Method for manufacturing pharmaceuticals from molten materials
A technology of melting material and cover, applied in the direction of extrusion granulation of raw materials, powder conveying, block conveying, etc., which can solve the problems of clogging, stickiness, and poor blade cooling.
Active Publication Date: 2015-11-25
AUTOMATIK PLASTICS MASCH GMBH
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- Abstract
- Description
- Claims
- Application Information
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Problems solved by technology
The problems with these systems are: poor cooling of the blades, which overheat and become sticky after a period of time; and the overall tendency of these systems to stick and clog, especially with the large quantities of particles that are to be produced under actual manufacturing conditions. at high production rates
Method used
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Embodiment Construction
[0008] According to the invention, this object is achieved with a method having the features of claim 1 . Preferred embodiments of the invention are defined in the dependent claims.
[0009] In the method according to the invention for the manufacture of pharmaceuticals from molten material, the molten material is discharged from nozzles of a perforated plate, and subsequently granulated, wherein a motor-driven cutter arrangement having at least one blade is placed opposite the perforated plate so that the at least one blade passes over a nozzle of said perforated plate, thereby cutting the discharged molten material into particles, wherein an enclosure is provided adjoining said perforated plate and enclosing at least one blade of said cutting machine arrangement, flowing a coolant through the enclosure whereby in the process particles of the molten material are subsequently solidified in the coolant which is introduced into the enclosure from an inlet device comprising a sep...
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Abstract
The invention relates to a method for the manufacture of pharmaceuticals from molten material, wherein said molten material is discharged from nozzles of a perforated plate and subsequently granulated, wherein a motor-driven cutter arrangement having at least one blade is placed opposite said perforated plate, The at least one blade is passed over the nozzle of the perforated plate and thereby cuts the discharged molten material to obtain particles. There is provided a casing connected to the perforated plate and arranged at least around the at least one blade of the cutter, wherein a cooling medium is flowed through the casing so that particles of the molten material are solidified in the cooling medium, the cooling The medium is introduced radially inwardly or substantially radially inwardly from the outside from an inlet arrangement consisting of separate inlets around the circumference of the housing in the region of rotation of the at least one blade and from the inlet nozzle arrangement chamber, the inlet nozzle is arranged between the inlet chamber and the housing. A centripetal or at least substantially centripetal flow of coolant is produced at least in the region of rotation, furthermore the cooling medium and the particles contained therein are supplied to the outlet of the housing, wherein the cooling medium is a gaseous cooling medium .
Description
technical field [0001] The invention relates to a method for the manufacture of pharmaceuticals from molten materials according to the preamble of claim 1 . Background technique [0002] Currently, molten materials are typically processed by, for example, pelletizing. In general, extruders or melt pumps are often used for the pelletizing of molten materials, and so far especially for pelletizing, for example, plastics. These extruders or melt pumps extrude molten plastic material through nozzles of a perforated plate into a coolant such as water. In this method, molten material discharged through a nozzle opening is cut using a cutter arrangement having at least one rotating blade to produce particles. For example, a corresponding device for carrying out the underwater granulation method is called an underwater granulator, for example from the company AutomatikPlasticsMachineryGmbH under the trade name underwater granulator. [0003] Published German unexamined patent a...
Claims
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IPC IPC(8): A61K9/16B29B9/06B29C48/04
CPCA61K9/1682B29C2035/1658A61K9/146A61K9/148B01J2/20B29C48/04B29B9/065B29B9/06A61K9/16
Inventor 林哈特-卡斯滕·穆布
Owner AUTOMATIK PLASTICS MASCH GMBH