Technological method of preparing vessels and networks quiet injection preparation

An injection preparation, the technology of Mailuoning, which is applied in the field of preparation of Mailuoning injection preparations, can solve problems such as no extraction, improper preparation of oral preparations, and increased dosage of medicinal materials, so as to prolong the bleeding time and coagulation time, and reduce cerebral edema state, the effect of prolonging breathing time

Active Publication Date: 2007-02-21
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN1078148A discloses the process of Mailuoning intravenous injection, which mainly adopts the process of water extraction, alcohol precipitation, and then extraction with ethyl acetate. Extract the fat-soluble components of the traditional Chinese medicinal flavor (such as achyrantherosterone), in addition, use water to extract and then alcohol precipitation, and remove the polysaccharide components that have medicinal effects in the traditional Chinese medicinal materials, (Mao Pingxia Huili, Yuan Xiurong, Ye Weicheng Huai Niu Experimental study on the anticoagulant effect of knee polysaccharides. Shi Zhen Guo Yi Guo Yao. 2000, 11 (12): 1075-1076); in addition, the extraction process uses ethyl acetate, because the solubility of saponins in ethyl acetate is small, so that The extraction rate of saponins is low or cannot be extracted at all. It is a pity to lose this component
Chinese patent CN1435250 discloses the preparation method of Mailuoning solid oral preparation for injection. It uses methanol and chloroform combined with ultrasonic extraction. Due to the low boiling point and high toxicity of methanol and chloroform, it is not suitable for the preparation of oral preparations and is not suitable for industrial production.
Moreover, the amount of Chinese herbal medicines in this patent is further expanded. The amount of crude drugs per 10ml of injections is equivalent to 200g; the equivalent amount of crude drugs per bag of granules even reaches 400g, which is a great waste of medicinal materials.

Method used

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  • Technological method of preparing vessels and networks quiet injection preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prescription: Achyranthes bidentata 3750 grams Scrophulariaceae 3750 grams Honeysuckle 3750 grams Dendrobium 3750 grams

[0028] Extraction and preparation:

[0029] Grind Achyranthes bidentata and Scrophulariaceae into the coarsest powder, take prescription amount of Achyranthes bidentata and Scrophulariae scrophulariae, add 6 times the amount of 70% ethanol or 8 times the amount of 60% ethanol to reflux and extract twice, the first time for 2 hours, the second time For the second 1 hour, combine the extracts, filter the medicinal residues for later use; the supernatant is decompressed to recover ethanol until it has no alcohol smell, then add appropriate amount of water to dilute (dilute to 1ml extract contains 1 gram of crude drug), and centrifuge at a high speed (20000 rpm / min) to precipitate, supernatant on D 101 Macroporous adsorption resin column, the volume on the column is 1ml resin to absorb 2ml extract, first wash with water equal to the volume of the colum...

Embodiment 2

[0037] 1. Prescription: Achyranthes bidentata 7500 grams Scrophulariaceae 7500 grams Honeysuckle 7500 grams Dendrobium 7500 grams The extraction method is the same as in Example 1.

[0038] Take Achyranthes bidentata, Scrophulariae extract A, honeysuckle extract, Achyranthes bidentata, Scrophulariaceae, Dendrobium polysaccharide extract, mix and grind, add 3000ml of water for injection, heat and stir to dissolve, adjust the pH value to about 5.5 with meglumine, and release it naturally Cold, refrigerated for 48 hours, filtered to obtain filtrate C; take Dendrobium extract A and pulverize, add 3 times the amount of propylene glycol, slightly heat to dissolve, add to filtrate C while stirring, make up the volume to 6000ml with water for injection, use Adjust the pH value of meglumine to 5.5~6.5, add 0.1% activated carbon, keep warm at 80°C for 15 minutes, filter out the activated carbon, sterilize and filter, fill into 15ml ampoules, 10ml per bottle, melt seal and sterilize , li...

Embodiment 1

[0061] Pharmacological embodiment 1, the influence of Mailuoning freeze-dried powder injection of the present invention on middle cerebral artery thrombosis model (MCAT) rats

[0062] experiment material

[0063] 1. Drugs and reagents

[0064] Test drug: Mailuoning freeze-dried powder injection of the present invention, provided by the laboratory of Beijing Ganluchun Technology Co., Ltd. Specifications: 7.5g / bottle (including crude drug content). Batch number: 20020529, prepared with normal saline before the test. The dosage for humans is 1-2 bottles a day.

[0065] Positive control drug: commercially available Mailuoning injection, produced by Nanjing Jinling Pharmaceutical Co., Ltd., batch number: 20020306, specification: 10ml / bottle (containing 100g of crude drug). Function clearing away heat and nourishing yin, promoting blood circulation and removing blood stasis. Clinical human dosage is 10-30ml / day.

[0066] Reagents and medicines: FeCl 3 ·6H 2 O(A.R.), product ...

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Abstract

A process for preparing Mailuoning injection features that the achyranthes root, scrophularia root, dendrobium and honeysuckle flower are individually or simultaneously extracted to increase the contents of their active components and their polyose components with medical function are maintained, resulting in high curative effect.

Description

Technical field [0001] The technology of the invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Mailuoning injection preparation. Background technique [0002] Mailuoning Injection is a traditional Chinese medicine compound injection developed on the basis of the famous medical prescription "Simiao Yong'an Decoction". The effect of kidney, nourishing yin and clearing away heat. Clinically, it is widely used in blood stasis syndrome and thrombotic occlusive vascular diseases in various departments, especially in the clinical application of treating cardiovascular and cerebrovascular diseases. etc. also have better curative effect. Toxicology studies have shown that Mailuoning injection has no effect on LD in mice. 50 It is 803.4g / kg, which is equivalent to 482 times of the lower limit and 241 times of the upper limit of the clinical dosage of a 60kg person (Wang Qin. Mailuoning Injection Collection....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61K36/808A61K36/35A61K36/21A61K9/08A61P9/10
Inventor 张正生
Owner TIANJIN TASLY PHARMA CO LTD
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