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Traditional Chinese medicine compound granules for treating infantile asthma and preparation method thereof

A technology for pediatric asthma and traditional Chinese medicine, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of large oral doses, inconvenient to carry, and go to the hospital, and achieves low dosage and convenient transportation and portability. , the effect of good application prospects

Inactive Publication Date: 2013-12-18
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 2. Large oral dose, bitter taste, more difficult for children to take
[0005] 3. Inconvenient to use
Modern life is becoming more and more tense. Patients rarely have the time to decoct a pair of traditional Chinese medicine for 2-3 times, and take it now. Many Chinese medicine hospitals have launched the business of substituting traditional Chinese medicine for decoction. Even if it can solve the problem of difficult decoction for some patients, However, there are still problems such as large volume of decoction, inconvenient to carry, and need to go to the hospital frequently

Method used

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  • Traditional Chinese medicine compound granules for treating infantile asthma and preparation method thereof
  • Traditional Chinese medicine compound granules for treating infantile asthma and preparation method thereof
  • Traditional Chinese medicine compound granules for treating infantile asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The research of the preparation method of the traditional Chinese medicine compound granule of embodiment 1 treatment infantile asthma

[0029] According to the nature of the drug in the prescription, this product is divided into alcohol extraction part and water extraction part, and amygdalin and ephedrine hydrochloride are used as index components, and extraction time, extraction times, solvent dosage, ethanol in alcohol extraction part Concentration is an investigation factor, and it has carried out three levels of orthogonal experiments of each factor; Investigate different concentration methods and concentration temperature, select the suitable concentration condition; Contrast the retention rate of ephedrine hydrochloride and the index component ephedrine hydrochloride of three kinds of refining methods. Impurity rate, screen the refining method and refining conditions suitable for this product; investigate the type and amount of auxiliary materials, the type and a...

Embodiment 2

[0037] Example 2 Alcohol Extraction Process of Bitter Almond, Salvia Miltiorrhiza, and White Mustard Seed Three-flavor Medicinal Pieces in Extraction Process Research

[0038] 1. Orthogonal test

[0039] According to the physical and chemical properties and pharmacological properties of these three traditional Chinese medicines, alcohol extraction was used to extract them, taking the yield of amygdalin and extract as indicators, and orthogonal experiments were used to investigate the influencing factors such as ethanol concentration, ethanol dosage, extraction time, and extraction times. The degree of influence on the two indicators. The specific experimental design and results are shown in Tables 1-5.

[0040] Table 1 Alcohol extraction process orthogonal test factor level table

[0041]

[0042] Table 2 Orthogonal experimental design and experimental results (influence on the content of amygdalin)

[0043]

[0044]Table 3 Analysis of variance of amygda...

Embodiment 3

[0064] Example 3 The water extraction process of ephedra, rhubarb, Tinglizi, licorice, melon peel, and knotweed 6 traditional Chinese medicines and alcohol extraction dregs of extraction process research

[0065] 1. Orthogonal test factor level table

[0066] Combining decoction of ethanol-extracted medicinal residues and ephedra can embody the characteristics of co-decoction in traditional decoctions of traditional Chinese medicine compound recipes, so that the water-soluble active ingredients in the whole prescription can be fully extracted. Take ephedrine hydrochloride content, total anthraquinone content and extract yield as index, carry out L 9 (3 4 ) orthogonal test to optimize the three main factors affecting the water extraction process, and determine the levels of these three influencing factors on the basis of literature.

[0067] Table 7 water extraction process orthogonal test factor level table

[0068]

[0069] 2. Determination of water absor...

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Abstract

The invention provides traditional Chinese medicine compound granules for treating infantile asthma and a preparation method thereof. Decoction for purging lung and relieving asthma is made into the granules by applying modern science and technology in combination with clinical requirements and medicine natures according to the application status of the decoction for purging lung and relieving asthma, which is clinically proven recipe. The preparation method comprises the extraction of effective ingredients and the preparation of the granules. The preparation technology comprises an extraction process, a concentration process, a purification process and a forming process. Compared with conventional decoction, the granules prepared by the technology have the advantages that the main effective ingredients of the decoction are retained, the appearance, the granularity, the moisture, the solubility and the like of the granules reach pharmacopeia requirements, the quality of the granules is stable in comparison with the quality of liquid preparations such as oral liquid and mixtures, the dosage is little, the granules are convenient to transport and carry and have good mouth feel, the children compliance is improved, and after being brewed, the granules have good mouth feel by using a flavoring agent for changing the mouth feel and are easy to accept by children and the like. Meanwhile, the production method can be used for realizing industrial production and mechanical packaging technically. Therefore, the decoction for purging lung and relieving asthma is modified into the granules with relatively good application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a dosage form modification of a clinically proven prescription for treating children with asthma and a preparation method thereof. Background technique [0002] As a proven prescription with definite curative effect, Xiefei Pingchuanling is used clinically in the form of decoction. Decoction, also known as soup liquid, refers to a liquid dosage form made by decocting or soaking decoction pieces of Chinese herbal medicine to remove residue and extract juice. The following summarizes the disadvantages in the use of decoction. [0003] 1. Due to the limitation of the solvent. Some fat-soluble and insoluble ingredients are not completely decocted. For example, ores, shellfish, and hornet-like medicines have these phenomena. Gypsum, tortoise shell, mother-of-pearl, etc. need to be smashed and fried for about 30 minutes before boiling; some...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/16A61P11/06
Inventor 巢建国韩新民谷巍丁小静
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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