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New method for extracting glycyrrhizic acid from liquorice

A technology of glycyrrhizic acid and a new method, applied in the field of phytochemistry, can solve the problems of long extraction time, low extraction purity, environmental pollution, etc., and achieve the effects of easy industrial production, high product purity, and high extraction efficiency.

Inactive Publication Date: 2013-12-25
NANJING TONGZE AGRI SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods all have many disadvantages, such as long extraction time, low extraction purity, difficult separation of extractant from product, and environmental pollution, etc., which are not suitable for industrial production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Crush the licorice, add petroleum ether (60~90°C) 8 times the weight of licorice, and extract it in an ultrasonic wave for 60 minutes with a power of 300W to remove fat-soluble components, take it out, filter it with suction, dry the filter residue, and add 15 times its weight Put the water in the microwave, the microwave power is 200W, the time is 10min, take out and filter, the filtrate is concentrated to 1 / 15 of the original volume, adjust its pH value with concentrated sulfuric acid, let it stand for precipitation of glycyrrhizic acid, and then centrifuge Separated to obtain crude glycyrrhizic acid, recrystallized twice with 50% ethanol, and dried to obtain finished glycyrrhizic acid with a purity of 95.6%.

Embodiment 2

[0015] Crush licorice, add petroleum ether (60-90°C) 10 times the weight of licorice, and extract in ultrasonic for 60 minutes with a power of 300W to remove fat-soluble components, take it out, filter with suction, dry the filter residue, add 20 times its weight Put the water in the microwave, the microwave power is 250W, the time is 7min, take out and filter, the filtrate is concentrated to 1 / 20 of the original volume, adjust its pH value with concentrated sulfuric acid, let stand, make the glycyrrhizic acid precipitate out, and then centrifuge Separated to obtain crude glycyrrhizic acid, recrystallized twice with 60% ethanol, and dried to obtain finished glycyrrhizic acid with a purity of 98.2%.

Embodiment 3

[0017] Crush the licorice, add petroleum ether (60~90°C) 9 times the weight of licorice, and extract it in an ultrasonic wave for 60 minutes with a power of 300W to remove fat-soluble components, take it out, filter it with suction, dry the filter residue, and add 18 times its weight Put the water in the microwave, the microwave power is 300W, the time is 5min, take out and filter, the filtrate is concentrated to 1 / 18 of the original volume, adjust its pH value with concentrated sulfuric acid, let it stand for precipitation of glycyrrhizic acid, and then centrifuge Separated to obtain crude glycyrrhizic acid, recrystallized twice with methanol, and dried to obtain finished glycyrrhizic acid with a purity of 96.8%.

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Abstract

The invention discloses a new method for extracting glycyrrhizic acid from liquorice, and particularly relates to a method combining ultrasonic waves and microwaves. The method comprises the treatment steps of grinding liquorice; adding petroleum ether (60-90 DEG C) 8-10 times the liquorice mass, and placing in ultrasonic waves to remove liposoluble components; taking out the product, and performing suction filtration; drying the filter residue, adding water 15-20 times the weight of the filter residue, and placing in microwaves, wherein the microwave power is 200-300 W, and the time is 5-10 minutes; taking out the product and filtering; concentrating the filtrate to 1 / (15-20) of the original volume; adjusting the pH value by use of concentrated sulfuric acid to precipitate glycyrrhizic acid; performing centrifugal separation to obtain coarse glycyrrhizic acid; re-crystallizing twice and drying to obtain a finished product of glycyrrhizic acid. According to the method disclosed by the invention, the liposoluble components in liquorice are sufficiently removed by use of the effect of ultrasonic waves, and glycyrrhizic acid is extracted in combination with the high-energy effect of microwaves. The method has the advantages of simple process, high extraction efficiency, high product purity and environmental friendliness, and facilitates industrial production.

Description

technical field [0001] The invention discloses a new method for extracting glycyrrhizic acid from licorice, in particular relates to a method combining ultrasonic waves and microwaves, and belongs to the technical field of phytochemistry. Background technique [0002] Glycyrrhizic acid, also known as glycyrrhizin, is the main active ingredient in licorice. It is a white crystalline powder, odorless, with a special sweet taste. It is insoluble in cold water and ether, soluble in hot water, and easily soluble in ethanol and acetone. It is characterized by high sweetness (its sweetness is 200~300 times that of sucrose), low heat energy, safety and non-toxicity, low foaming and hemolysis, and can be widely used in food, beverage, medicine, cosmetics, tobacco, etc. industry. Glycyrrhizic acid not only has the functions of sweetening, flavoring and flavoring, but also anti-inflammatory, anti-allergic, detoxifying, antitussive, anti-tumor, affecting lipid metabolism, and inhibitin...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256C07H1/08
Inventor 杨存
Owner NANJING TONGZE AGRI SCI & TECH
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