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A bone graft material embedded in bone material gel in prf

A bone material and bone grafting technology, applied in medical science, prosthesis, etc., can solve the problems of complicated operation, high risk of using biological agents, fast degradation, etc., and achieve the effect of simple operation, strong tension, and slow degradation

Active Publication Date: 2015-12-09
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a bone graft material embedded in bone material gel in the PRF in order to solve the defects of high risk of use of biological agents, rapid degradation, and complicated operation in the existing bone material technology.

Method used

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  • A bone graft material embedded in bone material gel in prf
  • A bone graft material embedded in bone material gel in prf
  • A bone graft material embedded in bone material gel in prf

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 4ml of non-anticoagulated whole blood was collected in an empty Vacuette tube. Immediately put the blood sample into the centrifuge (AnkeTDL-80-2D China), adjust the centrifugal force of 130g, and centrifuge for 4 minutes; take out the layered blood sample, the upper layer is turbid light yellow liquid, the lower layer is red blood cell layer, and the middle layer is buffy coat Very unclear; suck all the turbid light yellow liquid in the upper layer into the ceramic double dish; draw 500μl into the other hole of the double dish, pour the prepared 50mg Bio-Oss bone meal particles with a diameter of 0.25mm, so that the yellow liquid naturally penetrates into the bone meal particles ; Stand at room temperature. After 30 minutes, use tweezers to pick up the yellow and white PRF-bone powder particle gel mass, which is the target product. The PRF-bone meal granule gel that is pinched into agglomeration with tweezers has certain elasticity and toughness, and the bone meal gra...

Embodiment 2

[0031] 4ml of non-anticoagulated whole blood was collected in an empty Vacuette tube. Immediately put the blood sample into the centrifuge (AnkeTDL-80-2D China), adjust the centrifugal force of 270g, and centrifuge for 3 minutes; take out the layered blood sample, the upper layer is a turbid light yellow liquid, the lower layer is a red blood cell layer, and the middle is very thin Yarn film layer; suck all the light yellow liquid in the upper layer into the ceramic double dish; absorb 500μl and add it into the other hole of the double dish, pour the prepared 50mg Bio-Oss bone meal particles with a diameter of 0.25mm, so that the yellow liquid naturally penetrates into the bone meal particles; Let stand at room temperature. After 30 minutes, use tweezers to pick up the yellow and white PRF-bone powder particle gel mass, which is the target product. The PRF-bone meal granule gel that is pinched into a ball with tweezers has a certain degree of elasticity and toughness, and the b...

Embodiment 3

[0033] 4ml of non-anticoagulated whole blood was collected in an empty Vacuette tube. Immediately put the blood sample into the centrifuge (AnkeTDL-80-2D China), adjust the centrifugal force of 390g, and centrifuge for 2 minutes; take out the layered blood sample, the upper layer is light yellow liquid, the lower layer is red blood cell layer, and the middle layer is buffy coat; Suck all the light yellow liquid above the buffy coat into the ceramic double disc; draw 500 μl into the other hole of the double disc, pour the prepared 50 mg Bio-Oss bone powder particles with a diameter of 0.25 mm into the yellow liquid, so that the yellow liquid naturally penetrates into the bone powder particles Middle; stand at room temperature for 35 minutes, pick up the yellow and white PRF-bone powder particle gel mass with tweezers, which is the target product. The PRF-bone meal granule gel that is pinched into a ball with tweezers has a certain degree of elasticity and toughness, and the bon...

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Abstract

The invention relates to a bone grafting material by embedding a bone material gel in PRF (platelet-rich fibrin), and belongs to the field of bone grafting operation. The bone grafting material is prepared by the following steps: performing centrifugal operation on a non-anticoagulant blood sample by a centrifugal machine at a centrifugal force of 130-460g; mixing all upper yellow liquid and the bone material, and standing for 30-40 minutes at room temperature to obtain the bone grafting material. The bone grafting material is a whole clot, PRF in the product reacts with the bone material, leukocyte and platelet in PRF are uniformly distributed, and PRF is widely and comprehensively contacted with the bone material. The bone grafting material is high in plasticization, and is a perfect bone grafting material with a complete frame supporting structure.

Description

technical field [0001] The invention relates to a bone graft material embedded with bone material gel in PRF, belonging to the field of materials for bone graft operations. Background technique [0002] Healing after bone grafting needs to go through 3 main stages, hematoma organization stage (2 weeks), this stage is mainly platelet aggregation and activation, granulocyte and macrophage migration; primitive callus formation stage (3-8 weeks) , is the proliferation, differentiation and reproduction period of mesenchymal cells; the reconstruction of various tissue cells in the plastic period (8-12 weeks). The platelet aggregation in the hematoma organization phase starts the coagulation reaction, and there are two ways to complete the whole process, one is repair and the other is regeneration. The repair process is that when the tissue damage exceeds a certain limit, the proliferation and differentiation of mesenchymal cells cannot meet the needs of tissue regeneration. At th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/54
Inventor 陈智滨栾庆先刘凯宁
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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