Composite degradable antibacterial artificial cerebral dura mater and preparation method thereof
An artificial dura mater and composite technology, applied in medical science, prosthesis, etc., can solve problems such as incomplete satisfaction, and achieve the effect of good film quality, good biological characteristics, and good compatibility
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[0020] Example 1: Taking bovine tendon as one of the decellularized membranous biologically derived materials as an example to illustrate its specific composite degradable antibacterial artificial dura mater preparation method, the other decellularized membranous biologically derived materials are the same as in Example 1 : Include the following steps:
[0021]1) Preparation of sponge-like collagen biofilm scaffolds; prepared by freeze-drying collagen membranes, with a porous and loose structure, and good penetration and water absorption capabilities. Bovine tendon, one of the decellularized membrane-like bio-derived materials, was placed at 75 % ethanol solution and peracetic acid for 2 hours, rinsed repeatedly with phosphate buffer for 3 times; soaked in sodium hydroxide solution for 2 hours, then rinsed with phosphate buffer until pH7.4; Freeze in low-temperature liquid nitrogen at -80°C for 24 hours, freeze-dry in a vacuum freeze dryer for 24 hours, and pulverize with a li...
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