Angelica sinensis and ligusticum wallichii tablet for regulating menstruation and preparation method of angelica sinensis and ligusticum wallichii tablet

A technology of Guishao Tiaojing Tablets and Angelica, which is applied in medical formulas, medical preparations with no active ingredients, and medical preparations containing active ingredients, etc. It can solve the problems of reducing the viscosity of drug particles, reducing drug stability, and easy volatilization of volatile oils, etc. problem, to achieve the effect of prolonging the shelf life, improving the dissolution and absorption rate, and facilitating disintegration

Active Publication Date: 2015-03-04
华润三九(郴州)制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above preparation methods have the following problems: directly spraying the volatile oil on the drug granules will not only reduce the viscosity of the drug granules, and cause difficulty in tablet compression; Difficulty disintegrating the drug

Method used

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  • Angelica sinensis and ligusticum wallichii tablet for regulating menstruation and preparation method of angelica sinensis and ligusticum wallichii tablet
  • Angelica sinensis and ligusticum wallichii tablet for regulating menstruation and preparation method of angelica sinensis and ligusticum wallichii tablet
  • Angelica sinensis and ligusticum wallichii tablet for regulating menstruation and preparation method of angelica sinensis and ligusticum wallichii tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of Guishao Tiao Jing tablet, comprising the following steps:

[0019] Step 101: Distill Angelica sinensis and Rhizoma Chuanxiong to obtain volatile oil and medicinal residues;

[0020] Step 102: mixing and homogenizing the volatile oil with β-cyclodextrin and water to obtain a suspension;

[0021] Step 103: Precipitate, filter, dry and pulverize the suspension in sequence to obtain clathrates of volatile oil;

[0022] Step 104: Mix the medicinal dregs with Bupleurum Radix, Radix Paeoniae Alba, Atractylodes Rhizoma Atractylodes Rhizome, Poria Cocos and Alisma, and then decoct to obtain a mixture;

[0023] Step 105: Filtering, concentrating, and granulating the mixed solution in sequence to obtain drug granules;

[0024] Step 106: Mix the inclusion compound of volatile oil with the drug granules, and then press into tablets to obtain Guishao Tiaojing Tablets;

[0025] Wherein, the volume ratio of the three components of volatile oil, β-cyclodextrin...

Embodiment 3

[0056] A preparation method of Guishao Tiao Jing tablet, comprising the following steps:

[0057] Dry cream powder: According to the prescription, make thick slices of Angelica and Chuanxiong, and crush other medicinal materials (Bupleurum, Radix Paeoniae Alba, Atractylodes Rhizoma Atractylodes Rhizome, Poria cocos, Alisma alisma) for later use. Angelica and Chuanxiong were infiltrated with appropriate amount of water for 2-4 hours, then distilled with water for 7 hours to extract volatile oil, and set aside; add water to decoct the dregs and other five-flavored medicinal materials such as Radix Paeoniae Alba, for 2 hours each time, combine and decoct, filter, and Concentrate the filtrate, angelica, and Chuanxiong medicine liquid to a clear paste with a relative density of 1.10-1.12 (60°C), add ethanol to make the content reach 50%, stir well, let stand overnight, take the supernatant, filter, and recover ethanol from the filtrate , concentrated to a thick paste with a relativ...

Embodiment 4

[0063] A Guishao Tiaojing tablet is composed of the following components: by weight, 1 part of Bupleuri, 1 part of Radix Paeoniae Alba, 1.2 parts of Atractylodes Rhizoma Atractylodes Rhizome, 1.2 parts of Poria cocos, 1 part of Angelica sinensis, 0.8 parts of Chuanxiong and 1 part of Alisma.

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Abstract

The invention relates to the field of a traditional Chinese medicine composition, and particularly relates to an angelica sinensis and ligusticum wallichii tablet for regulating menstruation and a preparation method of the angelica sinensis and ligusticum wallichii tablet. The preparation method of the angelica sinensis and ligusticum wallichii tablet for regulating menstruation comprises the following steps: distilling the angelica sinensis and the ligusticum wallichii to obtain essential oil and dregs; mixing the essential oil with beta-cyclodextrine and water, and homogenizing, so as to obtain suspension liquid; orderly precipitating, filtering, drying and crushing the suspension liquid, so as to obtain an essential oil inclusion compound; mixing the dregs with radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, tuckahoe and rhizoma alismatis; decocting, so as to obtain a mixed solution; orderly filtering, concentrating and pelletizing the mixed solution, so as to obtain drug particles; mixing the essential oil inclusion compound with the drug particles, and then tabletting, so as to obtain the angelica sinensis and ligusticum wallichii tablet for regulating menstruation. By adopting the angelica sinensis and ligusticum wallichii tablet for regulating menstruation and the preparation method of the angelica sinensis and ligusticum wallichii tablet, the viscosity of the drug particles is increased, tabletting is easier, the difficulty of the production technology is reduced, the stability of the drug is improved, the quality guarantee period is prolonged, and disintegration of the drug is facilitated, so that the dissolution and absorption rate of the drug is improved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine compositions, in particular to Guishao Tiaojing tablets and a preparation method thereof. Background technique [0002] Guishao Tiaojing Tablet is a traditional Chinese medicine composition used to treat irregular menstruation. Its main ingredients include: Bupleurum, Radix Paeoniae Alba, Atractylodes Rhizoma Atractylodes Rhizome, Poria, Angelica, Rhizoma Chuanxiong and Alisma. [0003] In the related art, the preparation method of Guishao Tiaojing Tablets is as follows: first distill Angelica and Chuanxiong to obtain volatile oil and medicinal residues; then combine the medicinal residues with other five-flavored medicinal materials for decoction, and then filter, concentrate, and decoct the obtained solution successively. Alcohol precipitation, recovery of ethanol, drying, crushing, and granulation to obtain drug granules; finally, the above-mentioned volatile oil is directly sprayed ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/884A61K47/48A61P15/00
Inventor 李军雷永李迎春陈海刚龚小兵
Owner 华润三九(郴州)制药有限公司
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