Anticoccidial compound origanum oil oral nano emulsion for poultry and preparation method thereof

A technology for anticoccidial and milk preparations, which is applied to medical preparations containing active ingredients, anti-infective drugs, and pharmaceutical formulas, etc., and can solve problems such as inability to fully utilize drug effects, slow drug dissolution rate, and poor bioavailability , to achieve the effects of reducing the first-pass effect, promoting gastrointestinal absorption, and increasing the oil-water property and rigidity

Inactive Publication Date: 2014-02-05
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing studies have shown that: toosendanin, green tea extract, lentinan, etc. have anthelmintic effects, and oregano oil is also used as an adjuvant for anthelmintics on the market, but these drugs can be absorbed from the gastrointestinal tract after oral administration, but the absorption incomplete
In addition, the dissolution rate of the medicine is slow and the bioavailability is poor. In addition, the effects of toosendanin, green tea extract, and lentinan are slow, so that the drug effects of toosendanin, green tea extract, lentinan, etc. and oregano oil cannot be fully utilized.

Method used

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  • Anticoccidial compound origanum oil oral nano emulsion for poultry and preparation method thereof
  • Anticoccidial compound origanum oil oral nano emulsion for poultry and preparation method thereof
  • Anticoccidial compound origanum oil oral nano emulsion for poultry and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] An oral nanoemulsion preparation of poultry anticoccidial compound oregano oil, which is made of the following proportions of raw materials: oregano oil 11g, castor oil polyoxyethylene ether 40 (EL40) 32g, absolute ethanol 7g, toosendanin 6g , green tea extract 8g, lentinan 7g, proanthocyanidin 0.3g and water 28.7g.

[0052] The preparation method of the poultry anti-coccidial compound oregano oil oral nanoemulsion preparation comprises the following steps: taking oregano oil, surfactant and co-surfactant in proportion and stirring evenly at room temperature (25°C); Then slowly drop into it the aqueous solution dissolved with toosendanin, green tea extract, lentinan and proanthocyanidin, and mix well.

Embodiment 2

[0054] A poultry anti-coccidial compound oregano oil oral nanoemulsion preparation, which is made of the following proportions of raw materials: oregano oil 7.5g, EL40 26g, 1,2-propylene glycol 12g, toosendanin 5g, green tea extract 3g, Lentinan 8g, procyanidins 0.6g and water 37.9g.

[0055] Refer to Example 1 for the preparation method of the poultry anti-coccidial compound oregano oil oral nanoemulsion preparation.

Embodiment 3

[0057] A poultry anti-coccidial compound oregano oil oral nanoemulsion preparation, which is made of the following proportions of raw materials: oregano oil 9.5g, polyoxyethylene 40 hydrogenated castor oil (RH40), 25g, glycerol 18g, toosendan Green tea extract 8g, green tea extract 7g, lentinan 6g, proanthocyanidin 0.5g and water 26g.

[0058] Refer to Example 1 for the preparation method of the poultry anti-coccidial compound oregano oil oral nanoemulsion preparation.

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Abstract

The invention relates to an anticoccidial compound origanum oil oral nano emulsion for poultry. The anticoccidial compound origanum oil oral nano emulsion is prepared from the following raw materials in percentage by weight: 1%-30% of origanum oil, 10%-40% of a surfactant, 1%-20% of a cosurfactant, 1%-20% of toosendanin, 1%-20% of a green tea extract, 1%-20% of lentinan, 0.1%-10% of procyanidine and the balance being water; the sum of the weight percentages of the raw materials is 100%. According to the oral nano emulsion, the origanum oil and the purely-natural plant extract are combined, and the oral nano emulsion with the formula is healthy and reasonable, has high safety, has double effects of health care and treatment and has an obvious anticoccidial curative effect.

Description

technical field [0001] The invention belongs to the technical field of medicines for poultry, and in particular relates to an oral nanoemulsion preparation of anticoccidial compound oregano oil for poultry and a preparation method thereof. Background technique [0002] Existing studies have shown that toosendanin, green tea extract, lentinan, etc. have anthelmintic effects, and oregano oil is also used as adjuvant for anthelmintics on the market, but these drugs can be absorbed from the gastrointestinal tract after oral administration. incomplete. The dissolution rate of medicine is slow in addition, and bioavailability is poor, add toosendanin, green tea extract, lentinan action slowly, make the drug effect of toosendanin, green tea extract, lentinan etc. and oregano oil can not be fully utilized. Contents of the invention [0003] Aiming at the deficiencies in the prior art, the object of the present invention is to provide a poultry anticoccidial compound oregano oil o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/107A61P33/02A61K31/352A61K31/715A61K31/58
Inventor 孙江宏曾萍张雯雯岳旭龙
Owner HENAN SOAR VETERINARY PHARMA
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