2,4-dibenzyloxybenzoic acid derivatives and their preparation methods and applications

A technology of dibenzyloxybenzoic acid and derivatives, applied in 2 fields, can solve the problems of low oral bioavailability of peptide antagonists, limit the application of cardiovascular diseases, etc., and achieve the effect of strong endothelin receptor antagonistic activity
CN103539659BActive Publication Date: 2015-11-18SOUTHEAST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHEAST UNIV
Publication Date
2015-11-18

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Abstract

The invention provides a 2,4-dibenzyloxybenzoic acid derivative shown by a formula (I) or pharmaceutically acceptable salts thereof, and also provides a preparation method of the 2,4-dibenzyloxybenzoic acid derivative or pharmaceutically acceptable salts thereof and an application thereof in preparing a medicine for treating cardiovascular and cerebrovascular diseases, tumors, diabetes mellitus, nephrosis, asthma or hyperthyroidism.
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Description

technical field

[0001] The invention belongs to the field of medicine and chemical industry, and particularly relates to 2,4-dibenzyloxybenzoic acid derivatives, as well as its preparation method and application. Background technique

[0002] The mortality rate of cardiovascular and cerebrovascular diseases ranks first among all kinds of diseases, and the final cause of death is overwhelmingly myocardial hypertrophy, heart failure (heart failure), stroke or fatal arrhythmia. Especially in recent years, the fatality rate of severe heart failure has remained high, which has become a difficult problem in the international medical community. These diseases currently lack effective therapeutic drugs.

[0003] Endothelin (endothclin, ET) is an active polypeptide containing 21 amino acids synthesized and secreted by vascular endothelial cells, cardiac muscle, smooth muscle, etc. Injury factors play an important role in the pathogenesis of many heart, brain, lung, kidney and vascu...

Claims

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