Polypeptide valid target in Ropalidia fasciata insects and application thereof in preventing and treating cerebral thrombosis

A technology of effective parts and wasps, which is applied in the field of preparation of effective parts of polypeptides in insects of the genus Vespa, can solve the problems of low level of industrial production support and failure to form large-scale production capacity, and reduce cerebral edema and permeability , the effect of prolonging the breathing time
CN103641902AInactive Publication Date: 2014-03-19DALI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALI UNIV
Publication Date
2014-03-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a polypeptide valid target in Ropalidia fasciata insects and application thereof in preventing and treating cerebral thrombosis. The valid target is prepared by the following steps: dialyzing Ropalidia fasciata crude bee venom with a 30kDa dialysis membrane, and carrying out freeze-drying or vacuum concentration and drying on the dialysis solution. A series of pharmacodynamic experiments by people prove that the biotoxin polypeptide valid target and a transdermal absorption preparation thereof have obvious effects on preventing and treating cerebral thrombosis, restoring mobility of animals with cerebral palsy, preventing and treating platelet accumulation and relieving ischemic brain injury, and have better pharmacodynamic performance than Plavix, Xingnaojing injection and other first-tier medicines. The valid target is expected to be used for preparing innovative biochemical medicines for treating cardiovascular and cerebrovascular diseases and for preventing and treating ischemic cardiovascular and cerebrovascular diseases, such as myocardial infarction, cardiovascular thrombosis, cerebral thrombosis, cerebral infarction, acute / chronic cerebral apoplexy, and sequelae caused by cerebral infarction injury, including hemiplegia, hemidysesthesia, hemianopsia, facioplegia, paralysis lingualis, aphasia, pamplegia and the like.
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Description

technical field

[0001] The present invention relates to the technical field of medicine, in particular, the present invention relates to a preparation method and medical use of the effective part of the polypeptide in Vespa bellbellum insects. The effective part is obtained by dialyzing the crude bee venom of Vespa genus Bollina with a dialysis membrane of 25KDa, and the eluate is freeze-dried or concentrated and dried under reduced pressure. Through a series of pharmacological and pharmacodynamic experiments in animals, the inventors found that the effective part of the polypeptide has the effect of significantly preventing and treating cerebral thrombosis, restoring the activity ability of cerebral palsy animals, and reducing ischemic brain damage, and can be expected to be used in the preparation of anti-cardiac and cerebrovascular diseases. Vascular diseases include drugs, health care products, medical devices and daily chemicals for ischemic cerebrovascular disease and is...

Claims

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