Peritoneal dialysis solution

A peritoneal dialysate and osmotic agent technology, applied in the field of peritoneal dialysate containing pirfenidone, can solve the problems of fibrosis and loss of function, hypertrophy of peritoneal mesothelial cells, impaired peritoneal defense function, etc. fibrosis, blocking the effect of peritoneal fibrosis

Active Publication Date: 2013-12-25
HUAREN PHARMACEUTICAL CO LTD
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AI Technical Summary

Problems solved by technology

Other studies have found that high-sugar peritoneal dialysate can lead to hypertrophy of peritoneal mesothelial cells. Hypertrophic mesothelial cells are a manifestation of early cell aging, which may be related to peritoneal damage, and ultimately impair the peritoneal defense function against infection and fibrosis , leading to fibrosis and progressive loss of function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 7

[0033] Embodiment 7 anti-peritoneal fibrosis evaluation

[0034] 1. Purpose of the experiment

[0035] Through comparative analysis of indicators: rat peritoneal thickness and rat ascites and TGF-β in blood 1 Concentration, to evaluate the anti-peritoneal fibrosis effect of the peritoneal dialysis solution in Examples 1-4 of the present invention.

[0036] 2. Experimental method

[0037] (1) Determination of rat peritoneal thickness

[0038] The peritoneal dialysis solution described in Comparative Example and Examples 1-6 was put into a three-layer co-extrusion film bag for infusion, and sterilized by moist heat at a sterilization temperature of 115° C. and a sterilization time of 30 minutes.

[0039] 80 male SD rats were divided into 8 groups according to the random number table, that is, group A-group H, 10 in each group, wherein, group A was used as the normal control group, and 20ml of normal saline was injected intraperitoneally; the rest were treated with 4.25% gluco...

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Abstract

The invention discloses a peritoneal dialysis solution which comprises 0.01-5%w/v pirfenidone. Through a good deal of experimental research and analysis, the process that the 0.01-5%w/v pirfenidone is added to a conventional peritoneal dialysis solution so that peritoneum fibrosis caused by high-concentration glucose in an existing peritoneal dialysis solution can be remarkably blocked and delayed is found out.

Description

technical field [0001] The invention relates to a peritoneal dialysis solution, in particular to a peritoneal dialysis solution containing pirfenidone. Background technique [0002] As a method for treating patients with end stage renal disease (ESRD), peritoneal dialysis has been widely used in recent years because of its special advantages such as treatment, easy operation, reduction of blood-borne disease transmission, and protection of residual renal function. Applications. The principle is that the peritoneum is used as a semipermeable membrane, and the fresh dialysate is constantly replaced to achieve the purpose of removing excess water and toxins in the body. Compared with the dialysis membrane of hemodialysis, the peritoneum has a larger pore size, so it can remove large, medium and small molecule toxins. However, ultrafiltration failure and peritoneal injury continue to challenge the further development of peritoneal dialysis technology. [0003] At present, onl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4418A61P7/08A61K31/7004A61K33/14A61K33/06A61K33/00
Inventor 李继仁沈圣民
Owner HUAREN PHARMACEUTICAL CO LTD
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