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Method for measuring Young modulus of single cell based on micro-fluidic technology

A microfluidic technology and Young's modulus technology, which is applied in the field of measuring the Young's modulus of a single cell based on the microfluidic technology, can solve the problem that the quantitative measurement of the Young's modulus of the cell cannot be realized, and achieves low cost and can be transplanted. high sex effect

Active Publication Date: 2014-03-26
INST OF ELECTRONICS CHINESE ACAD OF SCI
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Problems solved by technology

[0006] However, the existing microfluidic chips for high-throughput characterization of cell mechanical properties can only characterize some mechanical property parameters that depend on cell size, such as degree of deformation, etc., and cannot quantify the intrinsic mechanical property parameters of cells, that is, the Young's modulus of cells. Measurement

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  • Method for measuring Young modulus of single cell based on micro-fluidic technology
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[0027] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be described in further detail below in conjunction with specific embodiments and with reference to the accompanying drawings. It should be noted that, in the drawings or descriptions of the specification, similar or identical parts all use the same figure numbers. Implementations not shown or described in the accompanying drawings are forms known to those of ordinary skill in the art. Additionally, while illustrations of parameters including particular values ​​may be provided herein, it should be understood that the parameters need not be exactly equal to the corresponding values, but rather may approximate the corresponding values ​​within acceptable error margins or design constraints.

[0028] In the present invention, the cell is equivalent to an isotropic viscoelastic body, and based on the relationship between the displacement of the front ...

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Abstract

The invention provides a method for measuring Young modulus of single cell based on micro-fluidic technology. According to the method, a to-be-measured cell is equivalent to an isotropous viscoelastic body, with an equivalent mechanical model of the to-be-measured cell of entering and running through a compression channel, based on a relation of a displacement of the front end of the to-be-measured of instantly entering the compression channel, the size of the cell, the Yong modules, the intensity of pressure, and the geometric parameters of the compression channel, the measurement for the Young modulus of the to-be-measured cell is realized.

Description

technical field [0001] The invention relates to the technical field of biological information detection, in particular to a method for measuring the Young's modulus of a single cell based on microfluidic technology. Background technique [0002] As the basic unit of life activities, cells contain various biomolecules that interact with each other to form a busy and orderly system. As an important functional unit of cells, the cytoskeleton participates in important physiological functions such as cell proliferation, division and deformation, and is closely related to the state of cells. Preliminary studies have shown that tumor cells with different degrees of malignancy and stem cells with different degrees of differentiation have differences in cytoskeleton functions, which are manifested in differences in cell mechanical characteristic parameters, namely Young's modulus. Therefore, the high-throughput acquisition of Young's modulus of single cells can provide a reliable me...

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Application Information

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IPC IPC(8): G01N15/10
Inventor 陈健罗亚娜龙荣赵阳陈德勇王军波
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI
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