Composite playing auxiliary protection role in chemical and alcoholic liver injury, preparation method of composite and application of composite in health-care food

A technology for alcohol-induced liver injury and protective effects, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, applications, etc., can solve the problems of simple milk thistle flavonoids Toxic and side effects and other problems, to achieve significant effects of liver protection, overcome bad taste of drugs, and improve bioavailability

Inactive Publication Date: 2014-03-12
浙江康乐药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Invention patents have been published for a long time, but so far there is no corresponding product approved by the State Food and Drug Administration
The reason mainly has the limitations in the following aspects: 1. Long-term use of pure milk thistle flavono

Method used

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  • Composite playing auxiliary protection role in chemical and alcoholic liver injury, preparation method of composite and application of composite in health-care food
  • Composite playing auxiliary protection role in chemical and alcoholic liver injury, preparation method of composite and application of composite in health-care food
  • Composite playing auxiliary protection role in chemical and alcoholic liver injury, preparation method of composite and application of composite in health-care food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take the water and fly thistle seeds to remove the impurities, squeeze the oil, add 10 times ethanol, 60 o C return to extract, 2 hours each time, 2 times for extraction.Merge twice extract, condensed and dried at 60 ° C, that is, the water scoring extract is obtained.

[0021] Take the water with water, add 1.3 times the amount of lecithin, add 10 times the amount of 85%ethanol, heated back to dissolved, and recover the solvent to thick paste.The thick ointment composite is dry in the vacuum dryer, crushed and over 60 mesh sieves, that is, the pseudo-thistle extract-lecithin complex.

[0022] Take the puerassing medicinal materials to mix, crush, add 7 to 8 times 70%ethanol, extract the return, 1.5 to 2 hours each time, and extract twice.Merge twice extract, condensed and dry at 60 ° C, is to get Pueraria extract.

[0023] prescription:

[0024]

[0025] Method: According to the above-mentioned preparation prescription, the main water pistol extracts-lecithin complexes a...

Embodiment 2

[0027] Health foods that have auxiliary effects on chemical and alcoholic liver injuries, with thistle extracts-lecithin complexes, Pueraria extract, pre-glue starch, microcrystalline cellulose, carboxymethyl starch sodium, lipidic acid, stearic acidMagnesium composition, its weight percentage is water-flying thistle extract-25%of lecithin complexes, 20%of Pueraria extract, 22%pre-collapsed starch, 27%of microcrystalline cellulose, 4%of sodium carboxyne starch, hard fat fatMagamate 2%.The preparation method is the same as Example 1.

Embodiment 3

[0029] Health foods that have auxiliary effects on chemical and alcoholic liver injuries, with thistle extracts-lecithin complexes, Pueraria extract, pre-glue starch, microcrystalline cellulose, carboxymethyl starch sodium, lipidic acid, stearic acidMagnesium composition, its weight percentage is 22%of the lecithin complex, 22%of Pueraria extract, 25%pre-collagen starch, 25%of microcrystalline cellulose, 4%of sodium carboxyne starch, hard fat fatMagamate 2%.The preparation method is the same as Example 1.

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Abstract

The invention provides a composite which has high bioavailability, is suitable for being applied for a long time and plays an auxiliary protection role in chemical and alcoholic liver injury, a preparation method of the composite and application of the composite in health-care food. The composite comprises the following components in percentage by weight: 5%-45% of silybum marianum extractives-lecithin compounds, 5%-45% of radix puerariae extractives, 10%-50% of pregelatinized starch, 10%-50% of microcrystalline cellulose, 1%-10% of sodium carboxymethyl starch and 1%-5% of magnesium stearate. The production process provided by the invention is an environment-firendly advanced process and is less in environment pollution and high in application value; the obtained product is obviously enhanced in bioavailability, outstanding in liver protection effect, reduced in toxicity and suitable for being applied for a long time.

Description

Technical field [0001] The present invention involves a composition and preparation method of chemical and alcoholic liver damage and its application in health foods. Background technique [0002] ALD in my country has become a problem that cannot be ignored due to alcohol.Investigation and research shows that 32%to 45%of liver cancer (HCC) is caused by alcohol.ALD is one of the most important causes of liver disease in the world, and the most common cause of liver transplantation in Europe and the United States.With the rapid development of my country's economy, the improvement of people's living standards, the per capita alcohol consumption is significantly increased, and the prevalence of ALD is also increasing. At present, it has become the second largest cause of liver diseases second only to viral hepatitis.Survey survey data of alcoholic liver disease epidemiography in Zhejiang Province shows that the prevalence of plenty of alcoholic hepatitis in adult groups is 4.3%to 6....

Claims

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Application Information

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IPC IPC(8): A61K36/488A61K47/24A61P1/16A23L1/29A23L33/00
Inventor 陈长春余泳华张随楷郑启敏
Owner 浙江康乐药业股份有限公司
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