the water evaporated. For PEG hydrogel microcapsules, no significant difference was observed. Upon rupture, a uniform hydrogel network in the PEG hydrogel microcapsules was observed. Such as Figure 5 As shown in , the control microcapsules had a dispersed phase retention of less than about 40% w / w after 5 days, while the hydrogel continuous phase microcapsules had a dispersed phase retention of about 50% w / w.

[0173] The various embodiments described above can be used as part of a range of consumer product formulations. ...

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Abstract

The present invention relates generally to microparticles, and more particularly to systems and methods for encapsulation within microparticles. In one aspect, the invention relates generally to microparticles comprising an entity therein, wherein the entity comprises an agent releasable from the microparticle, eg, by diffusion. In some cases, the reagents can be released from the microparticles without destroying the microparticles. The entities can be, for example, polymer particles, hydrogel particles, fluid droplets, and the like. The entities may be contained within a fluid, which in turn is encapsulated within the microparticles. The agent can be released from the entity into the fluid and then from the fluid through the microparticles. In such a manner, the release of reagents from microparticles can be controlled, eg, over relatively long timescales. Other embodiments of the invention relate generally to methods of making such microparticles, methods of using such microparticles, microfluidic devices for making such microparticles, and the like.

Description

technical field [0001] The present invention relates generally to microparticles, and more particularly to systems and methods for encapsulation within microparticles. Background technique [0002] Microparticles such as microcapsules have great application potential in fields involving the encapsulation, delivery, and release of agents such as agriculture, health care, cosmetics and detergents, construction chemicals, and food and beverages . Various physical and chemical methods, including spray drying, coextrusion, interfacial polymerization, and complex coacervation, have been used for high-throughput microparticle preparation. For example, using various microfluidic techniques, various reagents have been encapsulated in emulsions which are then solidified to form microsolids or other types of particles by, for example, interfacial condensation, freezing or polymerization. However, there is still a need to improve particle technology. [0003] In formulated products c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/06B01F5/04B01F13/10B01F13/00B01F3/08C11B9/00A61K8/81A61K8/86A61K8/11A61Q13/00
CPCA61K8/11A61K8/8129A61K8/86A61Q13/00B01J13/06C11B9/0046A61K9/5026A61K9/5089C09K15/08A61K2800/56B01F23/4144B01F23/41B01F2025/918B01F25/313B01F33/3011B01F33/3022B01F33/813Y10T428/2984A61K2800/412B01F25/20B01F23/4143B01J13/14
Inventor J·C·韦斯纳M·卡吉奥尼朱滔滔D·A·韦茨A·阿布斯波尔德C-H·崔
Owner PROCTER & GAMBLE CO
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