Preparation method of porous hydroxyapatite biological ceramic material

A bioceramic material, hydroxyapatite technology, applied in the field of biomedical materials, can solve the problems of low strength of porous HA bioceramics, limit the promotion and application of bone repair materials, etc., and achieve compressive strength optimization, high porosity, and pore connectivity. Good results

Active Publication Date: 2014-11-05
NORTH CHINA INST OF AEROSPACE ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are many research reports on the preparation methods of porous HA bioceramics, each of these preparation methods has its own advantages and disadvantages, and the low strength of porous HA bioceramics also limits its further application as a bone repair material.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The commercially available submicron hydroxyapatite powder is selected, and the particle shape is relatively uniform. Prepare a premix solution containing 20wt% tert-butanol, hydroxyethyl acrylate monomer and N,N'-methylenebisacrylamide in deionized water, tert-butanol accounts for 60% of the total mass of organic matter, N,N' - The weight ratio of methylenebisacrylamide and hydroxyethyl acrylate is 1:30. Prepare 20vol% hydroxyapatite slurry, ball mill for 24 hours, and the viscosity is less than 1Pa·s. Add 0.12ml of ammonium persulfate to 100ml of slurry at 25°C, inject the slurry into the mold, and directional freeze for 60 minutes in a low temperature environment of -40°C to form a frozen wet green body; then heat it with infrared rays at 70°C Quickly keep in the box for 20 minutes to obtain a dry porous hydroxyapatite body; put the dried porous hydroxyapatite body into a sintering furnace and keep it at 1250°C for 2 hours to obtain a porous hydroxyapatite biocerami...

Embodiment 2

[0027] The commercially available submicron hydroxyapatite powder is selected, and the particle shape is relatively uniform. Prepare a premix solution containing 20wt% tert-butanol, N-methylolacrylamide and N,N'-methylenebisacrylamide in deionized water, tert-butanol accounts for 60% of the total mass of organic matter, N,N The weight ratio of '-methylenebisacrylamide and N-methylolacrylamide is 1:30. Prepare 20vol% hydroxyapatite slurry, ball mill for 24 hours, and the viscosity is less than 1Pa·s. Add 0.12ml of ammonium persulfate to 100ml of slurry at 15°C, inject the slurry into the mold, and directional freeze for 60 minutes in a low temperature environment of -40°C to form a frozen wet green body; then heat it with infrared rays at 70°C Quickly keep in the box for 20 minutes to obtain a dry porous hydroxyapatite body; put the dried porous hydroxyapatite body into a sintering furnace and keep it at 1250°C for 2 hours to obtain a porous hydroxyapatite bioceramic material....

Embodiment 3

[0029] The commercially available submicron hydroxyapatite powder is selected, and the particle shape is relatively uniform. Prepare a premix solution containing 8wt% amphene, methacrylamide monomer and diisocyanate in deionized water, amphene accounts for 50% of the total mass of organic matter, and the weight ratio of diisocyanate and methacrylamide monomer is 1: 90. A 10vol% hydroxyapatite slurry was prepared and ball-milled for 48 hours, the viscosity was less than 1Pa·s. Add 2ml of benzoyl peroxide to 100ml of slurry at room temperature, inject the slurry into the mold, and freeze it for 200 minutes in a low temperature environment of -80°C to form a frozen wet green body; then place it in a 40°C infrared heating box Quickly hold for 60 minutes to obtain a dry porous hydroxyapatite body; put the dried porous hydroxyapatite body into a sintering furnace and keep it at 1000° C. for 3 hours to obtain a porous hydroxyapatite bioceramic material.

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Abstract

The invention relates to a preparation method of a porous hydroxyapatite biological ceramic material. According to the method, the porous hydroxyapatite biological ceramic material with better structural performance is obtained through organic combination of a freezing technology and a gel curing technology, and the application value of porous hydroxyapatite as a bone repair material is enhanced.

Description

technical field [0001] The invention relates to the preparation of a hydroxyapatite bioceramic material, in particular to a preparation method of a porous hydroxyapatite bioceramic material, which belongs to the field of biomedical materials. Background technique [0002] Hydroxyapatite (hydroxyapatite, HA or HAP, molecular formula [Ca 10 (PO 4 ) 6 (OH) 2 ]) is the most representative and most widely used bioactive ceramic, which has good biocompatibility and osteoconductivity when used as a bone graft material, and exhibits excellent chemical and biological affinity with bone tissue, so it can be widely used Materials used in the repair, replacement and function enhancement of biological hard tissues. [0003] Porous HA bioceramics can enhance osteoconductivity and induce osteogenesis, and its research and development have attracted more and more attention. Pore ​​morphology and size are important factors for porous HA to obtain good osseointegration ability. In addit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/06C04B35/447C04B35/622
Inventor 孙艳荣马利国李国洪范涛
Owner NORTH CHINA INST OF AEROSPACE ENG
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