Preparation process and quality detection method of polysaccharide-iron complex

A quality detection method and complex technology, which are applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems of unsatisfactory production yield and the like

Active Publication Date: 2014-03-19
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The currently disclosed preparation process for the production of polysaccharide iron is not ideal for the improvement of production yield, so it is necessary to study and improve the process of polysaccharide iron complex

Method used

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  • Preparation process and quality detection method of polysaccharide-iron complex
  • Preparation process and quality detection method of polysaccharide-iron complex
  • Preparation process and quality detection method of polysaccharide-iron complex

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0059] Experimental example 1 The present invention polysaccharide iron complex preparation method operation process and technological condition experiment

[0060] 1. Ingredients:

[0061] Planned output: 33kg;

[0062] 1) Raw material A: ferric chloride solution (32%)

[0063] Weigh 93 kg of ferric chloride into a dissolving tank, add 194 kg of purified water, dissolve, and set aside.

[0064] 2) Raw material B: sodium hydroxide solution (15%)

[0065] Weigh 57kg of sodium hydroxide (solid alkali) into a dissolution kettle, add 310kg of purified water, dissolve, and set aside.

[0066] 3) Raw material C: syrup (solid content 25%)

[0067] Weigh 97.75 kg of syrup (50% solid content) into a dissolving kettle, add 97.75 kg of purified water, dissolve, and set aside.

[0068] 2. Reaction process

[0069] 1) Add the prepared syrup solution into a 1000L reaction tank, start stirring, stir for 10-15 minutes to make it evenly mixed, and pour tap water into it to cool;

[0070...

experiment example 2

[0090] Experimental Example 2 Comparison experiment of the anti-iron-deficiency anemia effect of the polysaccharide-iron complex obtained by the preparation method of the present invention

[0091] 1. Purpose of the experiment

[0092] The iron-deficiency anemia mouse animal model was reproduced by the method of low-iron feed feeding and blood loss model, to investigate the pharmacodynamic effect of the polysaccharide-iron complex prepared by the preparation method of the present invention.

[0093] 2. Materials and methods

[0094] 2.1. Materials

[0095] 2.1.1 Drugs:

[0096] The polysaccharide-iron complex administration group prepared by the preparation method described in Example 1 was three groups, which were high-dose group, middle-dose group and low-dose group. All provided by Natural Medicines Laboratory.

[0097] Refinon, produced by the American branch of Schwartz Pharmaceutical Group, Germany, product batch number 435260101

[0098] Each drug administration gr...

experiment example 3

[0124] Experimental Example 3 The control of the first alkali addition of the polysaccharide-iron complex of the present invention

[0125] In production research engineering, the yield of polysaccharide-iron complex is sometimes high, sometimes low, and sometimes even the final product cannot be obtained. After a lot of experimental research, it was unexpectedly found that the control of the first addition of lye is a key link. If the addition is too fast or excessive, the polysaccharide-iron complex cannot be formed later. After a lot of experiments, it was found that 220-250 parts by weight (preferably 190-210 parts by weight, 244 parts by weight, 225 parts by weight) of 10%-20% aqueous sodium hydroxide solution was added to the reaction tank within 60-90 minutes During the process, the reaction temperature is controlled at 15-25°C. After the feeding is completed, the stirring is continued until the reaction is completed within the above range, and finally the yield of the ...

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Abstract

The invention discloses a preparation process and a quality detection method of a polysaccharide-iron complex. The specific steps comprise: adding a syrup solution into a reaction tank, stirring, and cooling; adding a ferric chloride solution, stirring, and adding a sodium hydroxide solution to generate a red-brown gel; and adding a sodium hydroxide solution to obtain a precipitate, adding a precipitating agent to wash the precipitate twice, and drying to obtain the polysaccharide-iron complex. According to the present invention, the reaction steps are less, the reaction conditions are mild, reproducibility is good, the process conditions are reliable, and refrigeration equipment is not required; no waste gas is generated during the reaction, such that the problems that the pressure in the reaction tank is too high and the explosive hazard can be generated in the industrial production are reduced; and the polysaccharide-iron complex content determination method has characteristics of high accuracy, good precision, strong specificity, strong durability, meeting of linearity requirements, good accurate, high sensitivity, and simpleness.

Description

technical field [0001] The invention relates to a preparation process of a compound and a quality detection method thereof, in particular to a preparation process of a polysaccharide-iron compound and a quality detection method thereof. Background technique [0002] Anemia is a common disease, and its types can be roughly divided into iron deficiency anemia, hemolytic anemia, aplastic anemia and hemorrhagic anemia. The main causes of anemia are insufficient or impaired use of iron available to the body, and weakened bone marrow hematopoietic function, all of which can lead to decreased red blood cell production. [0003] Iron-deficiency anemia is one of the most common nutritional deficiency diseases in children in the world. It not only affects children's growth and development, but also affects immunity, brain function, and intellectual development. The prevalence of iron-deficiency anemia in children in my country is 57.6%. Mainly treated with iron. Iron-deficiency anemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H23/00C07H1/00G01N21/79G01N21/82A61P3/02A61P7/06
Inventor 王京端展莜林姜作玲张朋言
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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