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Vitamin K2 compound for preventing and treating arthritis

An osteoarthritis and vitamin technology, applied in the fields of food science, bone disease, drug combination, etc., can solve the problems of unapplied prevention and treatment of osteoarthritis, antagonism of osteoarthritis and osteoporosis, etc., and achieves good administration safety. The effect of relieving or inhibiting osteoarthritis, protecting cartilage and bone matrix

Inactive Publication Date: 2014-04-09
昆明云大医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, vitamin K2 alone or in combination with vitamin D has been widely used in the prevention and treatment of osteoporosis, but vitamin K2 and / or vitamin D have not been used in the prevention and treatment of osteoarthritis, because most people in the industry It is still believed that there is a range of antagonism between osteoarthritis and osteoporosis, and the chance of co-occurrence in the same patient is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 In a clean room, operate in the dark, add 0.05g of vitamin K2 (35) and 0.005g of vitamin D3 to 499.945g of walnut oil, heat and stir at 40°C to dissolve, then add 500g of glucosamine hydrochloride under stirring , mixed evenly, and made into 1000g mixture to make soft capsules. Each capsule contains 0.5g, and each capsule contains 25ug of vitamin K2 (35), 2.5ug of vitamin D3, and 250mg of glucosamine hydrochloride.

Embodiment 2

[0027] Example 2 In a clean room, operate in the dark, add 0.25g of vitamin K2 (20) and 0.01g of vitamin D2 to 249.740g of soybean oil, heat and stir at 40°C to dissolve, then add 750g of glucosamine sulfate under stirring , mixed evenly, and made into 1000g mixture to make soft capsules. Each capsule contains 0.5g, and each capsule contains 125ug of vitamin K2 (20), 5ug of vitamin D2, and 375mg of glucosamine sulfate.

Embodiment 3

[0028] Example 3 In a clean room, operate in the dark, add 0.10g of vitamin K2 (45) and 0.01g of vitamin D3 to 399.890g of sunflower oil, heat and stir at 40°C to dissolve, then add 600g of amino sulfate under stirring Glucose, mix homogeneously, be made into 1000g mixture and make soft capsule. Each capsule contains 0.5g, and each capsule contains 50ug of vitamin K2 (45), 5ug of vitamin D3, and 300mg of glucosamine sulfate.

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PUM

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Abstract

The invention provides a vitamin K2 compound for preventing and treating arthritis, and belongs to the field of medicine or health-care food formulae. Per 1000g of the compound comprises 0.05-0.25g of vitamin K2, 0.005-0.01g of vitamin D, 500-750g of glucosamine and 499.945-249.740g of solid or liquid matrix. The compound which is mechanically stirred and uniformly mixed under a normal temperature or heating condition is prepared to soft capsules, hard capsules or troches. The medicine or health-care food formed by the formula has remarkable preventing and treating effects on common osteoarthritis of the middle aged or the aged people, especially postmenopausal women.

Description

technical field [0001] The present invention relates to medicine or health food formula. Specifically, it relates to a compound useful for the prevention and treatment of osteoarthritis. Background technique [0002] Osteoarthritis is the most common joint disease affecting human health and is second only to cardiovascular disease in causing long-term disability in people over the age of 50. Osteoarthritis is a systemic metabolic bone disease. There is abnormal bone mineral metabolism in the subchondral bone. The mechanism of osteoarthritis is very complicated and there is no clear conclusion so far. However, osteoarthritis is the same as osteoporosis. Bone diseases induced by abnormal mineral metabolism, the occurrence of osteoarthritis involves many mechanisms, including the effects of growth factors and cytokines on chondrocytes and the synthesis of cartilage matrix, enzymatic degradation of bone matrix, bone repair, etc. . [0003] The bone morphology of osteoarthriti...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A23L1/29A61P19/02A61K31/122A61K31/592A61K31/593A23L33/00
Inventor 雷泽朱洪友张爱华方瑞斌付正启木晓云温晓江
Owner 昆明云大医药开发有限公司
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