Applications of Sarcaboside A in medicament against helicobacter pylori
A technology for anti-helicobacter pylori and drugs, which is applied in the field of preparation of anti-helicobacter pylori drugs, can solve problems such as indigestion and the destruction of bacterial flora in the digestive tract, and achieve the effect of strong inhibitory activity and outstanding substantive characteristics
Inactive Publication Date: 2013-12-18
NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH
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Problems solved by technology
The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; another serious problem is that proton pump inhibitors can induce indigestion, and a large amount of antibacterial agents can lead to serious destruction of the intestinal flora
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0012] Embodiment 1: the preparation of compound Sarcaboside A tablet involved in the present invention:
[0013] Take 20 grams of compound Sarcaboside A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.
Embodiment 2
[0014] Embodiment 2: the preparation of compound Sarcaboside A capsule involved in the present invention:
[0015] Get 20 grams of compound Sarcaboside A, add conventional adjuvants for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0016] The following pharmacodynamic experiments will further illustrate its drug activity.
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Abstract
The invention relates to applications of Sarcaboside A in a medicament against helicobacter pylori. In-vitro activity experiments show that the Sarcaboside A has strong activity against the Helicobacter pylori Hp. The Sarcaboside A can be used for treating diseases of acute and chronic gastritis, gastric ulcer, duodenal ulcer and the like, and can be applied to preparing medicaments for preventing acute and chronic gastritis, gastric ulcer and duodenal ulcer. The applications of the Sarcaboside A in the medicament against helicobacter pylori are disclosed for the first time. As a skeleton type of the Sarcaboside A belongs to a brand-new skeleton type, the Sarcaboside A has unexpectedly strong helicobacter pylori inhibition activity, and the possibility of giving any inspiration by other compounds does not exist. The Sarcaboside A has significantly substantive characteristics, as well as obviously prominent progress in the prevention and treatment of the helicobacter pylori infection.
Description
technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to the application of Sarcaboside A in the preparation of anti-helicobacter pylori drugs. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative spiral bacterium. Studies have shown that Helicobacter pylori is the main cause of acute and chronic gastritis and gastric and duodenal ulcers, and may be related to gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. Recently, the World Health Organization classified Hp as a class I carcinogen, which plays a leading role in the development of gastric cancer. The current popular treatment for Hp infection is the triple therapy of proton pump inhibitor (PPI) plus two antibiotics (choose two from clarithromycin, amoxicillin, tetracycline, metronidazole, etc.). The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacter...
Claims
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IPC IPC(8): A61K31/365A61P31/04
Inventor 江春平张广
Owner NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH