Medical polymer material with radioactive nuclide marker, and preparation method as well as application thereof

A technology of polymer materials and radionuclides, which is applied in the direction of radioactive carriers, drug combinations, antineoplastic drugs, etc., can solve the problems of cumbersome operation, increased radionuclide decay, and residual organic solvents, etc., to achieve high product purity, Avoid cumbersome effects

Active Publication Date: 2014-01-08
MITRO BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The second technical problem to be solved by the present invention is that in the prior art, the separation and purification of radionuclide-labeled compounds by chromatography is cumbersome, resulting in an increase in the decay of radionuclide; and organic solvents

Method used

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  • Medical polymer material with radioactive nuclide marker, and preparation method as well as application thereof
  • Medical polymer material with radioactive nuclide marker, and preparation method as well as application thereof
  • Medical polymer material with radioactive nuclide marker, and preparation method as well as application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Prepared in this example 18 f - The preparation process of the medical macromolecular material containing amino groups and molecular weight of 4000 comprises the following steps:

[0035] S01: pass 18 O(p,n) 18 F reacts to generate carrier-free 18 f - , and enrich it on the QMA column, with K 2 CO 3 / K 2,2,2 The acetonitrile solution will18 f - Elute to the first reaction tube, heat with nitrogen gas, and evaporate the solution to dryness; add 2 mL of acetonitrile into the reaction tube, heat with nitrogen gas, evaporate the solution to dryness, and cool the first reaction tube to 40°C;

[0036] S02: Add acetonitrile solution containing SFB precursor to the first reaction tube, react at 116°C for 600s, mix the solution once every 200s with nitrogen flow, 5s each time; add 0.5mL0.5mol / L to the reaction tube NaOH was hydrolyzed at 90°C for 300 s, and the solution was mixed once every 100 s with nitrogen flow, 5 s each time; the alkali was neutralized with a mixed...

Embodiment 2

[0041] Prepared in this example 18 f - The preparation process of the medical macromolecular material containing amino groups and molecular weight of 5000 comprises the following steps:

[0042] S01: pass 18 O(p,n) 18 F reacts to generate carrier-free 18 f - , and enrich it on the QMA column, with K 2 CO 3 / K 2,2,2 The acetonitrile solution will 18 f - Elute to the first reaction tube, heat with nitrogen gas, and evaporate the solution to dryness; add acetonitrile into the reaction tube, heat with nitrogen gas, evaporate the solution to dryness, and cool the first reaction tube to 35°C;

[0043] S02: Add acetonitrile solution containing SFB precursor to the first reaction tube, react at 110°C for 600s, mix the solution once every 200s with nitrogen flow, 5s each time; add 0.25mL1mol / L NaOH to the reaction tube , 85°C reaction hydrolysis for 300s, the solution was mixed once every 100s with nitrogen flow, 5s each time; the alkali was neutralized with a mixed solution ...

Embodiment 3

[0048] Prepared in this example 18 f - The preparation process of the medical macromolecular material containing amino groups and molecular weight of 4000 comprises the following steps:

[0049] S01: pass 18 O( p ,n) 18 F reacts to generate carrier-free 18 f - , and enrich it on the QMA column, with K 2 CO 3 / K 2,2,2 The acetonitrile solution will 18 f - Elute to the first reaction tube, heat with nitrogen gas, and evaporate the solution to dryness; add acetonitrile into the reaction tube, heat with nitrogen gas, evaporate the solution to dryness, and cool the first reaction tube to 45°C;

[0050] S02: Add acetonitrile solution containing SFB precursor to the first reaction tube, react at 120°C for 600s, mix the solution once every 200s with nitrogen flow, 5s each time; add 0.5mL0.5mol / L to the reaction tube NaOH was hydrolyzed at 95°C for 300 s, and the solution was mixed once every 100 s with nitrogen flow, 5 s each time; the alkali was neutralized with a mixed so...

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Abstract

The invention relates to a medical polymer material with a radioactive nuclide marker, and a preparation method as well as application thereof, and belongs to the technical field of medicine and pharmacology. The medical polymer material with the radioactive nuclide marker is structurally a 18F<->-SFB-medical polymer material. The preparation of the medical polymer material with the 18F-marker comprises the steps of: reacting 18F<-> with an SFB precursor to obtain 18F<->-FBA; then reacting 18F<->-FBA with TSTU to obtain 18F<->-SFB; finally reacting the medical polymer material with triethylamine and 18F<->-SFB, and then centrifuging and washing to obtain the medical polymer material with the 18F<->marker. According to the provided method, the marked medical polymer material is separated and purified through the adoption of a centrifugal crystallization way, and the centrifuged product is a solid. The preparation method of the medical polymer material with the radioactive nuclide marker avoids the problems of increased attenuation amount of radionuclide and organic solvent residue caused by fussy operation of a chromatography in the prior art efficiently, and the obtained product has higher purity which can be more than 95%.

Description

technical field [0001] The present invention relates to a radionuclide 18 An F-marked medical polymer material and a preparation method and application thereof belong to the technical field of medicine. Background technique [0002] Medical polymer materials are a kind of synthetic polymer materials that can repair, replace and regenerate organism tissues and have special functions. Since medical polymer materials can have different physical and chemical properties through the control of composition and structure to meet different needs, they are resistant to biological aging and have good biological stability and physical and mechanical properties as long-term implant materials. It is easy to process and shape, easy to obtain raw materials, and easy to sterilize and sterilize. Therefore, it has attracted widespread attention and has become the most widely used and largest variety of biological materials. It is often used in the diagnosis, treatment, replacement or repair o...

Claims

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Application Information

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IPC IPC(8): A61K51/06A61P35/00A61K101/02
Inventor 刘强李新平颜成龙徐建锋瞿凌晨王燕
Owner MITRO BIOTECH CO LTD
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