Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A method for extracting parthenolide from plant raw materials

A technology of parthenolide and plant raw materials, which is applied in the production of bulk chemicals and organic chemistry, can solve the problems of wasting organic solvents, high impurity content, and high production costs, and achieve low cost, simple extraction process, and high efficiency. Effect

Active Publication Date: 2015-12-09
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Chinese patents CN102241684A and CN102863452A disclose the solvent extraction method of parthenolide, which belongs to the traditional steaming and decocting method, with high content of impurities (wax), and cumbersome operation, waste of a large amount of organic solvent, great environmental pollution, and high production cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method for extracting parthenolide from plant raw materials
  • A method for extracting parthenolide from plant raw materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1) Firstly, dry the leaves of Michelia chinensis naturally, crush them, and sieve them through a 10-mesh sieve to obtain Michelia milmilia leaf powder;

[0030] 2) Set the temperature of the extraction cylinder to 35°C, the temperature of the separation cylinder I to 50°C, and the temperature of the separation cylinder II to 40°C;

[0031] 3) Put the cylinder containing 500g of Michelia chinensis powder into the extraction tank and add 500mL of 90% methanol;

[0032] 4) Start the carbon dioxide circulation system, adjust the pressure of the extraction cylinder to 15MPa, the pressure of the separation cylinder I to 10MPa, and the pressure of the separation cylinder II to 6MPa. Adjust the mass flow rate of carbon dioxide corresponding to each kilogram of raw material (Smilax micheliae powder) to 0.5kg / h. When the temperature and pressure reach the set value, start to record the time. After 1 hour of extraction, release the extract from the discharge port of separation cy...

Embodiment 2

[0039] 1) Firstly, dry the leaves of Michelia chinensis naturally, crush them, and sieve them through a 20-mesh sieve to obtain Michelia milmilia leaf powder;

[0040] 2) Set the temperature of the extraction cylinder to 40°C, the temperature of the separation cylinder I to 55°C, and the temperature of the separation cylinder II to 45°C;

[0041] 3) Put the cylinder containing 700g of Michelia chinensis powder into the extraction tank and add 1L of 90% methanol;

[0042] 4) Start the carbon dioxide circulation system, adjust the pressure of the extraction cylinder to 17.5MPa, the pressure of the separation cylinder I to 12.5MPa, and the pressure of the separation cylinder II to 6MPa. Adjust the mass flow rate of carbon dioxide corresponding to each kilogram of raw material (Smilax micheliae powder) to 1.0kg / h. When the temperature and pressure reach the set value, start to record the time, and then release the extract from the discharge port of the separation cylinder II thre...

Embodiment 3

[0046] 1) First, dry and crush the leaves of Michelia chinensis, and sieve through a 30-mesh sieve to obtain powder of Michelia chinensis leaves;

[0047] 2) Set the temperature of the extraction cylinder to 45°C, the temperature of the separation cylinder I to 60°C, and the temperature of the separation cylinder II to 50°C;

[0048] 3) Put the barrel containing 1kg of Michelia chinensis powder into the extraction tank;

[0049] 4) Start the carbon dioxide circulation system, adjust the pressure of the extraction cylinder to 20MPa, the pressure of the separation cylinder I to 15MPa, and the pressure of the separation cylinder II to 6MPa. Adjust the mass flow rate of carbon dioxide corresponding to every kilogram of raw material (Smilax smilax powder) to be 1.5kg / h. When the temperature and pressure reach the set value, start to record the time, and then release the extract from the discharge port of the separation cylinder II three times after 1h, 3h, and 5h respectively (the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a method for extracting parthenolide from a plant raw material, which comprises the following steps: naturally airing collected plant raw material leaves, pulverizing, and screening to obtain leaf powder; and performing carbon dioxide supercritical extraction, stirring the extract with silica gel, passing through a silica gel column based on a dry process, performing gradient elution, and recrystallizing to obtain the parthenolide monomer of which the purity is more than 99%. According to the invention, the parthenolide monomer is extracted through supercritical extraction-silica gel column chromatography-recrystallization; the method has the characteristics that the extraction process is simple, the efficiency is high, the effective components are not destroyed, CO2 gas can be circularly used, a complicated extraction course is not required and the like; and the method can realize comprehensive utilization maximization of the resources, is low in industrial production cost, and has wide application prospects and significant social meanings and economic value.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction, and in particular relates to a step-by-step extraction method of parthenolide. Background technique [0002] Michelia hedyosperma (scientific name: Micheliahedyosperma) is an ornamental plant of the genus Michelia magnolia, distributed in Hainan (Bawangling, southeast of Baisha), southwestern Guangxi, and Yunnan (Xishuangbanna). Its seeds can be used as medicinal and seasoning spices. According to the chemical analysis of Chinese herbal medicines, the plants of this genus contain parthenolide, an anti-tumor active ingredient. [0003] Malignant tumor is one of the major diseases that seriously endanger human health and life. The latest statistics released by the World Health Organization (WHO) show that in 2008, there were about 12.7 million new cancer cases worldwide and about 7.6 million deaths; in my country, there were about 2.8 million new cancer cases and about 2 million death...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04
CPCC07D493/04Y02P20/54
Inventor 秦向阳李涛何炜刘建强李志全吕凌云
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com